6B7I

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (2S)-2-(3,5-difluorophenyl)-2-hydroxyacetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0047975	molecular_function	guanosine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue DMS A 301

Chain	Residue
A	ASN95
A	ALA99
A	ARG103
A	VAL148
A	VAL150
A	HOH446
A	HOH468

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site_id	AC2
Number of Residues	4
Details	binding site for residue DMS A 302

Chain	Residue
A	CYS231
A	HIS232
A	PRO162
A	ASP163

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site_id	AC3
Number of Residues	6
Details	binding site for residue DMS A 303

Chain	Residue
A	SER35
A	ARG86
A	HIS88
A	LEU118
A	SER222
A	DMS305

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site_id	AC4
Number of Residues	3
Details	binding site for residue DMS A 304

Chain	Residue
A	VAL63
A	TYR93
A	HOH599

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site_id	AC5
Number of Residues	5
Details	binding site for residue DMS A 305

Chain	Residue
A	TYR202
A	MET221
A	HIS259
A	DMS303
A	HOH449

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site_id	AC6
Number of Residues	4
Details	binding site for residue DMS A 306

Chain	Residue
A	LYS106
A	GLU156
A	PHE157
A	HOH480

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site_id	AC7
Number of Residues	2
Details	binding site for residue DMS A 307

Chain	Residue
A	VAL189
A	HOH548

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site_id	AC8
Number of Residues	6
Details	binding site for residue CXJ A 308

Chain	Residue
A	LEU171
A	GLN174
A	LEU175
A	LYS178
A	ARG283
A	PRO285

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