6B8S

Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity
B	0004152	molecular_function	dihydroorotate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue FMN A 401

Chain	Residue
A	ALA66
A	THR242
A	ASN243
A	SER261
A	GLY262
A	LEU265
A	VAL289
A	GLY290
A	GLY291
A	ILE311
A	TYR312
A	ALA67
A	SER313
A	HOH505
A	HOH523
A	GLY68
A	LYS71
A	THR91
A	ASN116
A	ASN145
A	ASN178
A	LYS214

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PGE A 402

Chain	Residue
A	TYR3
A	HIS19
A	PHE315
A	ILE316
A	HOH526

---

site_id	AC3
Number of Residues	20
Details	binding site for residue FMN B 401

Chain	Residue
B	ALA66
B	ALA67
B	GLY68
B	THR91
B	ASN116
B	ASN145
B	ASN178
B	LYS214
B	THR242
B	ASN243
B	SER261
B	GLY262
B	LEU265
B	VAL289
B	GLY290
B	GLY291
B	TYR312
B	SER313
B	HOH508
B	HOH509

---

site_id	AC4
Number of Residues	1
Details	binding site for residue PGE B 402

Chain	Residue
B	SER32

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Functional Information from PROSITE/UniProt

site_id	PS00911
Number of Residues	20
Details	DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GyleaGTLTneaQvGNerPR

Chain	Residue	Details
A	GLY85-ARG104

---

site_id	PS00912
Number of Residues	21
Details	DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. LVSvGGIsDakeAyeRIkMGA

Chain	Residue	Details
A	LEU286-ALA306

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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