6AW7
2.15A resolution structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0032502 | biological_process | developmental process |
| A | 0042417 | biological_process | dopamine metabolic process |
| A | 0042424 | biological_process | catecholamine catabolic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016206 | molecular_function | catechol O-methyltransferase activity |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0032502 | biological_process | developmental process |
| B | 0042417 | biological_process | dopamine metabolic process |
| B | 0042424 | biological_process | catecholamine catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 301 |
| Chain | Residue |
| A | ASP140 |
| A | ASP168 |
| A | ASN169 |
| A | HOH437 |
| A | HOH461 |
| A | HOH463 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue SAH A 302 |
| Chain | Residue |
| A | GLY66 |
| A | ALA67 |
| A | TYR68 |
| A | TYR71 |
| A | SER72 |
| A | MET89 |
| A | GLU90 |
| A | LYS91 |
| A | TYR95 |
| A | GLY117 |
| A | ALA118 |
| A | SER119 |
| A | GLN120 |
| A | ASP140 |
| A | HIS141 |
| A | TRP142 |
| A | ARG145 |
| A | HOH413 |
| A | HOH438 |
| A | MET40 |
| A | ASN41 |
| A | VAL42 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 301 |
| Chain | Residue |
| B | ASP140 |
| B | ASP168 |
| B | ASN169 |
| B | HOH434 |
| B | HOH463 |
| B | HOH466 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue SAH B 302 |
| Chain | Residue |
| B | MET40 |
| B | ASN41 |
| B | VAL42 |
| B | GLY66 |
| B | ALA67 |
| B | TYR68 |
| B | TYR71 |
| B | SER72 |
| B | GLU90 |
| B | LYS91 |
| B | TYR95 |
| B | GLY117 |
| B | ALA118 |
| B | SER119 |
| B | GLN120 |
| B | ASP140 |
| B | HIS141 |
| B | TRP142 |
| B | HOH416 |
| B | HOH427 |
| B | HOH434 |
| B | HOH460 |
