6APX
Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0071702 | biological_process | organic substance transport |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1401 |
| Chain | Residue |
| A | GLY1172 |
| A | HIS1188 |
| A | ARG1292 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1402 |
| Chain | Residue |
| A | ARG1264 |
| A | HOH1513 |
| A | SER1258 |
| A | GLN1259 |
| A | ALA1260 |
| A | GLY1261 |
| A | ILE1262 |
| A | SER1263 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1403 |
| Chain | Residue |
| A | GLN72 |
| A | SER1207 |
| A | ALA1208 |
| A | ASN1209 |
| A | CYS1210 |
| A | GLU1226 |
| A | GLN1259 |
| A | ARG1264 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 1404 |
| Chain | Residue |
| A | ALA172 |
| A | ALA173 |
Functional Information from PROSITE/UniProt
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO107-ASN124 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP |
| Chain | Residue | Details |
| B | GLY37-PRO44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 |
| Chain | Residue | Details |
| A | SER1258 |
