6B2M

LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016783	molecular_function	sulfurtransferase activity
A	0016829	molecular_function	lyase activity
B	0005524	molecular_function	ATP binding
B	0016783	molecular_function	sulfurtransferase activity
B	0016829	molecular_function	lyase activity
C	0005524	molecular_function	ATP binding
C	0016783	molecular_function	sulfurtransferase activity
C	0016829	molecular_function	lyase activity
D	0005524	molecular_function	ATP binding
D	0016783	molecular_function	sulfurtransferase activity
D	0016829	molecular_function	lyase activity
E	0005524	molecular_function	ATP binding
E	0016783	molecular_function	sulfurtransferase activity
E	0016829	molecular_function	lyase activity
F	0005524	molecular_function	ATP binding
F	0016783	molecular_function	sulfurtransferase activity
F	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue COA A 501

Chain	Residue
A	ALA24
A	TRP97
A	ALA100
A	LYS101
A	PHE104
A	ASP122
A	GLY123
A	MET124
A	HOH605
A	HOH619
A	PHE25
A	SER26
A	GLY28
A	ASP30
A	SER31
A	VAL50
A	ALA52
A	TYR83

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 A 502

Chain	Residue
A	SER180
A	ARG212
A	ARG214
A	ARG259

---

site_id	AC3
Number of Residues	17
Details	binding site for residue COA B 501

Chain	Residue
B	ALA24
B	PHE25
B	SER26
B	GLY28
B	ASP30
B	SER31
B	VAL50
B	ALA52
B	TYR83
B	TRP97
B	LYS101
B	PHE104
B	ASP122
B	GLY123
B	HOH601
B	HOH605
B	HOH610

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 B 502

Chain	Residue
B	SER180
B	ARG212
B	ARG214

---

site_id	AC5
Number of Residues	20
Details	binding site for residue COA C 501

Chain	Residue
C	ALA24
C	PHE25
C	SER26
C	GLY28
C	ASP30
C	SER31
C	VAL50
C	VAL51
C	ALA52
C	PHE57
C	TYR83
C	TRP97
C	LYS101
C	PHE104
C	TYR105
C	ASP122
C	GLY123
C	HOH602
C	HOH606
C	HOH615

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 C 502

Chain	Residue
C	SER180
C	ARG212
C	ARG214
C	ARG259

---

site_id	AC7
Number of Residues	17
Details	binding site for residue COA D 501

Chain	Residue
D	ALA24
D	PHE25
D	SER26
D	ASP30
D	SER31
D	VAL50
D	VAL51
D	ALA52
D	TYR83
D	TRP97
D	LYS101
D	PHE104
D	TYR105
D	ASP122
D	GLY123
D	HOH612
D	HOH637

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 D 502

Chain	Residue
D	SER180
D	ARG212
D	ARG214
D	ARG259
D	HOH639

---

site_id	AC9
Number of Residues	19
Details	binding site for residue COA E 501

Chain	Residue
E	LYS101
E	PHE104
E	ASP122
E	GLY123
E	MET124
E	SER177
E	HOH625
E	HOH651
E	ALA24
E	PHE25
E	SER26
E	GLY28
E	ASP30
E	SER31
E	VAL50
E	ALA52
E	TYR83
E	TRP97
E	ALA100

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 E 502

Chain	Residue
E	CYS176
E	SER180
E	ARG212
E	ARG214
E	ARG259
E	HOH604

---

site_id	AD2
Number of Residues	20
Details	binding site for residue COA F 501

Chain	Residue
F	ALA24
F	PHE25
F	SER26
F	GLY28
F	ASP30
F	SER31
F	VAL50
F	ALA52
F	TYR83
F	TRP97
F	LYS101
F	PHE104
F	ASP122
F	GLY123
F	HOH601
F	HOH602
F	HOH607
F	HOH609
F	HOH665
F	HOH681

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 F 502

Chain	Residue
F	CYS176
F	SER180
F	ARG212
F	ARG214
F	ARG259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Nucleophile and sulfur donor => ECO:0000269|PubMed:27114550

Chain	Residue	Details
A	CYS176
B	CYS176
C	CYS176
D	CYS176
E	CYS176
F	CYS176

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: 2,3-didehydroalanine (Cys) => ECO:0000269|PubMed:27114550

Chain	Residue	Details
A	CYS176
B	CYS176
C	CYS176
D	CYS176
E	CYS176
F	CYS176

---