Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BAL

2.1 Angstrom Resolution Crystal Structure of Malate Dehydrogenase from Haemophilus influenzae in Complex with L-Malate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006099	biological_process	tricarboxylic acid cycle
A	0006108	biological_process	malate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016615	molecular_function	malate dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0006099	biological_process	tricarboxylic acid cycle
B	0006108	biological_process	malate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016615	molecular_function	malate dehydrogenase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
C	0003824	molecular_function	catalytic activity
C	0005737	cellular_component	cytoplasm
C	0006099	biological_process	tricarboxylic acid cycle
C	0006108	biological_process	malate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016615	molecular_function	malate dehydrogenase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
D	0003824	molecular_function	catalytic activity
D	0005737	cellular_component	cytoplasm
D	0006099	biological_process	tricarboxylic acid cycle
D	0006108	biological_process	malate metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016615	molecular_function	malate dehydrogenase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
E	0003824	molecular_function	catalytic activity
E	0005737	cellular_component	cytoplasm
E	0006099	biological_process	tricarboxylic acid cycle
E	0006108	biological_process	malate metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016615	molecular_function	malate dehydrogenase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
E	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
F	0003824	molecular_function	catalytic activity
F	0005737	cellular_component	cytoplasm
F	0006099	biological_process	tricarboxylic acid cycle
F	0006108	biological_process	malate metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016615	molecular_function	malate dehydrogenase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
F	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
G	0003824	molecular_function	catalytic activity
G	0005737	cellular_component	cytoplasm
G	0006099	biological_process	tricarboxylic acid cycle
G	0006108	biological_process	malate metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016615	molecular_function	malate dehydrogenase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
G	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
H	0003824	molecular_function	catalytic activity
H	0005737	cellular_component	cytoplasm
H	0006099	biological_process	tricarboxylic acid cycle
H	0006108	biological_process	malate metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016615	molecular_function	malate dehydrogenase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
H	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue LMR A 401

Chain	Residue
A	ARG81
A	ARG87
A	ASN119
A	ARG153
A	HIS177
A	SER222
A	ALA223
A	HOH563

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
B	GLN23
A	GLN23

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 403

Chain	Residue
A	GLN229
A	ARG233
A	HOH631

site_id	AC4
Number of Residues	5
Details	binding site for residue CL B 401

Chain	Residue
B	ARG87
B	PRO120
B	VAL121
B	ASN122
B	SER178

site_id	AC5
Number of Residues	2
Details	binding site for residue CL B 402

Chain	Residue
B	GLN229
B	ARG233

site_id	AC6
Number of Residues	4
Details	binding site for residue CL C 401

Chain	Residue
C	VAL121
C	ASN122
C	SER178
C	HOH632

site_id	AC7
Number of Residues	2
Details	binding site for residue CL C 402

Chain	Residue
C	GLN23
D	GLN23

site_id	AC8
Number of Residues	4
Details	binding site for residue CL C 403

Chain	Residue
C	GLN229
C	ARG233
C	HOH505
D	HOH674

site_id	AC9
Number of Residues	5
Details	binding site for residue CL D 401

Chain	Residue
D	PRO120
D	VAL121
D	ASN122
D	HIS177
D	HOH645

site_id	AD1
Number of Residues	2
Details	binding site for residue CL D 402

Chain	Residue
D	GLN229
D	ARG233

site_id	AD2
Number of Residues	5
Details	binding site for residue CL E 401

Chain	Residue
E	PRO120
E	VAL121
E	ASN122
E	SER178
E	HOH577

site_id	AD3
Number of Residues	3
Details	binding site for residue CL E 402

Chain	Residue
E	GLN23
E	HOH654
F	GLN23

site_id	AD4
Number of Residues	3
Details	binding site for residue CL E 403

Chain	Residue
E	GLN229
E	ARG233
F	HOH613

site_id	AD5
Number of Residues	2
Details	binding site for residue CL F 401

Chain	Residue
F	ARG87
F	ARG153

site_id	AD6
Number of Residues	2
Details	binding site for residue CL F 402

Chain	Residue
F	GLN229
F	ARG233

site_id	AD7
Number of Residues	3
Details	binding site for residue CL G 401

Chain	Residue
G	GLN23
G	HOH594
H	GLN23

site_id	AD8
Number of Residues	4
Details	binding site for residue CL G 402

Chain	Residue
G	GLN229
G	ARG233
G	HOH537
H	PRO50

site_id	AD9
Number of Residues	5
Details	binding site for residue CL H 401

Chain	Residue
H	ARG87
H	PRO120
H	VAL121
H	ASN122
H	SER178

Functional Information from PROSITE/UniProt

site_id	PS00068
Number of Residues	13
Details	MDH Malate dehydrogenase active site signature. VTTLDvlRSetfV

Chain	Residue	Details
A	VAL146-VAL158

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	HIS177
B	HIS177
C	HIS177
D	HIS177
E	HIS177
F	HIS177
G	HIS177
H	HIS177

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY7
B	GLY7
B	ASP34
B	ARG81
B	ARG87
B	ASN94
B	ILE117
B	ASN119
B	ARG153
B	MET227
C	GLY7
A	ASP34
C	ASP34
C	ARG81
C	ARG87
C	ASN94
C	ILE117
C	ASN119
C	ARG153
C	MET227
D	GLY7
D	ASP34
A	ARG81
D	ARG81
D	ARG87
D	ASN94
D	ILE117
D	ASN119
D	ARG153
D	MET227
E	GLY7
E	ASP34
E	ARG81
A	ARG87
E	ARG87
E	ASN94
E	ILE117
E	ASN119
E	ARG153
E	MET227
F	GLY7
F	ASP34
F	ARG81
F	ARG87
A	ASN94
F	ASN94
F	ILE117
F	ASN119
F	ARG153
F	MET227
G	GLY7
G	ASP34
G	ARG81
G	ARG87
G	ASN94
A	ILE117
G	ILE117
G	ASN119
G	ARG153
G	MET227
H	GLY7
H	ASP34
H	ARG81
H	ARG87
H	ASN94
H	ILE117
A	ASN119
H	ASN119
H	ARG153
H	MET227
A	ARG153
A	MET227

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)