6B2M
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006163 | biological_process | purine nucleotide metabolic process |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006163 | biological_process | purine nucleotide metabolic process |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006163 | biological_process | purine nucleotide metabolic process |
| C | 0016783 | molecular_function | sulfurtransferase activity |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006163 | biological_process | purine nucleotide metabolic process |
| D | 0016783 | molecular_function | sulfurtransferase activity |
| D | 0016829 | molecular_function | lyase activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006163 | biological_process | purine nucleotide metabolic process |
| E | 0016783 | molecular_function | sulfurtransferase activity |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006163 | biological_process | purine nucleotide metabolic process |
| F | 0016783 | molecular_function | sulfurtransferase activity |
| F | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue COA A 501 |
| Chain | Residue |
| A | ALA24 |
| A | TRP97 |
| A | ALA100 |
| A | LYS101 |
| A | PHE104 |
| A | ASP122 |
| A | GLY123 |
| A | MET124 |
| A | HOH605 |
| A | HOH619 |
| A | PHE25 |
| A | SER26 |
| A | GLY28 |
| A | ASP30 |
| A | SER31 |
| A | VAL50 |
| A | ALA52 |
| A | TYR83 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | SER180 |
| A | ARG212 |
| A | ARG214 |
| A | ARG259 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue COA B 501 |
| Chain | Residue |
| B | ALA24 |
| B | PHE25 |
| B | SER26 |
| B | GLY28 |
| B | ASP30 |
| B | SER31 |
| B | VAL50 |
| B | ALA52 |
| B | TYR83 |
| B | TRP97 |
| B | LYS101 |
| B | PHE104 |
| B | ASP122 |
| B | GLY123 |
| B | HOH601 |
| B | HOH605 |
| B | HOH610 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 502 |
| Chain | Residue |
| B | SER180 |
| B | ARG212 |
| B | ARG214 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue COA C 501 |
| Chain | Residue |
| C | ALA24 |
| C | PHE25 |
| C | SER26 |
| C | GLY28 |
| C | ASP30 |
| C | SER31 |
| C | VAL50 |
| C | VAL51 |
| C | ALA52 |
| C | PHE57 |
| C | TYR83 |
| C | TRP97 |
| C | LYS101 |
| C | PHE104 |
| C | TYR105 |
| C | ASP122 |
| C | GLY123 |
| C | HOH602 |
| C | HOH606 |
| C | HOH615 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 C 502 |
| Chain | Residue |
| C | SER180 |
| C | ARG212 |
| C | ARG214 |
| C | ARG259 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue COA D 501 |
| Chain | Residue |
| D | ALA24 |
| D | PHE25 |
| D | SER26 |
| D | ASP30 |
| D | SER31 |
| D | VAL50 |
| D | VAL51 |
| D | ALA52 |
| D | TYR83 |
| D | TRP97 |
| D | LYS101 |
| D | PHE104 |
| D | TYR105 |
| D | ASP122 |
| D | GLY123 |
| D | HOH612 |
| D | HOH637 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 502 |
| Chain | Residue |
| D | SER180 |
| D | ARG212 |
| D | ARG214 |
| D | ARG259 |
| D | HOH639 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue COA E 501 |
| Chain | Residue |
| E | LYS101 |
| E | PHE104 |
| E | ASP122 |
| E | GLY123 |
| E | MET124 |
| E | SER177 |
| E | HOH625 |
| E | HOH651 |
| E | ALA24 |
| E | PHE25 |
| E | SER26 |
| E | GLY28 |
| E | ASP30 |
| E | SER31 |
| E | VAL50 |
| E | ALA52 |
| E | TYR83 |
| E | TRP97 |
| E | ALA100 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 E 502 |
| Chain | Residue |
| E | CYS176 |
| E | SER180 |
| E | ARG212 |
| E | ARG214 |
| E | ARG259 |
| E | HOH604 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue COA F 501 |
| Chain | Residue |
| F | ALA24 |
| F | PHE25 |
| F | SER26 |
| F | GLY28 |
| F | ASP30 |
| F | SER31 |
| F | VAL50 |
| F | ALA52 |
| F | TYR83 |
| F | TRP97 |
| F | LYS101 |
| F | PHE104 |
| F | ASP122 |
| F | GLY123 |
| F | HOH601 |
| F | HOH602 |
| F | HOH607 |
| F | HOH609 |
| F | HOH665 |
| F | HOH681 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 F 502 |
| Chain | Residue |
| F | CYS176 |
| F | SER180 |
| F | ARG212 |
| F | ARG214 |
| F | ARG259 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Nucleophile and sulfur donor","evidences":[{"source":"PubMed","id":"27114550","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"2,3-didehydroalanine (Cys)","evidences":[{"source":"PubMed","id":"27114550","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
