Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AP1

Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0016887	molecular_function	ATP hydrolysis activity
A	0042802	molecular_function	identical protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0016887	molecular_function	ATP hydrolysis activity
C	0042802	molecular_function	identical protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0016887	molecular_function	ATP hydrolysis activity
D	0042802	molecular_function	identical protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0016887	molecular_function	ATP hydrolysis activity
E	0042802	molecular_function	identical protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0016887	molecular_function	ATP hydrolysis activity
F	0042802	molecular_function	identical protein binding
H	0001671	molecular_function	ATPase activator activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005771	cellular_component	multivesicular body
H	0006869	biological_process	lipid transport
H	0010008	cellular_component	endosome membrane
H	0015031	biological_process	protein transport
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
H	0045324	biological_process	late endosome to vacuole transport
H	1990621	cellular_component	ESCRT IV complex
I	0001671	molecular_function	ATPase activator activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005768	cellular_component	endosome
I	0005771	cellular_component	multivesicular body
I	0006869	biological_process	lipid transport
I	0010008	cellular_component	endosome membrane
I	0015031	biological_process	protein transport
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
I	0045324	biological_process	late endosome to vacuole transport
I	1990621	cellular_component	ESCRT IV complex
J	0001671	molecular_function	ATPase activator activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005768	cellular_component	endosome
J	0005771	cellular_component	multivesicular body
J	0006869	biological_process	lipid transport
J	0010008	cellular_component	endosome membrane
J	0015031	biological_process	protein transport
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
J	0045324	biological_process	late endosome to vacuole transport
J	1990621	cellular_component	ESCRT IV complex
K	0001671	molecular_function	ATPase activator activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005768	cellular_component	endosome
K	0005771	cellular_component	multivesicular body
K	0006869	biological_process	lipid transport
K	0010008	cellular_component	endosome membrane
K	0015031	biological_process	protein transport
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
K	0045324	biological_process	late endosome to vacuole transport
K	1990621	cellular_component	ESCRT IV complex
L	0001671	molecular_function	ATPase activator activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005768	cellular_component	endosome
L	0005771	cellular_component	multivesicular body
L	0006869	biological_process	lipid transport
L	0010008	cellular_component	endosome membrane
L	0015031	biological_process	protein transport
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
L	0045324	biological_process	late endosome to vacuole transport
L	1990621	cellular_component	ESCRT IV complex
M	0001671	molecular_function	ATPase activator activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005768	cellular_component	endosome
M	0005771	cellular_component	multivesicular body
M	0006869	biological_process	lipid transport
M	0010008	cellular_component	endosome membrane
M	0015031	biological_process	protein transport
M	0030674	molecular_function	protein-macromolecule adaptor activity
M	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
M	0045324	biological_process	late endosome to vacuole transport
M	1990621	cellular_component	ESCRT IV complex
N	0001671	molecular_function	ATPase activator activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005768	cellular_component	endosome
N	0005771	cellular_component	multivesicular body
N	0006869	biological_process	lipid transport
N	0010008	cellular_component	endosome membrane
N	0015031	biological_process	protein transport
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
N	0045324	biological_process	late endosome to vacuole transport
N	1990621	cellular_component	ESCRT IV complex
O	0001671	molecular_function	ATPase activator activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005768	cellular_component	endosome
O	0005771	cellular_component	multivesicular body
O	0006869	biological_process	lipid transport
O	0010008	cellular_component	endosome membrane
O	0015031	biological_process	protein transport
O	0030674	molecular_function	protein-macromolecule adaptor activity
O	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
O	0045324	biological_process	late endosome to vacuole transport
O	1990621	cellular_component	ESCRT IV complex
P	0001671	molecular_function	ATPase activator activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005768	cellular_component	endosome
P	0005771	cellular_component	multivesicular body
P	0006869	biological_process	lipid transport
P	0010008	cellular_component	endosome membrane
P	0015031	biological_process	protein transport
P	0030674	molecular_function	protein-macromolecule adaptor activity
P	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
P	0045324	biological_process	late endosome to vacuole transport
P	1990621	cellular_component	ESCRT IV complex
Q	0001671	molecular_function	ATPase activator activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005768	cellular_component	endosome
Q	0005771	cellular_component	multivesicular body
Q	0006869	biological_process	lipid transport
Q	0010008	cellular_component	endosome membrane
Q	0015031	biological_process	protein transport
Q	0030674	molecular_function	protein-macromolecule adaptor activity
Q	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
Q	0045324	biological_process	late endosome to vacuole transport
Q	1990621	cellular_component	ESCRT IV complex
R	0001671	molecular_function	ATPase activator activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005768	cellular_component	endosome
R	0005771	cellular_component	multivesicular body
R	0006869	biological_process	lipid transport
R	0010008	cellular_component	endosome membrane
R	0015031	biological_process	protein transport
R	0030674	molecular_function	protein-macromolecule adaptor activity
R	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
R	0045324	biological_process	late endosome to vacuole transport
R	1990621	cellular_component	ESCRT IV complex
S	0001671	molecular_function	ATPase activator activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005768	cellular_component	endosome
S	0005771	cellular_component	multivesicular body
S	0006869	biological_process	lipid transport
S	0010008	cellular_component	endosome membrane
S	0015031	biological_process	protein transport
S	0030674	molecular_function	protein-macromolecule adaptor activity
S	0032511	biological_process	late endosome to vacuole transport via multivesicular body sorting pathway
S	0045324	biological_process	late endosome to vacuole transport
S	1990621	cellular_component	ESCRT IV complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ADP A 701

Chain	Residue
A	ASP134
A	GLY336
A	SER337
A	BEF702
A	MG703
B	ASN261
B	ARG288
A	VAL135
A	ALA136
A	GLY176
A	THR177
A	GLY178
A	LYS179
A	SER180
A	TYR181

site_id	AC2
Number of Residues	8
Details	binding site for residue BEF A 702

Chain	Residue
A	PRO174
A	PRO175
A	GLY176
A	LYS179
A	ASN277
A	ADP701
A	MG703
B	ARG288

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 703

Chain	Residue
A	SER180
A	ADP701
A	BEF702

site_id	AC4
Number of Residues	15
Details	binding site for residue ADP B 701

Chain	Residue
B	ASP134
B	ALA136
B	GLY176
B	THR177
B	GLY178
B	LYS179
B	SER180
B	TYR181
B	MET307
B	GLY336
B	SER337
B	BEF702
B	MG703
C	ASN261
C	ARG288

site_id	AC5
Number of Residues	9
Details	binding site for residue BEF B 702

Chain	Residue
B	PRO174
B	PRO175
B	GLY176
B	LYS179
B	SER180
B	ADP701
B	MG703
C	ARG288
C	ARG289

site_id	AC6
Number of Residues	3
Details	binding site for residue MG B 703

Chain	Residue
B	SER180
B	ADP701
B	BEF702

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP C 701

Chain	Residue
C	ASP134
C	VAL135
C	ALA136
C	GLY176
C	THR177
C	GLY178
C	LYS179
C	SER180
C	TYR181
C	BEF702
C	MG703
D	ASN261
D	ARG288

site_id	AC8
Number of Residues	8
Details	binding site for residue BEF C 702

Chain	Residue
C	PRO174
C	GLY176
C	LYS179
C	SER180
C	ADP701
C	MG703
D	ARG288
D	ARG289

site_id	AC9
Number of Residues	3
Details	binding site for residue MG C 703

Chain	Residue
C	SER180
C	ADP701
C	BEF702

site_id	AD1
Number of Residues	10
Details	binding site for residue ADP D 701

Chain	Residue
D	ASP134
D	ALA136
D	GLY176
D	THR177
D	GLY178
D	LYS179
D	SER180
D	TYR181
D	GLY336
D	MG702

site_id	AD2
Number of Residues	2
Details	binding site for residue MG D 702

Chain	Residue
D	SER180
D	ADP701

site_id	AD3
Number of Residues	8
Details	binding site for residue ADP E 701

Chain	Residue
E	PRO175
E	GLY176
E	THR177
E	GLY178
E	LYS179
E	SER180
E	TYR181
E	GLY336

site_id	AD4
Number of Residues	11
Details	binding site for Di-peptide ILE F 354 and GLU F 398

Chain	Residue
F	ILE351
F	ARG352
F	LYS353
F	GLN355
F	SER356
F	LEU396
F	LYS397
F	PRO399
F	ASP400
A	ARG163
F	PRO350

site_id	AD5
Number of Residues	11
Details	binding site for Di-peptide ILE F 354 and GLU F 398

Chain	Residue
A	ARG163
F	PRO350
F	ILE351
F	ARG352
F	LYS353
F	GLN355
F	SER356
F	LEU396
F	LYS397
F	PRO399
F	ASP400

site_id	AD6
Number of Residues	4
Details	binding site for Di-peptide ACE G 0 and ASP G 165

Chain	Residue
A	LYS205
A	TRP206
G	GLU166
G	ILE167

site_id	AD7
Number of Residues	5
Details	binding site for Di-peptide LEU G 172 and NH2 G 173

Chain	Residue
D	SER204
D	LYS205
D	MET207
D	GLU247
G	VAL171

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. VlVLgATNipwqLDsAIrrR

Chain	Residue	Details
A	VAL270-ARG289

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	57
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	480
Details	Region: {"description":"Interaction with VSP4"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)