6ATQ

Crystal structure of apo-hGSTA1-1 exhibiting a new conformation of C-terminal helix

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004769	molecular_function	steroid delta-isomerase activity
A	0005504	molecular_function	fatty acid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0030855	biological_process	epithelial cell differentiation
A	0043651	biological_process	linoleic acid metabolic process
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
A	1901687	biological_process	glutathione derivative biosynthetic process
B	0004364	molecular_function	glutathione transferase activity
B	0004601	molecular_function	peroxidase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0004769	molecular_function	steroid delta-isomerase activity
B	0005504	molecular_function	fatty acid binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0016740	molecular_function	transferase activity
B	0016853	molecular_function	isomerase activity
B	0030855	biological_process	epithelial cell differentiation
B	0043651	biological_process	linoleic acid metabolic process
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification
B	1901687	biological_process	glutathione derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MPD A 301

Chain	Residue
A	MET63
A	LYS64
A	HOH426
B	LEU91
B	MET94

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site_id	AC2
Number of Residues	2
Details	binding site for residue MPD A 302

Chain	Residue
A	PHE10
A	MET208

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site_id	AC3
Number of Residues	3
Details	binding site for residue MES A 303

Chain	Residue
A	HOH434
A	PHE10
A	ARG15

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site_id	AC4
Number of Residues	5
Details	binding site for residue MPD A 304

Chain	Residue
A	LYS6
A	HIS8
A	LYS33
A	GLU59
A	HOH403

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site_id	AC5
Number of Residues	5
Details	binding site for residue MPD B 301

Chain	Residue
A	ARG131
B	ARG45
B	GLN54
B	VAL55
B	PHE220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16421451, ECO:0000269|PubMed:19618965

Chain	Residue	Details
B	TYR9
B	ARG45
B	GLN54
B	GLN67
A	TYR9
A	ARG45
A	GLN54
A	GLN67

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed => ECO:0000250|UniProtKB:P30115

Chain	Residue	Details
A	ALA2
B	ALA2

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P30115

Chain	Residue	Details
A	LYS4
B	LYS4

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