6B06
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with IPP and [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue C6J A 400 |
| Chain | Residue |
| A | ASP147 |
| A | MG402 |
| A | MG403 |
| A | IPE404 |
| A | HOH501 |
| A | HOH503 |
| A | HOH504 |
| A | HOH505 |
| A | HOH506 |
| A | HOH513 |
| A | ASP151 |
| A | ARG156 |
| A | LYS244 |
| A | THR245 |
| A | GLN284 |
| A | ASP287 |
| A | LYS301 |
| A | MG401 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6J400 |
| A | MG402 |
| A | HOH501 |
| A | HOH509 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6J400 |
| A | MG401 |
| A | HOH505 |
| A | HOH513 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP287 |
| A | ASP291 |
| A | ASP305 |
| A | C6J400 |
| A | HOH503 |
| A | HOH506 |
| A | HOH513 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue IPE A 404 |
| Chain | Residue |
| A | GLY100 |
| A | LYS101 |
| A | ARG104 |
| A | GLN140 |
| A | ARG157 |
| A | TYR248 |
| A | ASP287 |
| A | C6J400 |
| A | HOH512 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue C6J B 400 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | ARG156 |
| B | GLN215 |
| B | LYS244 |
| B | THR245 |
| B | GLN284 |
| B | ASP287 |
| B | LYS301 |
| B | MG401 |
| B | MG402 |
| B | MG403 |
| B | IPE404 |
| B | HOH501 |
| B | HOH506 |
| B | HOH511 |
| B | HOH513 |
| B | HOH515 |
| B | HOH518 |
| B | HOH520 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6J400 |
| B | HOH501 |
| B | HOH503 |
| B | HOH511 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6J400 |
| B | HOH515 |
| B | HOH520 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | ASP287 |
| B | C6J400 |
| B | HOH506 |
| B | HOH513 |
| B | HOH514 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue IPE B 404 |
| Chain | Residue |
| B | GLY100 |
| B | LYS101 |
| B | ARG104 |
| B | GLN140 |
| B | ARG157 |
| B | TYR248 |
| B | ASP287 |
| B | C6J400 |
| B | HOH502 |
| B | HOH522 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue C6J C 400 |
| Chain | Residue |
| C | ASP287 |
| C | LYS301 |
| C | MG401 |
| C | MG402 |
| C | MG403 |
| C | IPE404 |
| C | HOH501 |
| C | HOH502 |
| C | HOH503 |
| C | HOH504 |
| C | HOH505 |
| C | HOH509 |
| C | HOH510 |
| C | ASP147 |
| C | ASP151 |
| C | ARG156 |
| C | LYS244 |
| C | THR245 |
| C | TYR248 |
| C | GLN284 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 401 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6J400 |
| C | MG402 |
| C | HOH504 |
| C | HOH506 |
| C | HOH510 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6J400 |
| C | MG401 |
| C | HOH501 |
| C | HOH509 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 403 |
| Chain | Residue |
| C | ASP287 |
| C | C6J400 |
| C | HOH502 |
| C | HOH503 |
| C | HOH505 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue IPE C 404 |
| Chain | Residue |
| C | LYS101 |
| C | ARG104 |
| C | GLN140 |
| C | TYR248 |
| C | PHE283 |
| C | GLN284 |
| C | ASP287 |
| C | C6J400 |
Functional Information from PROSITE/UniProt
