6AO6
Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0006518 | biological_process | peptide metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016715 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 401 |
| Chain | Residue |
| A | HIS242 |
| A | HIS244 |
| A | MET314 |
| A | HOH513 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | HIS235 |
| A | ASP282 |
| A | HIS305 |
| A | HOH503 |
| A | HOH512 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | THR130 |
| A | CYS131 |
| A | ASP133 |
| A | LYS134 |
| A | ALA135 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ASN136 |
| A | LEU138 |
| A | ARG157 |
| A | GLY163 |
| A | SER164 |
| A | ALA202 |
| A | SER330 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | LEU138 |
| A | TYR139 |
| A | ALA140 |
| A | THR148 |
| A | PHE274 |
| A | MET320 |
Functional Information from PROSITE/UniProt
| site_id | PS00085 |
| Number of Residues | 13 |
| Details | CU2_MONOOXYGENASE_2 Copper type II, ascorbate-dependent monooxygenases signature 2. HvFayrvHTHhlG |
| Chain | Residue | Details |
| A | HIS235-GLY247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16100265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16100265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30271955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30271955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 135 |
| Chain | Residue | Details |
| A | HIS107 | metal ligand |
| A | ALA108 | hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay |
| A | GLN170 | hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay |
| A | HIS172 | metal ligand |
| A | HIS242 | metal ligand |
| A | HIS244 | metal ligand |
| A | MET314 | metal ligand |
