6B07
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [1-phosphono-2-(1-propylpyridin-2-yl)ethyl]phosphonic acid (inhibitor 1d)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue C6M A 401 |
| Chain | Residue |
| A | ARG104 |
| A | GLN284 |
| A | ASP287 |
| A | LYS301 |
| A | MG402 |
| A | MG403 |
| A | MG404 |
| A | HOH528 |
| A | HOH545 |
| A | HOH559 |
| A | HOH564 |
| A | ASP147 |
| A | HOH567 |
| A | HOH571 |
| A | HOH579 |
| A | HOH645 |
| A | HOH680 |
| A | ASP151 |
| A | ARG156 |
| A | GLN215 |
| A | LYS244 |
| A | THR245 |
| A | TYR248 |
| A | PHE283 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6M401 |
| A | MG403 |
| A | HOH536 |
| A | HOH545 |
| A | HOH703 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6M401 |
| A | MG402 |
| A | HOH528 |
| A | HOH680 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | ASP287 |
| A | C6M401 |
| A | HOH559 |
| A | HOH564 |
| A | HOH645 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | GLU84 |
| A | HOH538 |
| B | ARG236 |
| B | HOH654 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | MET317 |
| A | GLN320 |
| A | HOH501 |
| A | HOH628 |
| B | GLN320 |
| B | ARG321 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue C6M B 401 |
| Chain | Residue |
| B | ARG104 |
| B | ASP147 |
| B | ASP151 |
| B | ARG156 |
| B | GLN215 |
| B | LYS244 |
| B | THR245 |
| B | TYR248 |
| B | PHE283 |
| B | GLN284 |
| B | ASP287 |
| B | LYS301 |
| B | MG402 |
| B | MG403 |
| B | MG404 |
| B | HOH525 |
| B | HOH534 |
| B | HOH544 |
| B | HOH568 |
| B | HOH595 |
| B | HOH598 |
| B | HOH609 |
| B | HOH617 |
| B | HOH653 |
| B | HOH710 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6M401 |
| B | MG403 |
| B | HOH534 |
| B | HOH596 |
| B | HOH710 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6M401 |
| B | MG402 |
| B | HOH525 |
| B | HOH653 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| B | ASP287 |
| B | C6M401 |
| B | HOH568 |
| B | HOH609 |
| B | HOH617 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | PRO377 |
| B | SER378 |
| B | GLU379 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| A | HOH723 |
| B | GLU84 |
| B | HOH538 |
| A | ARG236 |
| site_id | AD4 |
| Number of Residues | 24 |
| Details | binding site for residue C6M C 401 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | ARG156 |
| C | GLN215 |
| C | LYS244 |
| C | THR245 |
| C | TYR248 |
| C | PHE283 |
| C | GLN284 |
| C | ASP287 |
| C | LYS301 |
| C | MG402 |
| C | MG403 |
| C | MG404 |
| C | HOH518 |
| C | HOH534 |
| C | HOH539 |
| C | HOH556 |
| C | HOH571 |
| C | HOH572 |
| C | HOH592 |
| C | HOH648 |
| C | HOH657 |
| C | HOH663 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6M401 |
| C | MG403 |
| C | HOH518 |
| C | HOH568 |
| C | HOH663 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 403 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6M401 |
| C | MG402 |
| C | HOH534 |
| C | HOH657 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 404 |
| Chain | Residue |
| C | ASP287 |
| C | C6M401 |
| C | HOH571 |
| C | HOH572 |
| C | HOH592 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | TYR95 |
| C | ASN96 |
| C | ASP148 |
| C | CYS161 |
| C | TRP162 |
| C | HOH523 |
| C | HOH564 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | GLU84 |
| C | HOH632 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 407 |
| Chain | Residue |
| C | PHE184 |
| C | ASN205 |
| C | GLU206 |
| C | HOH629 |
Functional Information from PROSITE/UniProt
