Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AYT

Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
A	0008930	molecular_function	methylthioadenosine nucleosidase activity
A	0009086	biological_process	methionine biosynthetic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009234	biological_process	menaquinone biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
B	0008930	molecular_function	methylthioadenosine nucleosidase activity
B	0009086	biological_process	methionine biosynthetic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009234	biological_process	menaquinone biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
C	0008930	molecular_function	methylthioadenosine nucleosidase activity
C	0009086	biological_process	methionine biosynthetic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009234	biological_process	menaquinone biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
D	0008930	molecular_function	methylthioadenosine nucleosidase activity
D	0009086	biological_process	methionine biosynthetic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009234	biological_process	menaquinone biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 4EH A 301

Chain	Residue
A	ALA8
A	GLU171
A	MET172
A	GLU173
A	SER195
A	ASP196
A	PHE206
A	HOH413
D	PHE105
A	ILE50
A	VAL76
A	ALA77
A	GLY78
A	GLU150
A	PHE151
A	ILE152
A	CYS170

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 302

Chain	Residue
A	GLN97
A	GLU116
A	ILE117
A	LEU179
A	HOH416
A	HOH447
A	HOH464

site_id	AC3
Number of Residues	19
Details	binding site for residue 4EH B 301

Chain	Residue
B	ALA8
B	MET9
B	ILE50
B	VAL76
B	ALA77
B	GLY78
B	GLU150
B	PHE151
B	ILE152
B	CYS170
B	GLU171
B	MET172
B	GLU173
B	SER195
B	ASP196
B	PHE206
B	HOH413
C	PHE105
C	HOH449

site_id	AC4
Number of Residues	18
Details	binding site for residue 4EH C 301

Chain	Residue
B	ILE102
B	PHE105
C	ALA8
C	ILE50
C	VAL76
C	ALA77
C	GLY78
C	GLU150
C	PHE151
C	ILE152
C	CYS170
C	GLU171
C	MET172
C	GLU173
C	SER195
C	ASP196
C	PHE206
C	HOH420

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO C 302

Chain	Residue
C	GLN97
C	GLU116
C	ILE117
C	LEU179
C	HOH413
C	HOH418
C	HOH465

site_id	AC6
Number of Residues	17
Details	binding site for residue 4EH D 301

Chain	Residue
A	PHE105
D	ALA8
D	ILE50
D	VAL76
D	ALA77
D	GLY78
D	GLU150
D	PHE151
D	ILE152
D	CYS170
D	GLU171
D	MET172
D	GLU173
D	SER195
D	ASP196
D	PHE206
D	HOH429

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO D 302

Chain	Residue
D	GLN97
D	GLU116
D	ILE117
D	ILE119
D	LEU179
D	HOH407
D	HOH448
D	HOH459

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	GLU12
B	GLU12
C	GLU12
D	GLU12

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	ASP196
B	ASP196
C	ASP196
D	ASP196

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY78
D	GLY78
D	ILE152
D	MET172
A	ILE152
A	MET172
B	GLY78
B	ILE152
B	MET172
C	GLY78
C	ILE152
C	MET172

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)