Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AYS

Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hexylthio-DADMe-Immucillin-A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
A	0008930	molecular_function	methylthioadenosine nucleosidase activity
A	0009086	biological_process	methionine biosynthetic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009234	biological_process	menaquinone biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
B	0008930	molecular_function	methylthioadenosine nucleosidase activity
B	0009086	biological_process	methionine biosynthetic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009234	biological_process	menaquinone biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
C	0008930	molecular_function	methylthioadenosine nucleosidase activity
C	0009086	biological_process	methionine biosynthetic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009234	biological_process	menaquinone biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
D	0008930	molecular_function	methylthioadenosine nucleosidase activity
D	0009086	biological_process	methionine biosynthetic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009234	biological_process	menaquinone biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
E	0003824	molecular_function	catalytic activity
E	0005829	cellular_component	cytosol
E	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
E	0008930	molecular_function	methylthioadenosine nucleosidase activity
E	0009086	biological_process	methionine biosynthetic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009234	biological_process	menaquinone biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
E	0019509	biological_process	L-methionine salvage from methylthioadenosine
E	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
F	0003824	molecular_function	catalytic activity
F	0005829	cellular_component	cytosol
F	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
F	0008930	molecular_function	methylthioadenosine nucleosidase activity
F	0009086	biological_process	methionine biosynthetic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009234	biological_process	menaquinone biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
F	0019509	biological_process	L-methionine salvage from methylthioadenosine
F	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
G	0003824	molecular_function	catalytic activity
G	0005829	cellular_component	cytosol
G	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
G	0008930	molecular_function	methylthioadenosine nucleosidase activity
G	0009086	biological_process	methionine biosynthetic process
G	0009116	biological_process	nucleoside metabolic process
G	0009164	biological_process	nucleoside catabolic process
G	0009234	biological_process	menaquinone biosynthetic process
G	0016787	molecular_function	hydrolase activity
G	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
G	0019509	biological_process	L-methionine salvage from methylthioadenosine
G	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
H	0003824	molecular_function	catalytic activity
H	0005829	cellular_component	cytosol
H	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
H	0008930	molecular_function	methylthioadenosine nucleosidase activity
H	0009086	biological_process	methionine biosynthetic process
H	0009116	biological_process	nucleoside metabolic process
H	0009164	biological_process	nucleoside catabolic process
H	0009234	biological_process	menaquinone biosynthetic process
H	0016787	molecular_function	hydrolase activity
H	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
H	0019509	biological_process	L-methionine salvage from methylthioadenosine
H	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EDO A 301

Chain	Residue
A	GLN97
A	GLU116
A	ILE117
A	ALA175
A	LEU179
A	HOH403
A	HOH423
A	HOH494

site_id	AC2
Number of Residues	18
Details	binding site for residue HT6 A 302

Chain	Residue
A	ILE50
A	VAL76
A	ALA77
A	GLY78
A	GLU150
A	PHE151
A	ILE152
A	CYS170
A	GLU171
A	MET172
A	GLU173
A	SER195
A	ASP196
A	PHE206
A	HOH442
B	PHE105
B	HIS107
A	ALA8

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO B 301

Chain	Residue
B	GLN97
B	GLU116
B	ILE117
B	LEU179
B	HOH431
B	HOH471
B	HOH482

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO B 302

Chain	Residue
A	ASN115
A	LEU179
B	ALA29
B	ASN30
B	LYS49
B	ASN54
B	LEU57
B	HOH469

site_id	AC5
Number of Residues	18
Details	binding site for residue HT6 B 303

Chain	Residue
A	PHE105
A	PRO113
B	ALA8
B	ILE50
B	VAL76
B	ALA77
B	GLY78
B	GLU150
B	PHE151
B	ILE152
B	CYS170
B	GLU171
B	MET172
B	GLU173
B	SER195
B	ASP196
B	PHE206
B	HOH419

site_id	AC6
Number of Residues	17
Details	binding site for residue HT6 C 301

Chain	Residue
A	GLU116
C	ALA8
C	ILE50
C	VAL76
C	ALA77
C	GLY78
C	GLU150
C	PHE151
C	ILE152
C	GLU171
C	MET172
C	GLU173
C	SER195
C	ASP196
C	PHE206
C	HOH424
G	HIS107

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO D 301

Chain	Residue
D	PHE111
D	GLY114
D	ASN115
D	HOH516
F	PHE111
F	PRO113
F	GLY114

site_id	AC8
Number of Residues	20
Details	binding site for residue HT6 D 302

Chain	Residue
D	HOH440
H	PHE105
H	HIS107
H	PRO113
D	ALA8
D	MET9
D	ILE50
D	VAL76
D	ALA77
D	GLY78
D	GLU150
D	PHE151
D	ILE152
D	CYS170
D	GLU171
D	MET172
D	GLU173
D	SER195
D	ASP196
D	PHE206

site_id	AC9
Number of Residues	18
Details	binding site for residue HT6 E 301

Chain	Residue
E	ALA8
E	ILE50
E	VAL76
E	ALA77
E	GLY78
E	GLU150
E	PHE151
E	ILE152
E	CYS170
E	GLU171
E	MET172
E	GLU173
E	SER195
E	ASP196
E	PHE206
E	HOH422
F	PHE105
F	PRO113

site_id	AD1
Number of Residues	18
Details	binding site for residue HT6 F 301

Chain	Residue
E	HIS107
F	ALA8
F	ILE50
F	VAL76
F	ALA77
F	GLY78
F	GLU150
F	PHE151
F	ILE152
F	CYS170
F	GLU171
F	MET172
F	GLU173
F	SER195
F	ASP196
F	PHE206
F	HOH415
H	GLY106

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO G 301

Chain	Residue
G	GLN97
G	GLU116
G	ILE117
G	LEU179
G	HOH428
G	HOH442
G	HOH484

site_id	AD3
Number of Residues	17
Details	binding site for residue HT6 G 302

Chain	Residue
C	PHE105
G	ALA8
G	ILE50
G	VAL76
G	ALA77
G	GLY78
G	GLU150
G	PHE151
G	ILE152
G	CYS170
G	GLU171
G	MET172
G	GLU173
G	SER195
G	ASP196
G	PHE206
G	HOH409

site_id	AD4
Number of Residues	17
Details	binding site for residue HT6 H 301

Chain	Residue
D	HIS107
H	ALA8
H	ILE50
H	VAL76
H	ALA77
H	GLY78
H	GLU150
H	PHE151
H	ILE152
H	CYS170
H	GLU171
H	MET172
H	GLU173
H	SER195
H	ASP196
H	PHE206
H	HOH410

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	GLU12
B	GLU12
C	GLU12
D	GLU12
E	GLU12
F	GLU12
G	GLU12
H	GLU12

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	ASP196
B	ASP196
C	ASP196
D	ASP196
E	ASP196
F	ASP196
G	ASP196
H	ASP196

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	MET172
D	GLY78
D	ILE152
D	MET172
E	GLY78
E	ILE152
E	MET172
F	GLY78
F	ILE152
F	MET172
G	GLY78
G	ILE152
G	MET172
H	GLY78
H	ILE152
H	MET172
A	GLY78
A	ILE152
A	MET172
B	GLY78
B	ILE152
B	MET172
C	GLY78
C	ILE152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)