6AYO
Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 5'-deoxy-5'-Propyl-DADMe-Immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| A | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue C1Y A 301 |
| Chain | Residue |
| A | ALA8 |
| A | GLU171 |
| A | MET172 |
| A | GLU173 |
| A | SER195 |
| A | ASP196 |
| A | PHE206 |
| A | HOH414 |
| A | ILE50 |
| A | VAL76 |
| A | ALA77 |
| A | GLY78 |
| A | GLU150 |
| A | PHE151 |
| A | ILE152 |
| A | CYS170 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | GLN97 |
| A | GLU116 |
| A | ILE117 |
| A | LEU179 |
| A | HOH418 |
| A | HOH421 |
| A | HOH498 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue C1Y B 301 |
| Chain | Residue |
| B | ALA8 |
| B | ILE50 |
| B | VAL76 |
| B | ALA77 |
| B | GLY78 |
| B | GLU150 |
| B | PHE151 |
| B | ILE152 |
| B | CYS170 |
| B | GLU171 |
| B | MET172 |
| B | GLU173 |
| B | SER195 |
| B | ASP196 |
| B | PHE206 |
| B | HOH408 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | GLN97 |
| B | GLU116 |
| B | ILE117 |
| B | ILE119 |
| B | LEU179 |
| B | HOH412 |
| B | HOH424 |
| B | HOH481 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | GLU116 |
| B | ILE117 |
| B | PHE118 |
| B | EDO304 |
| B | HOH494 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| B | TYR47 |
| B | PHE111 |
| B | GLU116 |
| B | EDO303 |
| B | HOH490 |
| B | HOH520 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue BTB B 305 |
| Chain | Residue |
| A | GLY114 |
| B | GLU27 |
| B | ASN30 |
| B | ASN31 |
| B | THR32 |
| B | TYR47 |
| B | LYS49 |
| B | GLY114 |
| B | ASN115 |
| B | HOH439 |
| B | HOH466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
