6AYR
Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| A | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| B | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| C | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| C | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| D | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| D | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue BIG A 301 |
| Chain | Residue |
| A | ALA8 |
| A | GLU171 |
| A | MET172 |
| A | GLU173 |
| A | SER195 |
| A | ASP196 |
| A | PHE206 |
| A | HOH410 |
| A | ILE50 |
| A | VAL76 |
| A | ALA77 |
| A | GLY78 |
| A | GLU150 |
| A | PHE151 |
| A | ILE152 |
| A | CYS170 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ASP207 |
| B | ALA104 |
| B | PHE105 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue BIG B 301 |
| Chain | Residue |
| A | PHE105 |
| B | ALA8 |
| B | ILE50 |
| B | VAL76 |
| B | ALA77 |
| B | GLY78 |
| B | GLU150 |
| B | PHE151 |
| B | ILE152 |
| B | CYS170 |
| B | GLU171 |
| B | MET172 |
| B | GLU173 |
| B | SER195 |
| B | ASP196 |
| B | PHE206 |
| B | HOH402 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue BIG C 301 |
| Chain | Residue |
| C | ALA8 |
| C | ILE50 |
| C | VAL76 |
| C | ALA77 |
| C | GLY78 |
| C | GLU150 |
| C | PHE151 |
| C | ILE152 |
| C | CYS170 |
| C | GLU171 |
| C | MET172 |
| C | GLU173 |
| C | SER195 |
| C | ASP196 |
| C | PHE206 |
| C | HOH404 |
| D | PHE105 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 302 |
| Chain | Residue |
| A | PRO113 |
| A | GLY114 |
| C | PHE111 |
| C | PRO113 |
| C | GLY114 |
| C | ASN115 |
| C | HOH407 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue BIG D 301 |
| Chain | Residue |
| D | ALA8 |
| D | ILE50 |
| D | VAL76 |
| D | ALA77 |
| D | GLY78 |
| D | GLU150 |
| D | PHE151 |
| D | ILE152 |
| D | CYS170 |
| D | GLU171 |
| D | MET172 |
| D | GLU173 |
| D | SER195 |
| D | ASP196 |
| D | PHE206 |
| D | HOH402 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 302 |
| Chain | Residue |
| A | LYS94 |
| D | ASP207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
