6B2Z

Cryo-EM structure of the dimeric FO region of yeast mitochondrial ATP synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0005739	cellular_component	mitochondrion
0	0005743	cellular_component	mitochondrial inner membrane
0	0005758	cellular_component	mitochondrial intermembrane space
0	0005829	cellular_component	cytosol
0	0015078	molecular_function	proton transmembrane transporter activity
0	0015986	biological_process	proton motive force-driven ATP synthesis
0	0016887	molecular_function	ATP hydrolysis activity
0	0031966	cellular_component	mitochondrial membrane
0	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
0	0042802	molecular_function	identical protein binding
0	0045259	cellular_component	proton-transporting ATP synthase complex
0	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
0	1902600	biological_process	proton transmembrane transport
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0005758	cellular_component	mitochondrial intermembrane space
1	0005829	cellular_component	cytosol
1	0015078	molecular_function	proton transmembrane transporter activity
1	0015986	biological_process	proton motive force-driven ATP synthesis
1	0016887	molecular_function	ATP hydrolysis activity
1	0031966	cellular_component	mitochondrial membrane
1	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
1	0042802	molecular_function	identical protein binding
1	0045259	cellular_component	proton-transporting ATP synthase complex
1	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
1	1902600	biological_process	proton transmembrane transport
2	0005739	cellular_component	mitochondrion
2	0005743	cellular_component	mitochondrial inner membrane
2	0005758	cellular_component	mitochondrial intermembrane space
2	0005829	cellular_component	cytosol
2	0015078	molecular_function	proton transmembrane transporter activity
2	0015986	biological_process	proton motive force-driven ATP synthesis
2	0016887	molecular_function	ATP hydrolysis activity
2	0031966	cellular_component	mitochondrial membrane
2	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
2	0042802	molecular_function	identical protein binding
2	0045259	cellular_component	proton-transporting ATP synthase complex
2	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
2	1902600	biological_process	proton transmembrane transport
3	0005739	cellular_component	mitochondrion
3	0005743	cellular_component	mitochondrial inner membrane
3	0005758	cellular_component	mitochondrial intermembrane space
3	0005829	cellular_component	cytosol
3	0015078	molecular_function	proton transmembrane transporter activity
3	0015986	biological_process	proton motive force-driven ATP synthesis
3	0016887	molecular_function	ATP hydrolysis activity
3	0031966	cellular_component	mitochondrial membrane
3	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
3	0042802	molecular_function	identical protein binding
3	0045259	cellular_component	proton-transporting ATP synthase complex
3	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
3	1902600	biological_process	proton transmembrane transport
4	0005739	cellular_component	mitochondrion
4	0005743	cellular_component	mitochondrial inner membrane
4	0005758	cellular_component	mitochondrial intermembrane space
4	0005829	cellular_component	cytosol
4	0015078	molecular_function	proton transmembrane transporter activity
4	0015986	biological_process	proton motive force-driven ATP synthesis
4	0016887	molecular_function	ATP hydrolysis activity
4	0031966	cellular_component	mitochondrial membrane
4	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
4	0042802	molecular_function	identical protein binding
4	0045259	cellular_component	proton-transporting ATP synthase complex
4	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
4	1902600	biological_process	proton transmembrane transport
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0005758	cellular_component	mitochondrial intermembrane space
5	0005829	cellular_component	cytosol
5	0015078	molecular_function	proton transmembrane transporter activity
5	0015986	biological_process	proton motive force-driven ATP synthesis
5	0016887	molecular_function	ATP hydrolysis activity
5	0031966	cellular_component	mitochondrial membrane
5	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
5	0042802	molecular_function	identical protein binding
5	0045259	cellular_component	proton-transporting ATP synthase complex
5	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
5	1902600	biological_process	proton transmembrane transport
6	0005739	cellular_component	mitochondrion
6	0005743	cellular_component	mitochondrial inner membrane
6	0005758	cellular_component	mitochondrial intermembrane space
6	0005829	cellular_component	cytosol
6	0015078	molecular_function	proton transmembrane transporter activity
6	0015986	biological_process	proton motive force-driven ATP synthesis
6	0016887	molecular_function	ATP hydrolysis activity
6	0031966	cellular_component	mitochondrial membrane
6	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
6	0042802	molecular_function	identical protein binding
6	0045259	cellular_component	proton-transporting ATP synthase complex
6	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
6	1902600	biological_process	proton transmembrane transport
7	0005739	cellular_component	mitochondrion
7	0005743	cellular_component	mitochondrial inner membrane
7	0005758	cellular_component	mitochondrial intermembrane space
7	0005829	cellular_component	cytosol
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0016887	molecular_function	ATP hydrolysis activity
7	0031966	cellular_component	mitochondrial membrane
7	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
7	0042802	molecular_function	identical protein binding
7	0045259	cellular_component	proton-transporting ATP synthase complex
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	1902600	biological_process	proton transmembrane transport
8	0005739	cellular_component	mitochondrion
8	0005743	cellular_component	mitochondrial inner membrane
8	0005758	cellular_component	mitochondrial intermembrane space
8	0005829	cellular_component	cytosol
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0016887	molecular_function	ATP hydrolysis activity
8	0031966	cellular_component	mitochondrial membrane
8	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
8	0042802	molecular_function	identical protein binding
8	0045259	cellular_component	proton-transporting ATP synthase complex
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	1902600	biological_process	proton transmembrane transport
9	0005739	cellular_component	mitochondrion
9	0005743	cellular_component	mitochondrial inner membrane
9	0005758	cellular_component	mitochondrial intermembrane space
9	0005829	cellular_component	cytosol
9	0015078	molecular_function	proton transmembrane transporter activity
9	0015986	biological_process	proton motive force-driven ATP synthesis
9	0016887	molecular_function	ATP hydrolysis activity
9	0031966	cellular_component	mitochondrial membrane
9	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
9	0042802	molecular_function	identical protein binding
9	0045259	cellular_component	proton-transporting ATP synthase complex
9	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
9	1902600	biological_process	proton transmembrane transport
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0015078	molecular_function	proton transmembrane transporter activity
a	0015986	biological_process	proton motive force-driven ATP synthesis
a	0045259	cellular_component	proton-transporting ATP synthase complex
a	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
a	1902600	biological_process	proton transmembrane transport
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0015078	molecular_function	proton transmembrane transporter activity
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0031966	cellular_component	mitochondrial membrane
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
b	0015078	molecular_function	proton transmembrane transporter activity
b	0015986	biological_process	proton motive force-driven ATP synthesis
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0015078	molecular_function	proton transmembrane transporter activity
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016887	molecular_function	ATP hydrolysis activity
B	0031966	cellular_component	mitochondrial membrane
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0042802	molecular_function	identical protein binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0015078	molecular_function	proton transmembrane transporter activity
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016887	molecular_function	ATP hydrolysis activity
C	0031966	cellular_component	mitochondrial membrane
C	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
C	0042802	molecular_function	identical protein binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0015078	molecular_function	proton transmembrane transporter activity
d	0015986	biological_process	proton motive force-driven ATP synthesis
d	0045259	cellular_component	proton-transporting ATP synthase complex
d	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0015078	molecular_function	proton transmembrane transporter activity
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016887	molecular_function	ATP hydrolysis activity
D	0031966	cellular_component	mitochondrial membrane
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0042802	molecular_function	identical protein binding
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0015078	molecular_function	proton transmembrane transporter activity
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0031966	cellular_component	mitochondrial membrane
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0042802	molecular_function	identical protein binding
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0015986	biological_process	proton motive force-driven ATP synthesis
f	0016887	molecular_function	ATP hydrolysis activity
f	0045259	cellular_component	proton-transporting ATP synthase complex
f	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0015078	molecular_function	proton transmembrane transporter activity
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0031966	cellular_component	mitochondrial membrane
F	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
F	0042802	molecular_function	identical protein binding
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005829	cellular_component	cytosol
G	0015078	molecular_function	proton transmembrane transporter activity
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016887	molecular_function	ATP hydrolysis activity
G	0031966	cellular_component	mitochondrial membrane
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0042802	molecular_function	identical protein binding
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005829	cellular_component	cytosol
H	0015078	molecular_function	proton transmembrane transporter activity
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016887	molecular_function	ATP hydrolysis activity
H	0031966	cellular_component	mitochondrial membrane
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0042802	molecular_function	identical protein binding
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0015078	molecular_function	proton transmembrane transporter activity
i	0015986	biological_process	proton motive force-driven ATP synthesis
i	0031966	cellular_component	mitochondrial membrane
i	0033615	biological_process	mitochondrial proton-transporting ATP synthase complex assembly
i	0045259	cellular_component	proton-transporting ATP synthase complex
i	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
i	0065003	biological_process	protein-containing complex assembly
i	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005829	cellular_component	cytosol
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016887	molecular_function	ATP hydrolysis activity
I	0031966	cellular_component	mitochondrial membrane
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0042802	molecular_function	identical protein binding
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0005829	cellular_component	cytosol
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016887	molecular_function	ATP hydrolysis activity
J	0031966	cellular_component	mitochondrial membrane
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0042802	molecular_function	identical protein binding
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0015986	biological_process	proton motive force-driven ATP synthesis
k	0045259	cellular_component	proton-transporting ATP synthase complex
k	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
k	0065003	biological_process	protein-containing complex assembly
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016887	molecular_function	ATP hydrolysis activity
K	0031966	cellular_component	mitochondrial membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0042802	molecular_function	identical protein binding
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0031966	cellular_component	mitochondrial membrane
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0031966	cellular_component	mitochondrial membrane
S	0033615	biological_process	mitochondrial proton-transporting ATP synthase complex assembly
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0065003	biological_process	protein-containing complex assembly
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0045259	cellular_component	proton-transporting ATP synthase complex
T	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
T	0065003	biological_process	protein-containing complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLGSNI

Chain	Residue	Details
M	SER172-ILE181

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPsikdtVfPmaILgfaLsE

Chain	Residue	Details
1	SER38-GLU59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1110
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Site: {"description":"Reversibly protonated during proton transport","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Modified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"2894987","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---