6AQZ
Crystal structure of a gdp-l-fucose synthetase from Naegleria fowleri bound to NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| A | 0050577 | molecular_function | GDP-L-fucose synthase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| B | 0050577 | molecular_function | GDP-L-fucose synthase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| C | 0050577 | molecular_function | GDP-L-fucose synthase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| D | 0050577 | molecular_function | GDP-L-fucose synthase activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| E | 0050577 | molecular_function | GDP-L-fucose synthase activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0009226 | biological_process | nucleotide-sugar biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
| F | 0050577 | molecular_function | GDP-L-fucose synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | GLY23 |
| A | ARG56 |
| A | LEU76 |
| A | ALA77 |
| A | ALA78 |
| A | CYS119 |
| A | LEU120 |
| A | SER121 |
| A | TYR150 |
| A | LYS154 |
| A | PRO182 |
| A | THR25 |
| A | THR183 |
| A | LEU185 |
| A | HIS198 |
| A | ARG332 |
| A | HOH505 |
| A | HOH510 |
| A | HOH524 |
| A | HOH527 |
| A | HOH550 |
| A | GLY26 |
| A | LEU27 |
| A | PHE28 |
| A | SER50 |
| A | GLY53 |
| A | ASP54 |
| A | LEU55 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | PHE220 |
| B | GLY221 |
| B | SER222 |
| B | GLY223 |
| B | ASP289 |
| B | GLY290 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | binding site for residue NAP C 401 |
| Chain | Residue |
| C | GLY23 |
| C | THR25 |
| C | GLY26 |
| C | LEU27 |
| C | PHE28 |
| C | GLY49 |
| C | SER50 |
| C | GLY53 |
| C | ASP54 |
| C | LEU55 |
| C | ARG56 |
| C | LEU76 |
| C | ALA77 |
| C | ALA78 |
| C | CYS119 |
| C | LEU120 |
| C | TYR150 |
| C | LYS154 |
| C | PRO182 |
| C | THR183 |
| C | LEU185 |
| C | HIS198 |
| C | ARG332 |
| C | HOH506 |
| C | HOH523 |
| C | HOH542 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | binding site for residue NAP E 401 |
| Chain | Residue |
| E | GLY23 |
| E | THR25 |
| E | GLY26 |
| E | LEU27 |
| E | PHE28 |
| E | GLY49 |
| E | SER50 |
| E | GLY53 |
| E | ASP54 |
| E | LEU55 |
| E | ARG56 |
| E | LEU76 |
| E | ALA77 |
| E | ALA78 |
| E | MET100 |
| E | CYS119 |
| E | LEU120 |
| E | SER121 |
| E | TYR150 |
| E | LYS154 |
| E | PRO182 |
| E | THR183 |
| E | LEU185 |
| E | HIS198 |
| E | ARG332 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue NAP F 401 |
| Chain | Residue |
| F | CYS119 |
| F | LEU120 |
| F | SER121 |
| F | TYR150 |
| F | LYS154 |
| F | PRO182 |
| F | THR183 |
| F | LEU185 |
| F | HIS198 |
| F | ARG332 |
| F | HOH508 |
| F | HOH510 |
| F | HOH516 |
| F | HOH528 |
| F | GLY23 |
| F | THR25 |
| F | GLY26 |
| F | LEU27 |
| F | PHE28 |
| F | GLY49 |
| F | SER50 |
| F | ASP54 |
| F | LEU55 |
| F | ARG56 |
| F | LEU76 |
| F | ALA77 |
| F | ALA78 |
| F | VAL80 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | binding site for Di-peptide NAP B 401 and PHE B 79 |
| Chain | Residue |
| B | GLY23 |
| B | GLY24 |
| B | THR25 |
| B | GLY26 |
| B | LEU27 |
| B | PHE28 |
| B | SER50 |
| B | LEU55 |
| B | ARG56 |
| B | LEU76 |
| B | ALA77 |
| B | ALA78 |
| B | VAL80 |
| B | ASP96 |
| B | ASN97 |
| B | MET100 |
| B | CYS119 |
| B | LEU120 |
| B | SER121 |
| B | TYR150 |
| B | LYS154 |
| B | PRO182 |
| B | ASN184 |
| B | LEU185 |
| B | HOH507 |
| E | TYR208 |
| E | GLN212 |
| E | ASN213 |
