6BAW

Structure of GRP94 with a selective resorcinylic inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
C	0005524	molecular_function	ATP binding
C	0006457	biological_process	protein folding
C	0016887	molecular_function	ATP hydrolysis activity
C	0051082	molecular_function	unfolded protein binding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
D	0005524	molecular_function	ATP binding
D	0006457	biological_process	protein folding
D	0016887	molecular_function	ATP hydrolysis activity
D	0051082	molecular_function	unfolded protein binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue D57 B 401

Chain	Residue
B	ALA111
B	HOH508
B	HOH516
B	ASP149
B	GLY153
B	MET154
B	ASN162
B	LEU163
B	PHE195
B	THR245
B	ILE247

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO B 402

Chain	Residue
B	ARG156
B	ASP218
B	HIS221
B	PO4405

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO B 403

Chain	Residue
B	GLU224
B	ASP226
B	GLU229
B	SER231
C	ARG156

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 B 404

Chain	Residue
B	LYS114
B	ILE118
B	GLU158
B	HIS215
B	HOH518

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PO4 B 405

Chain	Residue
B	ARG156
B	ALA234
B	EDO402
C	LYS208
C	GLU224

---

site_id	AC6
Number of Residues	13
Details	binding site for residue D57 A 401

Chain	Residue
A	ASN107
A	ALA111
A	ASP149
A	GLY153
A	MET154
A	ASN162
A	LEU163
A	PHE195
A	TRP223
A	THR245
A	ILE247
A	HOH505
A	HOH507

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 402

Chain	Residue
A	ARG156
A	ASP218
A	THR219
A	HIS221
A	PO4407

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 403

Chain	Residue
A	SER169
A	GLU224
A	ASP226
A	PHE230
A	SER231
D	ARG156

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 404

Chain	Residue
A	LYS137
A	THR148
A	EDO405

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 405

Chain	Residue
A	THR212
A	ARG237
A	EDO404

---

site_id	AD2
Number of Residues	3
Details	binding site for residue PO4 A 406

Chain	Residue
A	LYS114
A	GLU158
A	HIS215

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 A 407

Chain	Residue
A	ILE233
A	ALA234
A	EDO402
D	LYS208
D	GLU224

---

site_id	AD4
Number of Residues	11
Details	binding site for residue D57 C 401

Chain	Residue
C	ASN107
C	ALA111
C	ASP149
C	VAL152
C	GLY153
C	MET154
C	ASN162
C	PHE195
C	THR245
C	ILE247
C	HOH502

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO C 402

Chain	Residue
C	ASP207
C	LYS252
C	GLU253
C	GLU254

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO C 403

Chain	Residue
C	LYS137
C	ASP139
C	HIS146

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO C 404

Chain	Residue
C	THR212
C	ARG237
C	THR246

---

site_id	AD8
Number of Residues	4
Details	binding site for residue PO4 C 405

Chain	Residue
B	LYS208
C	ARG156
C	ASP218
C	HIS221

---

site_id	AD9
Number of Residues	9
Details	binding site for residue D57 D 401

Chain	Residue
D	PHE195
D	THR245
D	ILE247
D	ASN107
D	ALA111
D	ASP149
D	GLY153
D	MET154
D	ASN162

---

site_id	AE1
Number of Residues	3
Details	binding site for residue EDO D 402

Chain	Residue
D	LYS137
D	ASP139
D	HIS146

---

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO D 403

Chain	Residue
D	THR212
D	ARG237
D	THR246

---

site_id	AE3
Number of Residues	4
Details	binding site for residue PO4 D 404

Chain	Residue
D	ARG156
D	ASP218
D	THR219
D	HIS221

---

site_id	AE4
Number of Residues	4
Details	binding site for residue PO4 D 405

Chain	Residue
C	LYS265
C	GLU334
D	LYS265
D	GLU334

---

Functional Information from PROSITE/UniProt

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YkNKEIFLRE

Chain	Residue	Details
B	TYR94-GLU103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"UniProtKB","id":"P14625","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q66HD0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---