Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6B9T

Crystal structure of MPnS with substrate 2-hydroxyethylphosphonate (2-HEP) and Fe(II) bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0032923	biological_process	organic phosphonate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0055114	biological_process	obsolete oxidation-reduction process
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008198	molecular_function	ferrous iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B	0032923	biological_process	organic phosphonate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0055114	biological_process	obsolete oxidation-reduction process
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008198	molecular_function	ferrous iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C	0032923	biological_process	organic phosphonate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0055114	biological_process	obsolete oxidation-reduction process
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008198	molecular_function	ferrous iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D	0032923	biological_process	organic phosphonate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0055114	biological_process	obsolete oxidation-reduction process
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008198	molecular_function	ferrous iron binding
E	0016491	molecular_function	oxidoreductase activity
E	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
E	0032923	biological_process	organic phosphonate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0055114	biological_process	obsolete oxidation-reduction process
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008198	molecular_function	ferrous iron binding
F	0016491	molecular_function	oxidoreductase activity
F	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
F	0032923	biological_process	organic phosphonate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
F	0055114	biological_process	obsolete oxidation-reduction process
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008198	molecular_function	ferrous iron binding
G	0016491	molecular_function	oxidoreductase activity
G	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
G	0032923	biological_process	organic phosphonate biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
G	0055114	biological_process	obsolete oxidation-reduction process
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008198	molecular_function	ferrous iron binding
H	0016491	molecular_function	oxidoreductase activity
H	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H	0032923	biological_process	organic phosphonate biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0051213	molecular_function	dioxygenase activity
H	0055114	biological_process	obsolete oxidation-reduction process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FE A 501

Chain	Residue
A	HIS148
A	GLN152
A	HIS190
A	2HE502
A	HOH601

site_id	AC2
Number of Residues	14
Details	binding site for residue 2HE A 502

Chain	Residue
A	ASN145
A	HIS148
A	GLN152
A	HIS190
A	PHE192
A	FE501
A	HOH601
A	HOH653
B	LYS28
B	TRP449
A	ARG102
A	TYR108
A	TYR110
A	ILE126

site_id	AC3
Number of Residues	6
Details	binding site for residue FE B 501

Chain	Residue
A	LYS28
B	HIS148
B	GLN152
B	HIS190
B	2HE503
B	HOH621

site_id	AC4
Number of Residues	4
Details	binding site for residue FE B 502

Chain	Residue
B	GLU159
B	HOH609
H	GLU159
H	HOH696

site_id	AC5
Number of Residues	13
Details	binding site for residue 2HE B 503

Chain	Residue
A	LYS28
A	TRP449
B	ARG102
B	TYR108
B	TYR110
B	ILE126
B	ASN145
B	HIS148
B	GLN152
B	HIS190
B	PHE192
B	FE501
B	HOH621

site_id	AC6
Number of Residues	7
Details	binding site for residue FMT B 504

Chain	Residue
A	PHE433
B	PHE236
B	ALA242
B	PRO303
B	ASN304
B	HOH615
B	HOH650

site_id	AC7
Number of Residues	5
Details	binding site for residue FE C 501

Chain	Residue
C	HIS148
C	GLN152
C	HIS190
C	2HE502
C	HOH601

site_id	AC8
Number of Residues	14
Details	binding site for residue 2HE C 502

Chain	Residue
C	ARG102
C	TYR108
C	TYR110
C	ILE126
C	ASN145
C	HIS148
C	GLN152
C	HIS190
C	PHE192
C	FE501
C	HOH601
C	HOH635
D	LYS28
D	TRP449

site_id	AC9
Number of Residues	8
Details	binding site for residue FMT C 503

Chain	Residue
C	PHE236
C	ALA242
C	PRO303
C	ASN304
C	HOH631
C	HOH688
C	HOH697
D	PHE433

site_id	AD1
Number of Residues	5
Details	binding site for residue FE D 501

Chain	Residue
D	HIS148
D	GLN152
D	HIS190
D	2HE502
D	HOH601

site_id	AD2
Number of Residues	14
Details	binding site for residue 2HE D 502

Chain	Residue
C	LYS28
C	TRP449
D	ARG102
D	TYR108
D	TYR110
D	ILE126
D	ASN145
D	HIS148
D	GLN152
D	HIS190
D	PHE192
D	FE501
D	HOH601
D	HOH665

site_id	AD3
Number of Residues	7
Details	binding site for residue FMT D 503

Chain	Residue
D	ASN304
D	HOH634
D	HOH683
C	PHE433
D	PHE236
D	ALA242
D	PRO303

site_id	AD4
Number of Residues	6
Details	binding site for residue FE E 501

Chain	Residue
E	HIS148
E	GLN152
E	HIS190
E	2HE502
E	HOH608
F	LYS28

site_id	AD5
Number of Residues	14
Details	binding site for residue 2HE E 502

Chain	Residue
E	ARG102
E	TYR108
E	TYR110
E	ILE126
E	ASN145
E	HIS148
E	GLN152
E	HIS190
E	PHE192
E	FE501
E	HOH608
E	HOH655
F	LYS28
F	TRP449

site_id	AD6
Number of Residues	8
Details	binding site for residue FMT E 503

Chain	Residue
E	PHE236
E	ALA242
E	PRO303
E	ASN304
E	HOH623
E	HOH625
E	HOH654
F	PHE433

site_id	AD7
Number of Residues	5
Details	binding site for residue FE F 501

Chain	Residue
F	HIS148
F	GLN152
F	HIS190
F	2HE502
F	HOH601

site_id	AD8
Number of Residues	13
Details	binding site for residue 2HE F 502

Chain	Residue
E	LYS28
E	TRP449
F	ARG102
F	TYR110
F	ILE126
F	ASN145
F	HIS148
F	GLN152
F	HIS190
F	PHE192
F	FE501
F	HOH601
F	HOH616

site_id	AD9
Number of Residues	6
Details	binding site for residue FMT F 503

Chain	Residue
E	PHE433
F	PHE236
F	PRO303
F	ASN304
F	HOH608
F	HOH656

site_id	AE1
Number of Residues	5
Details	binding site for residue FE G 501

Chain	Residue
G	HIS148
G	GLN152
G	HIS190
G	2HE502
H	LYS28

site_id	AE2
Number of Residues	12
Details	binding site for residue 2HE G 502

Chain	Residue
G	ARG102
G	TYR108
G	TYR110
G	ILE126
G	ASN145
G	HIS148
G	GLN152
G	HIS190
G	PHE192
G	FE501
H	LYS28
H	TRP449

site_id	AE3
Number of Residues	5
Details	binding site for residue FMT G 503

Chain	Residue
G	PHE236
G	PRO303
G	ASN304
G	HOH617
H	PHE433

site_id	AE4
Number of Residues	6
Details	binding site for residue FE H 501

Chain	Residue
G	LYS28
H	HIS148
H	GLN152
H	HIS190
H	2HE502
H	HOH601

site_id	AE5
Number of Residues	13
Details	binding site for residue 2HE H 502

Chain	Residue
G	LYS28
G	TRP449
H	ARG102
H	TYR110
H	ILE126
H	ASN145
H	HIS148
H	GLN152
H	HIS190
H	PHE192
H	FE501
H	HOH601
H	HOH654

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	408
Details	Domain: {"description":"HTH cro/C1-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	432
Details	Domain: {"description":"HTH cro/C1-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	296
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)