6AW4
1.50A resolution structure of catechol O-methyltransferase (COMT) from Nannospalax galili
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0032259 | biological_process | methylation |
| A | 0032502 | biological_process | developmental process |
| A | 0042417 | biological_process | dopamine metabolic process |
| A | 0042424 | biological_process | catecholamine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | HIS57 |
| A | ARG160 |
| A | GLY162 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | HOH418 |
| A | HOH440 |
| A | THR4 |
| A | GLU6 |
| A | ASN92 |
| A | ASP94 |
| A | HOH402 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | VAL182 |
| A | ARG183 |
| A | SER185 |
| A | PHE188 |
| A | GLU198 |
| A | HOH494 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue TRS A 304 |
| Chain | Residue |
| A | LYS46 |
| A | TYR71 |
| A | PO4305 |
| A | HOH404 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 305 |
| Chain | Residue |
| A | ALA67 |
| A | TYR68 |
| A | CYS69 |
| A | GLY70 |
| A | TYR71 |
| A | SER72 |
| A | ASP140 |
| A | TRS304 |
| A | HOH404 |
| A | HOH444 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 306 |
| Chain | Residue |
| A | GLY83 |
| A | ARG85 |
| A | LYS111 |
| A | HOH432 |
| A | HOH437 |
| A | HOH479 |
| A | HOH480 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 307 |
| Chain | Residue |
| A | HIS192 |
| A | SER194 |
| A | TYR196 |
| A | HOH416 |
| A | HOH416 |
| A | HOH524 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 308 |
| Chain | Residue |
| A | ALA118 |
| A | SER119 |
| A | GLN120 |
| A | ARG145 |
| A | HOH415 |
| A | HOH417 |
| A | HOH556 |
