6AW9

2.55A resolution structure of SAH bound catechol O-methyltransferase (COMT) L136M from Nannospalax galili

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006584	biological_process	catecholamine metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008171	molecular_function	O-methyltransferase activity
A	0016020	cellular_component	membrane
A	0016206	molecular_function	catechol O-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0032259	biological_process	methylation
A	0032502	biological_process	developmental process
A	0042417	biological_process	dopamine metabolic process
A	0042424	biological_process	catecholamine catabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006584	biological_process	catecholamine metabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008171	molecular_function	O-methyltransferase activity
B	0016020	cellular_component	membrane
B	0016206	molecular_function	catechol O-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0032259	biological_process	methylation
B	0032502	biological_process	developmental process
B	0042417	biological_process	dopamine metabolic process
B	0042424	biological_process	catecholamine catabolic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006584	biological_process	catecholamine metabolic process
C	0008168	molecular_function	methyltransferase activity
C	0008171	molecular_function	O-methyltransferase activity
C	0016020	cellular_component	membrane
C	0016206	molecular_function	catechol O-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0032259	biological_process	methylation
C	0032502	biological_process	developmental process
C	0042417	biological_process	dopamine metabolic process
C	0042424	biological_process	catecholamine catabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 301

Chain	Residue
A	ASP140
A	ASP168
A	ASN169
A	HOH416

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site_id	AC2
Number of Residues	18
Details	binding site for residue SAH A 302

Chain	Residue
A	TYR68
A	TYR71
A	SER72
A	GLU90
A	LYS91
A	TYR95
A	GLY117
A	ALA118
A	SER119
A	GLN120
A	ASP140
A	HIS141
A	TRP142
A	MET40
A	ASN41
A	VAL42
A	GLY66
A	ALA67

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CA B 301

Chain	Residue
B	ASP140
B	ASP168
B	ASN169
B	HOH412

---

site_id	AC4
Number of Residues	15
Details	binding site for residue SAH B 302

Chain	Residue
B	MET40
B	ASN41
B	VAL42
B	GLY66
B	TYR68
B	TYR71
B	SER72
B	GLU90
B	LYS91
B	TYR95
B	SER119
B	GLN120
B	ASP140
B	HIS141
B	TRP142

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 301

Chain	Residue
C	ASP140
C	ASP168
C	ASN169
C	GLU198
C	HOH401

---

site_id	AC6
Number of Residues	18
Details	binding site for residue SAH C 302

Chain	Residue
C	MET40
C	ASN41
C	VAL42
C	GLY66
C	ALA67
C	TYR68
C	TYR71
C	SER72
C	MET89
C	GLU90
C	LYS91
C	TYR95
C	ALA118
C	SER119
C	GLN120
C	ASP140
C	HIS141
C	TRP142

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