6B8S
Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA66 |
| A | THR242 |
| A | ASN243 |
| A | SER261 |
| A | GLY262 |
| A | LEU265 |
| A | VAL289 |
| A | GLY290 |
| A | GLY291 |
| A | ILE311 |
| A | TYR312 |
| A | ALA67 |
| A | SER313 |
| A | HOH505 |
| A | HOH523 |
| A | GLY68 |
| A | LYS71 |
| A | THR91 |
| A | ASN116 |
| A | ASN145 |
| A | ASN178 |
| A | LYS214 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 402 |
| Chain | Residue |
| A | TYR3 |
| A | HIS19 |
| A | PHE315 |
| A | ILE316 |
| A | HOH526 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue FMN B 401 |
| Chain | Residue |
| B | ALA66 |
| B | ALA67 |
| B | GLY68 |
| B | THR91 |
| B | ASN116 |
| B | ASN145 |
| B | ASN178 |
| B | LYS214 |
| B | THR242 |
| B | ASN243 |
| B | SER261 |
| B | GLY262 |
| B | LEU265 |
| B | VAL289 |
| B | GLY290 |
| B | GLY291 |
| B | TYR312 |
| B | SER313 |
| B | HOH508 |
| B | HOH509 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue PGE B 402 |
| Chain | Residue |
| B | SER32 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00225 |
| Chain | Residue | Details |
| A | SER181 | |
| B | SER181 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00225 |
| Chain | Residue | Details |
| A | ALA67 | |
| A | ASN243 | |
| A | GLY262 | |
| A | GLY291 | |
| A | TYR312 | |
| B | ALA67 | |
| B | LYS71 | |
| B | THR91 | |
| B | ASN116 | |
| B | ASN145 | |
| B | ASN178 | |
| A | LYS71 | |
| B | ASN183 | |
| B | LYS214 | |
| B | THR242 | |
| B | ASN243 | |
| B | GLY262 | |
| B | GLY291 | |
| B | TYR312 | |
| A | THR91 | |
| A | ASN116 | |
| A | ASN145 | |
| A | ASN178 | |
| A | ASN183 | |
| A | LYS214 | |
| A | THR242 |
