Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BBM

Mechanisms of Opening and Closing of the Bacterial Replicative Helicase: The DnaB Helicase and Lambda P Helicase Loader Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0010212	biological_process	response to ionizing radiation
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030894	cellular_component	replisome
A	0031297	biological_process	replication fork processing
A	0033202	cellular_component	DNA helicase complex
A	0042802	molecular_function	identical protein binding
A	0043139	molecular_function	5'-3' DNA helicase activity
A	1990077	cellular_component	primosome complex
A	1990100	cellular_component	DnaB-DnaC complex
A	1990156	cellular_component	DnaB-DnaG complex
A	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
A	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
A	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006269	biological_process	DNA replication, synthesis of primer
B	0006270	biological_process	DNA replication initiation
B	0010212	biological_process	response to ionizing radiation
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030894	cellular_component	replisome
B	0031297	biological_process	replication fork processing
B	0033202	cellular_component	DNA helicase complex
B	0042802	molecular_function	identical protein binding
B	0043139	molecular_function	5'-3' DNA helicase activity
B	1990077	cellular_component	primosome complex
B	1990100	cellular_component	DnaB-DnaC complex
B	1990156	cellular_component	DnaB-DnaG complex
B	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
B	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
B	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006269	biological_process	DNA replication, synthesis of primer
C	0006270	biological_process	DNA replication initiation
C	0010212	biological_process	response to ionizing radiation
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030894	cellular_component	replisome
C	0031297	biological_process	replication fork processing
C	0033202	cellular_component	DNA helicase complex
C	0042802	molecular_function	identical protein binding
C	0043139	molecular_function	5'-3' DNA helicase activity
C	1990077	cellular_component	primosome complex
C	1990100	cellular_component	DnaB-DnaC complex
C	1990156	cellular_component	DnaB-DnaG complex
C	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
C	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
C	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006269	biological_process	DNA replication, synthesis of primer
D	0006270	biological_process	DNA replication initiation
D	0010212	biological_process	response to ionizing radiation
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030894	cellular_component	replisome
D	0031297	biological_process	replication fork processing
D	0033202	cellular_component	DNA helicase complex
D	0042802	molecular_function	identical protein binding
D	0043139	molecular_function	5'-3' DNA helicase activity
D	1990077	cellular_component	primosome complex
D	1990100	cellular_component	DnaB-DnaC complex
D	1990156	cellular_component	DnaB-DnaG complex
D	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
D	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
D	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0010212	biological_process	response to ionizing radiation
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030894	cellular_component	replisome
E	0031297	biological_process	replication fork processing
E	0033202	cellular_component	DNA helicase complex
E	0042802	molecular_function	identical protein binding
E	0043139	molecular_function	5'-3' DNA helicase activity
E	1990077	cellular_component	primosome complex
E	1990100	cellular_component	DnaB-DnaC complex
E	1990156	cellular_component	DnaB-DnaG complex
E	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
E	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
E	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006269	biological_process	DNA replication, synthesis of primer
F	0006270	biological_process	DNA replication initiation
F	0010212	biological_process	response to ionizing radiation
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030894	cellular_component	replisome
F	0031297	biological_process	replication fork processing
F	0033202	cellular_component	DNA helicase complex
F	0042802	molecular_function	identical protein binding
F	0043139	molecular_function	5'-3' DNA helicase activity
F	1990077	cellular_component	primosome complex
F	1990100	cellular_component	DnaB-DnaC complex
F	1990156	cellular_component	DnaB-DnaG complex
F	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
F	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
F	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
V	0006270	biological_process	DNA replication initiation
W	0006270	biological_process	DNA replication initiation
X	0006270	biological_process	DNA replication initiation
Y	0006270	biological_process	DNA replication initiation
Z	0006270	biological_process	DNA replication initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue ADP A 500

Chain	Residue
A	SER234
F	ASN443
A	GLY236
A	LYS237
A	THR238
A	THR239
A	ARG271
A	GLN281
A	GLY455
F	ARG442

site_id	AC2
Number of Residues	14
Details	binding site for residue ADP C 500

Chain	Residue
B	ARG442
B	ASN443
B	GLY444
C	ARG232
C	PRO233
C	SER234
C	MET235
C	GLY236
C	LYS237
C	THR238
C	THR239
C	GLU262
C	ARG271
C	ARG420

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP E 501

Chain	Residue
D	ARG442
D	GLY444
E	SER234
E	GLY236
E	LYS237
E	THR238
E	THR239
E	GLU262
E	MET263
E	ARG271
E	ASP280
E	GLN281
E	GLY455

site_id	AC4
Number of Residues	10
Details	binding site for residue ADP E 502

Chain	Residue
E	ARG442
F	SER234
F	MET235
F	GLY236
F	LYS237
F	THR238
F	THR239
F	ARG271
F	GLN281
F	GLY455

site_id	AC5
Number of Residues	6
Details	binding site for residue ADP W 500

Chain	Residue
C	ARG442
D	SER234
D	GLY236
D	LYS237
D	THR238
D	ARG271

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30582519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1068
Details	Domain: {"description":"SF4 helicase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00596","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)