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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6AYE

Human apo-TRPML3 channel at pH 7.4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000421cellular_componentautophagosome membrane
A0005253molecular_functionmonoatomic anion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0008289molecular_functionlipid binding
A0019722biological_processcalcium-mediated signaling
A0031410cellular_componentcytoplasmic vesicle
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0072345molecular_functionNAADP-sensitive calcium-release channel activity
A0098656biological_processmonoatomic anion transmembrane transport
B0000421cellular_componentautophagosome membrane
B0005253molecular_functionmonoatomic anion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0008289molecular_functionlipid binding
B0019722biological_processcalcium-mediated signaling
B0031410cellular_componentcytoplasmic vesicle
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0072345molecular_functionNAADP-sensitive calcium-release channel activity
B0098656biological_processmonoatomic anion transmembrane transport
C0000421cellular_componentautophagosome membrane
C0005253molecular_functionmonoatomic anion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0008289molecular_functionlipid binding
C0019722biological_processcalcium-mediated signaling
C0031410cellular_componentcytoplasmic vesicle
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0072345molecular_functionNAADP-sensitive calcium-release channel activity
C0098656biological_processmonoatomic anion transmembrane transport
D0000421cellular_componentautophagosome membrane
D0005253molecular_functionmonoatomic anion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0008289molecular_functionlipid binding
D0019722biological_processcalcium-mediated signaling
D0031410cellular_componentcytoplasmic vesicle
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035725biological_processsodium ion transmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0072345molecular_functionNAADP-sensitive calcium-release channel activity
D0098656biological_processmonoatomic anion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues484
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues228
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues100
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsRegion: {"description":"Interaction with phosphoinositides","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues56
DetailsRegion: {"description":"Extracellular/lumenal pore loop","evidences":[{"source":"UniProtKB","id":"Q9GZU1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsSite: {"description":"Interaction with phosphoinositides","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29106414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-31

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