6BBA

Crystal structure of human mitochondrial ClpP complex with acyldepsipeptide ADEP-28

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TwcVGqAASMGS

Chain	Residue	Details
A	THR188-SER199

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site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RhslPnsrIMIHQP

Chain	Residue	Details
A	ARG210-PRO223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:11923310

Chain	Residue	Details
A	SER196
B	SER196
C	SER196
D	SER196
E	SER196
F	SER196
G	SER196

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site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS221
B	HIS221
C	HIS221
D	HIS221
E	HIS221
F	HIS221
G	HIS221

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site_id	SWS_FT_FI3
Number of Residues	7
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O88696

Chain	Residue	Details
A	LYS243
B	LYS243
C	LYS243
D	LYS243
E	LYS243
F	LYS243
G	LYS243

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site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS254
B	LYS254
C	LYS254
D	LYS254
E	LYS254
F	LYS254
G	LYS254

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