6AW5
1.90A resolution structure of catechol O-methyltransferase (COMT) L136M (hexagonal form) from Nannospalax galili
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0032259 | biological_process | methylation |
| A | 0032502 | biological_process | developmental process |
| A | 0042417 | biological_process | dopamine metabolic process |
| A | 0042424 | biological_process | catecholamine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | VAL182 |
| A | ARG183 |
| A | SER185 |
| A | PHE188 |
| A | GLU198 |
| A | HOH448 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | TYR71 |
| A | SER72 |
| A | HIS141 |
| A | TYR68 |
| A | CYS69 |
| A | GLY70 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | GLU52 |
| A | GLU52 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | ALA96 |
| A | ALA97 |
| A | GLN100 |
| A | ILE116 |
| A | ALA180 |
| A | GLY184 |
| A | MET200 |
| A | HOH415 |
| A | HOH498 |
