Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BBQ

Model for extended volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A Arf6 Q67L fusion protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000281	biological_process	mitotic cytokinesis
A	0001726	cellular_component	ruffle
A	0001889	biological_process	liver development
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0005938	cellular_component	cell cortex
A	0006886	biological_process	intracellular protein transport
A	0006904	biological_process	vesicle docking involved in exocytosis
A	0007155	biological_process	cell adhesion
A	0007399	biological_process	nervous system development
A	0010008	cellular_component	endosome membrane
A	0010975	biological_process	regulation of neuron projection development
A	0010976	biological_process	positive regulation of neuron projection development
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0030139	cellular_component	endocytic vesicle
A	0030154	biological_process	cell differentiation
A	0030496	cellular_component	midbody
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0030866	biological_process	cortical actin cytoskeleton organization
A	0031527	cellular_component	filopodium membrane
A	0031901	cellular_component	early endosome membrane
A	0031996	molecular_function	thioesterase binding
A	0032012	biological_process	regulation of ARF protein signal transduction
A	0032154	cellular_component	cleavage furrow
A	0032456	biological_process	endocytic recycling
A	0034394	biological_process	protein localization to cell surface
A	0035020	biological_process	regulation of Rac protein signal transduction
A	0035591	molecular_function	signaling adaptor activity
A	0036010	biological_process	protein localization to endosome
A	0042995	cellular_component	cell projection
A	0048261	biological_process	negative regulation of receptor-mediated endocytosis
A	0048488	biological_process	synaptic vesicle endocytosis
A	0050714	biological_process	positive regulation of protein secretion
A	0051301	biological_process	cell division
A	0051489	biological_process	regulation of filopodium assembly
A	0051549	biological_process	positive regulation of keratinocyte migration
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0060998	biological_process	regulation of dendritic spine development
A	0070062	cellular_component	extracellular exosome
A	0071726	biological_process	cellular response to diacyl bacterial lipopeptide
A	0072659	biological_process	protein localization to plasma membrane
A	0090162	biological_process	establishment of epithelial cell polarity
A	0090543	cellular_component	Flemming body
A	0097178	biological_process	ruffle assembly
A	0097284	biological_process	hepatocyte apoptotic process
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099562	biological_process	maintenance of postsynaptic density structure
A	0120183	biological_process	positive regulation of focal adhesion disassembly
A	1902217	biological_process	erythrocyte apoptotic process
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1903438	biological_process	positive regulation of mitotic cytokinetic process
A	1905345	biological_process	protein localization to cleavage furrow
A	1905606	biological_process	regulation of presynapse assembly
A	1990090	biological_process	cellular response to nerve growth factor stimulus
A	2000009	biological_process	negative regulation of protein localization to cell surface
A	2000171	biological_process	negative regulation of dendrite development

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue GTP A 601

Chain	Residue
A	ASP420
A	GLY463
A	GLY464
A	ASN520
A	LYS521
A	ASP523
A	LEU524
A	CYS553
A	ALA554
A	MG602
A	ALA421
A	ALA422
A	GLY423
A	LYS424
A	THR425
A	THR426
A	THR439
A	THR442

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 602

Chain	Residue
A	THR425
A	THR442
A	GTP601

site_id	AC3
Number of Residues	13
Details	binding site for residue 4IP A 603

Chain	Residue
A	LYS273
A	GLY275
A	GLY276
A	ARG277
A	VAL278
A	THR280
A	LYS282
A	ARG284
A	TYR295
A	ARG305
A	LYS343
A	ASN354
A	HIS355

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	129
Details	Domain: {"description":"SEC7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	116
Details	Domain: {"description":"PH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"C-terminal autoinhibitory region"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10983984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15359279","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16099990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19644450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21170023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22939626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23940353","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7589240","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Lipidation: {"description":"N6-myristoyl lysine","evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)