6B56
Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 5-butylpyridine-2-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 301 |
| Chain | Residue |
| A | ASN95 |
| A | ALA99 |
| A | ARG103 |
| A | VAL148 |
| A | VAL150 |
| A | HOH425 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 302 |
| Chain | Residue |
| A | HIS232 |
| A | PRO162 |
| A | ASP163 |
| A | CYS231 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 303 |
| Chain | Residue |
| A | LEU118 |
| A | PHE161 |
| A | TYR202 |
| A | MET221 |
| A | HIS259 |
| A | VAL262 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue CQV A 304 |
| Chain | Residue |
| A | ILE53 |
| A | LYS60 |
| A | THR61 |
| A | THR62 |
| A | ASN183 |
| A | PHE185 |
| A | LEU272 |
| A | MET275 |
| A | HOH445 |
| A | HOH464 |
