6B68
Beta-Lactamase, 100ms timepoint, mixed, shards crystal form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0033250 | molecular_function | penicillinase activity |
| A | 0033251 | molecular_function | cephalosporinase activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0033250 | molecular_function | penicillinase activity |
| B | 0033251 | molecular_function | cephalosporinase activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| C | 0033250 | molecular_function | penicillinase activity |
| C | 0033251 | molecular_function | cephalosporinase activity |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0016020 | cellular_component | membrane |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| D | 0033250 | molecular_function | penicillinase activity |
| D | 0033251 | molecular_function | cephalosporinase activity |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | SER70 |
| A | SER128 |
| A | LYS236 |
| A | THR237 |
| A | GLY238 |
| A | THR239 |
| B | GLN109 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 9F2 A 302 |
| Chain | Residue |
| A | ASN216 |
| A | THR217 |
| A | HOH470 |
| B | PRO105 |
| B | TYR127 |
| B | THR217 |
| B | THR218 |
| B | 9F2301 |
| B | FZS302 |
| A | ARG126 |
| A | TYR127 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue 9F2 B 301 |
| Chain | Residue |
| A | GLN109 |
| A | 9F2302 |
| B | SER70 |
| B | SER128 |
| B | PRO169 |
| B | ASN172 |
| B | THR218 |
| B | LYS236 |
| B | THR237 |
| B | GLY238 |
| B | THR239 |
| B | GLY240 |
| B | FZS302 |
| B | HOH451 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue FZS B 302 |
| Chain | Residue |
| A | GLN109 |
| A | 9F2302 |
| B | CYS69 |
| B | SER70 |
| B | SER128 |
| B | PRO169 |
| B | ASN172 |
| B | LYS236 |
| B | THR237 |
| B | GLY238 |
| B | THR239 |
| B | GLY240 |
| B | 9F2301 |
| B | HOH413 |
| B | HOH451 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 301 |
| Chain | Residue |
| C | SER70 |
| C | SER128 |
| C | LYS236 |
| C | THR237 |
| C | THR239 |
| D | GLN109 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 9F2 C 302 |
| Chain | Residue |
| C | ARG126 |
| C | TYR127 |
| C | THR217 |
| C | HOH437 |
| D | THR217 |
| D | THR218 |
| D | ASP241 |
| D | 9F2400 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue 9F2 D 400 |
| Chain | Residue |
| C | 9F2302 |
| D | SER70 |
| D | SER128 |
| D | PRO169 |
| D | ASN172 |
| D | ARG173 |
| D | THR218 |
| D | LYS236 |
| D | THR237 |
| D | GLY238 |
| D | THR239 |
| D | GLY240 |
| D | ASP241 |
| D | GLU278 |
| D | HOH504 |
| D | HOH542 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
| Chain | Residue | Details |
| A | SER70 | |
| B | SER70 | |
| C | SER70 | |
| D | SER70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
| Chain | Residue | Details |
| A | GLU168 | |
| B | GLU168 | |
| C | GLU168 | |
| D | GLU168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
| Chain | Residue | Details |
| C | SER128 | |
| C | THR237 | |
| D | SER128 | |
| D | THR237 | |
| A | SER128 | |
| A | THR237 | |
| B | SER128 | |
| B | THR237 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
| Chain | Residue | Details |
| A | LYS73 | |
| B | LYS73 | |
| C | LYS73 | |
| D | LYS73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 |
| Chain | Residue | Details |
| A | ILE103 | |
| B | ILE103 | |
| C | ILE103 | |
| D | ILE103 |
