6AUJ

Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
B	0004799	molecular_function	thymidylate synthase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006231	biological_process	dTMP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0008168	molecular_function	methyltransferase activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0032259	biological_process	methylation
C	0004799	molecular_function	thymidylate synthase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006231	biological_process	dTMP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0008168	molecular_function	methyltransferase activity
C	0009165	biological_process	nucleotide biosynthetic process
C	0016741	molecular_function	transferase activity, transferring one-carbon groups
C	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PGE A 301

Chain	Residue
A	GLU66
A	TRP88
A	PHE184
A	HOH417

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site_id	AC2
Number of Residues	3
Details	binding site for residue PGE B 301

Chain	Residue
B	GLU66
B	ILE87
B	PHE184

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site_id	AC3
Number of Residues	5
Details	binding site for residue PGE C 301

Chain	Residue
C	PHE184
C	HOH409
C	HOH525
C	ILE87
C	TRP91

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Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIvsaWNvaeipnma.....LaPCHamfQFyV

Chain	Residue	Details
A	ARG134-VAL162

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