6ATO
Crystal structure of hGSTA1-1 complexed with GSH and MPD in each subunit
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0004769 | molecular_function | steroid delta-isomerase activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0043651 | biological_process | linoleic acid metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1901687 | biological_process | glutathione derivative biosynthetic process |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0004769 | molecular_function | steroid delta-isomerase activity |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0043651 | biological_process | linoleic acid metabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 1901687 | biological_process | glutathione derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue GSH A 301 |
| Chain | Residue |
| A | TYR9 |
| A | HOH417 |
| A | HOH482 |
| A | HOH500 |
| A | HOH545 |
| A | HOH588 |
| B | ASP101 |
| B | ARG131 |
| A | ARG15 |
| A | ARG45 |
| A | GLN54 |
| A | VAL55 |
| A | GLN67 |
| A | THR68 |
| A | PHE220 |
| A | MPD302 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 302 |
| Chain | Residue |
| A | TYR9 |
| A | ARG15 |
| A | GSH301 |
| A | HOH415 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MPD A 303 |
| Chain | Residue |
| A | MET63 |
| A | LYS64 |
| A | LYS141 |
| A | SER142 |
| A | HOH420 |
| B | MET94 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MPD A 304 |
| Chain | Residue |
| A | ARG45 |
| A | GLN53 |
| A | HOH561 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 305 |
| Chain | Residue |
| A | TYR49 |
| A | GLU59 |
| A | HOH416 |
| A | HOH419 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue GSH B 301 |
| Chain | Residue |
| A | ASP101 |
| A | ARG131 |
| A | HOH431 |
| B | TYR9 |
| B | ARG15 |
| B | ARG45 |
| B | GLN54 |
| B | VAL55 |
| B | GLN67 |
| B | THR68 |
| B | PHE220 |
| B | MPD302 |
| B | HOH407 |
| B | HOH500 |
| B | HOH572 |
| B | HOH578 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MPD B 302 |
| Chain | Residue |
| B | TYR9 |
| B | GSH301 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue MPD B 303 |
| Chain | Residue |
| B | SER18 |
| B | ARG69 |
| B | LEU72 |
| B | GLU97 |
| B | ALA100 |
| B | HIS159 |
| B | HOH630 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue MPD B 304 |
| Chain | Residue |
| B | ARG13 |
| B | ILE106 |
| B | TYR166 |
| B | GLU169 |
| B | PRO207 |
| B | HOH439 |
| B | HOH459 |
| B | HOH481 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16421451, ECO:0000269|PubMed:19618965 |
| Chain | Residue | Details |
| B | TYR9 | |
| B | ARG45 | |
| B | GLN54 | |
| B | GLN67 | |
| A | TYR9 | |
| A | ARG45 | |
| A | GLN54 | |
| A | GLN67 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed => ECO:0000250|UniProtKB:P30115 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P30115 |
| Chain | Residue | Details |
| A | LYS4 | |
| B | LYS4 |
