6B6X
Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase, dithionite-reduced (protein batch 2), canonical C-cluster
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| A | 0050418 | molecular_function | hydroxylamine reductase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| B | 0050418 | molecular_function | hydroxylamine reductase activity |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 A 701 |
| Chain | Residue |
| A | CYS51 |
| A | CYS54 |
| A | CYS59 |
| A | CYS74 |
| A | ARG84 |
| A | MET203 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue XCC A 702 |
| Chain | Residue |
| A | HIS319 |
| A | CYS340 |
| A | GLY447 |
| A | CYS448 |
| A | CYS478 |
| A | CYS519 |
| A | TYR553 |
| A | SER554 |
| A | LYS556 |
| A | HOH884 |
| A | HIS266 |
| A | CYS301 |
| A | CYS302 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 703 |
| Chain | Residue |
| A | ASP79 |
| A | GLY581 |
| A | SER582 |
| A | GLU583 |
| A | ASN584 |
| A | HOH831 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 704 |
| Chain | Residue |
| A | HOH895 |
| A | HOH919 |
| A | HOH953 |
| A | HOH1090 |
| A | HOH1183 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 705 |
| Chain | Residue |
| A | HOH815 |
| A | HOH1083 |
| A | HOH1227 |
| B | HOH839 |
| B | HOH1212 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 706 |
| Chain | Residue |
| A | ARG64 |
| A | LYS65 |
| B | ALA144 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FES B 701 |
| Chain | Residue |
| A | CYS42 |
| A | CYS45 |
| A | THR50 |
| B | CYS42 |
| B | CYS45 |
| B | THR50 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 B 702 |
| Chain | Residue |
| B | CYS51 |
| B | CYS54 |
| B | CYS59 |
| B | CYS74 |
| B | ARG84 |
| B | MET203 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue XCC B 703 |
| Chain | Residue |
| B | HIS266 |
| B | CYS301 |
| B | CYS302 |
| B | HIS319 |
| B | CYS340 |
| B | GLY447 |
| B | CYS448 |
| B | CYS478 |
| B | CYS519 |
| B | TYR553 |
| B | SER554 |
| B | LYS556 |
| B | HOH820 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 704 |
| Chain | Residue |
| A | CYS42 |
| A | PHE44 |
| A | ARG60 |
| B | CYS42 |
| B | PHE44 |
| B | ARG60 |
| B | ASP138 |
| B | HOH951 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 705 |
| Chain | Residue |
| B | GLY135 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 706 |
| Chain | Residue |
| B | ALA78 |
| B | ASP79 |
| B | GLY581 |
| B | SER582 |
| B | GLU583 |
| B | ASN584 |
| B | HOH993 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 707 |
| Chain | Residue |
| A | PRO361 |
| B | GLY184 |
| B | ARG200 |
| B | SER211 |
| B | ARG218 |
| B | HOH839 |
| B | HOH877 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 708 |
| Chain | Residue |
| B | ASP103 |
| B | TYR338 |
| B | THR359 |
| B | SER360 |
| B | PRO361 |
| B | VAL373 |
| B | HOH817 |
| B | HOH826 |
| B | HOH969 |
| B | HOH1041 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 709 |
| Chain | Residue |
| B | HOH1156 |
| B | HOH1203 |
| B | HOH1275 |
| B | HOH864 |
| B | HOH904 |
| B | HOH944 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 710 |
| Chain | Residue |
| A | HOH1175 |
| A | HOH1212 |
| B | HOH827 |
| B | HOH867 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 711 |
| Chain | Residue |
| B | ARG163 |
| B | ASN164 |
| B | ALA165 |
| B | HOH1154 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 712 |
| Chain | Residue |
| B | GLN594 |
| B | HIS617 |
| B | ARG621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Motif: {"description":"CXXC; D cluster binding","evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32655979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31296570","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OND","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR005023-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31296570","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35278753","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TSJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR005023-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32655979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VWY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Binds C cluster in the oxidized state, but not in the canonical reduced state","evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
