6B6A

Beta-Lactamase, 2secs timepoint, mixed, shards crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0008800	molecular_function	beta-lactamase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0008800	molecular_function	beta-lactamase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0008800	molecular_function	beta-lactamase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0008800	molecular_function	beta-lactamase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0042597	cellular_component	periplasmic space
D	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 A 301

Chain	Residue
A	SER70
A	SER128
A	LYS236
A	THR237
A	GLY238
A	THR239
B	GLN109

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 9F2 A 302

Chain	Residue
A	ASN216
A	THR217
A	HOH404
A	HOH414
B	ILE103
B	PRO105
B	TYR127
B	THR217
B	THR218
B	ASP241
B	9F2301
B	FZS302
A	ARG126
A	TYR127

---

site_id	AC3
Number of Residues	15
Details	binding site for residue 9F2 B 301

Chain	Residue
A	GLN109
A	9F2302
B	SER70
B	SER128
B	PRO169
B	ASN172
B	THR218
B	LYS236
B	THR237
B	GLY238
B	THR239
B	GLY240
B	ASP241
B	FZS302
B	HOH455

---

site_id	AC4
Number of Residues	16
Details	binding site for residue FZS B 302

Chain	Residue
A	GLN109
A	9F2302
B	CYS69
B	SER70
B	SER128
B	PRO169
B	ASN172
B	LYS236
B	THR237
B	GLY238
B	THR239
B	GLY240
B	ASP241
B	9F2301
B	HOH406
B	HOH455

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PO4 C 301

Chain	Residue
C	SER70
C	SER128
C	LYS236
C	THR237
C	THR239
D	GLN109

---

site_id	AC6
Number of Residues	12
Details	binding site for residue 9F2 C 302

Chain	Residue
C	ARG126
C	TYR127
C	ASN216
C	THR217
C	HOH456
D	ILE103
D	PRO105
D	THR217
D	THR218
D	ASP241
D	9F2301
D	FZS302

---

site_id	AC7
Number of Residues	19
Details	binding site for residue 9F2 D 301

Chain	Residue
C	GLN109
C	9F2302
D	SER70
D	ILE103
D	SER128
D	PRO169
D	ASN172
D	THR218
D	LYS236
D	THR237
D	GLY238
D	THR239
D	GLY240
D	ASP241
D	GLU278
D	FZS302
D	HOH404
D	HOH421
D	HOH451

---

site_id	AC8
Number of Residues	19
Details	binding site for residue FZS D 302

Chain	Residue
D	THR237
D	GLY238
D	THR239
D	GLY240
D	ASP241
D	9F2301
D	HOH404
D	HOH414
D	HOH421
C	GLN109
C	9F2302
D	CYS69
D	SER70
D	LYS73
D	ILE103
D	SER128
D	PRO169
D	ASN172
D	LYS236

---

Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL

Chain	Residue	Details
A	PHE66-LEU81

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Increases nucleophilicity of active site Ser","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site","evidences":[{"source":"PubMed","id":"24023821","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---