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6ALJ

ALDH1A2 liganded with NAD and compound WIN18,446

Functional Information from GO Data
ChainGOidnamespacecontents
A0001568biological_processblood vessel development
A0001758molecular_functionretinal dehydrogenase activity
A0001822biological_processkidney development
A0001889biological_processliver development
A0002138biological_processretinoic acid biosynthetic process
A0003007biological_processheart morphogenesis
A0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006776biological_processvitamin A metabolic process
A0007494biological_processmidgut development
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009855biological_processdetermination of bilateral symmetry
A0009952biological_processanterior/posterior pattern specification
A0009954biological_processproximal/distal pattern formation
A0010628biological_processpositive regulation of gene expression
A0014032biological_processneural crest cell development
A0016331biological_processmorphogenesis of embryonic epithelium
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0016918molecular_functionretinal binding
A0021915biological_processneural tube development
A0021983biological_processpituitary gland development
A0030182biological_processneuron differentiation
A0030324biological_processlung development
A0030326biological_processembryonic limb morphogenesis
A0030900biological_processforebrain development
A0030902biological_processhindbrain development
A0031016biological_processpancreas development
A0031076biological_processembryonic camera-type eye development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0035115biological_processembryonic forelimb morphogenesis
A0035799biological_processureter maturation
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0042574biological_processretinal metabolic process
A0042904biological_process9-cis-retinoic acid biosynthetic process
A0043010biological_processcamera-type eye development
A0043065biological_processpositive regulation of apoptotic process
A0048384biological_processretinoic acid receptor signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0048566biological_processembryonic digestive tract development
A0048738biological_processcardiac muscle tissue development
A0051289biological_processprotein homotetramerization
A0060324biological_processface development
A0071300biological_processcellular response to retinoic acid
A1905562biological_processregulation of vascular endothelial cell proliferation
B0001568biological_processblood vessel development
B0001758molecular_functionretinal dehydrogenase activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0002138biological_processretinoic acid biosynthetic process
B0003007biological_processheart morphogenesis
B0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006776biological_processvitamin A metabolic process
B0007494biological_processmidgut development
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0009855biological_processdetermination of bilateral symmetry
B0009952biological_processanterior/posterior pattern specification
B0009954biological_processproximal/distal pattern formation
B0010628biological_processpositive regulation of gene expression
B0014032biological_processneural crest cell development
B0016331biological_processmorphogenesis of embryonic epithelium
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0016918molecular_functionretinal binding
B0021915biological_processneural tube development
B0021983biological_processpituitary gland development
B0030182biological_processneuron differentiation
B0030324biological_processlung development
B0030326biological_processembryonic limb morphogenesis
B0030900biological_processforebrain development
B0030902biological_processhindbrain development
B0031016biological_processpancreas development
B0031076biological_processembryonic camera-type eye development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0035115biological_processembryonic forelimb morphogenesis
B0035799biological_processureter maturation
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0042574biological_processretinal metabolic process
B0042904biological_process9-cis-retinoic acid biosynthetic process
B0043010biological_processcamera-type eye development
B0043065biological_processpositive regulation of apoptotic process
B0048384biological_processretinoic acid receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0048566biological_processembryonic digestive tract development
B0048738biological_processcardiac muscle tissue development
B0051289biological_processprotein homotetramerization
B0060324biological_processface development
B0071300biological_processcellular response to retinoic acid
B1905562biological_processregulation of vascular endothelial cell proliferation
C0001568biological_processblood vessel development
C0001758molecular_functionretinal dehydrogenase activity
C0001822biological_processkidney development
C0001889biological_processliver development
C0002138biological_processretinoic acid biosynthetic process
C0003007biological_processheart morphogenesis
C0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006776biological_processvitamin A metabolic process
C0007494biological_processmidgut development
C0008283biological_processcell population proliferation
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0009855biological_processdetermination of bilateral symmetry
C0009952biological_processanterior/posterior pattern specification
C0009954biological_processproximal/distal pattern formation
C0010628biological_processpositive regulation of gene expression
C0014032biological_processneural crest cell development
C0016331biological_processmorphogenesis of embryonic epithelium
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0016918molecular_functionretinal binding
C0021915biological_processneural tube development
C0021983biological_processpituitary gland development
C0030182biological_processneuron differentiation
C0030324biological_processlung development
C0030326biological_processembryonic limb morphogenesis
C0030900biological_processforebrain development
C0030902biological_processhindbrain development
C0031016biological_processpancreas development
C0031076biological_processembryonic camera-type eye development
C0032355biological_processresponse to estradiol
C0032526biological_processresponse to retinoic acid
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0035115biological_processembryonic forelimb morphogenesis
C0035799biological_processureter maturation
C0042572biological_processretinol metabolic process
C0042573biological_processretinoic acid metabolic process
C0042574biological_processretinal metabolic process
C0042904biological_process9-cis-retinoic acid biosynthetic process
C0043010biological_processcamera-type eye development
C0043065biological_processpositive regulation of apoptotic process
C0048384biological_processretinoic acid receptor signaling pathway
C0048471cellular_componentperinuclear region of cytoplasm
C0048566biological_processembryonic digestive tract development
C0048738biological_processcardiac muscle tissue development
C0051289biological_processprotein homotetramerization
C0060324biological_processface development
C0071300biological_processcellular response to retinoic acid
C1905562biological_processregulation of vascular endothelial cell proliferation
D0001568biological_processblood vessel development
D0001758molecular_functionretinal dehydrogenase activity
D0001822biological_processkidney development
D0001889biological_processliver development
D0002138biological_processretinoic acid biosynthetic process
D0003007biological_processheart morphogenesis
D0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006776biological_processvitamin A metabolic process
D0007494biological_processmidgut development
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009855biological_processdetermination of bilateral symmetry
D0009952biological_processanterior/posterior pattern specification
D0009954biological_processproximal/distal pattern formation
D0010628biological_processpositive regulation of gene expression
D0014032biological_processneural crest cell development
D0016331biological_processmorphogenesis of embryonic epithelium
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0016918molecular_functionretinal binding
D0021915biological_processneural tube development
D0021983biological_processpituitary gland development
D0030182biological_processneuron differentiation
D0030324biological_processlung development
D0030326biological_processembryonic limb morphogenesis
D0030900biological_processforebrain development
D0030902biological_processhindbrain development
D0031016biological_processpancreas development
D0031076biological_processembryonic camera-type eye development
D0032355biological_processresponse to estradiol
D0032526biological_processresponse to retinoic acid
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0035115biological_processembryonic forelimb morphogenesis
D0035799biological_processureter maturation
D0042572biological_processretinol metabolic process
D0042573biological_processretinoic acid metabolic process
D0042574biological_processretinal metabolic process
D0042904biological_process9-cis-retinoic acid biosynthetic process
D0043010biological_processcamera-type eye development
D0043065biological_processpositive regulation of apoptotic process
D0048384biological_processretinoic acid receptor signaling pathway
D0048471cellular_componentperinuclear region of cytoplasm
D0048566biological_processembryonic digestive tract development
D0048738biological_processcardiac muscle tissue development
D0051289biological_processprotein homotetramerization
D0060324biological_processface development
D0071300biological_processcellular response to retinoic acid
D1905562biological_processregulation of vascular endothelial cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues26
Detailsbinding site for residue NAD A 601
ChainResidue
AILE183
AGLY247
AALA248
APHE261
AGLY263
ASER264
AVAL267
AGLU286
ALEU287
ALYS366
AGLN367
AILE184
ALYS370
AGLU417
APHE419
ACW2602
AHOH729
AHOH745
AHOH880
APRO185
ATRP186
AASN187
ALYS210
AALA212
AGLU213
AGLY243

site_idAC2
Number of Residues13
Detailsbinding site for residue CW2 A 602
ChainResidue
ATHR146
AASN187
APHE188
ALEU191
AMET192
ATRP195
AGLU286
ACYS319
ACYS320
ALEU477
AASN478
AALA479
ANAD601

site_idAC3
Number of Residues31
Detailsbinding site for residue NAD C 601
ChainResidue
CILE183
CILE184
CPRO185
CTRP186
CASN187
CMET192
CLYS210
CALA212
CGLU213
CGLY243
CGLY247
CALA248
CPHE261
CGLY263
CSER264
CVAL267
CGLU286
CLEU287
CCYS320
CLYS366
CGLN367
CLYS370
CGLU417
CPHE419
CCW2602
CHOH719
CHOH772
CHOH924
CHOH1002
CHOH1003
CHOH1043

site_idAC4
Number of Residues25
Detailsbinding site for residue NAD D 602
ChainResidue
DILE183
DILE184
DPRO185
DTRP186
DASN187
DLYS210
DALA212
DGLU213
DGLY243
DGLY247
DALA248
DPHE261
DGLY263
DSER264
DVAL267
DGLU286
DLEU287
DLYS366
DGLN367
DLYS370
DGLU417
DPHE419
DCW2601
DHOH736
DHOH841

site_idAC5
Number of Residues38
Detailsbinding site for residue NAD B 601
ChainResidue
BASN187
BMET192
BLYS210
BALA212
BGLU213
BGLY243
BGLY247
BALA248
BPHE261
BGLY263
BSER264
BVAL267
BGLU286
BLEU287
BLYS366
BGLN367
BTYR368
BASN369
BILE371
BLEU372
BGLU373
BLEU374
BGLU417
BILE418
BPHE419
BCW2602
BHOH742
BHOH838
BHOH940
BHOH985
BHOH1000
BHOH1014
BHOH1015
BHOH1020
BILE183
BILE184
BPRO185
BTRP186

site_idAC6
Number of Residues19
Detailsbinding site for residue CW2 B 602
ChainResidue
BVAL138
BTHR146
BASN187
BPHE188
BLEU191
BMET192
BTRP195
BCYS319
BTHR321
BALA322
BPHE419
BLEU445
BLEU477
BASN478
BALA479
BNAD601
BHOH741
BHOH749
BHOH1017

site_idAC7
Number of Residues20
Detailsbinding site for residue CW2 C 602
ChainResidue
CGLY142
CTHR146
CASN187
CPHE188
CLEU191
CMET192
CTRP195
CGLU286
CPHE314
CCYS319
CTHR321
CALA322
CPHE419
CLEU445
CLEU477
CASN478
CALA479
CNAD601
CHOH759
CHOH924

site_idAC8
Number of Residues17
Detailsbinding site for residue CW2 D 601
ChainResidue
DGLY142
DTHR146
DASN187
DPHE188
DLEU191
DMET192
DTRP195
DGLU286
DCYS319
DTHR321
DALA322
DPHE419
DLEU445
DASN478
DALA479
DNAD602
DHOH823

Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCTAGS
ChainResidueDetails
APHE313-SER324

site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU285-PRO292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008
ChainResidueDetails
AGLU286
BGLU286
CGLU286
DGLU286

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008, ECO:0000269|PubMed:29240402
ChainResidueDetails
ACYS320
BCYS320
CCYS320
DCYS320

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:29240402, ECO:0007744|PDB:4X2Q, ECO:0007744|PDB:6ALJ, ECO:0007744|PDB:6B5G, ECO:0007744|PDB:6B5H
ChainResidueDetails
AILE184
ALYS210
BILE184
BLYS210
CILE184
CLYS210
DILE184
DLYS210

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:29240402, ECO:0007744|PDB:6ALJ, ECO:0007744|PDB:6B5G, ECO:0007744|PDB:6B5H
ChainResidueDetails
ASER264
DSER264
DLYS366
DGLU417
ALYS366
AGLU417
BSER264
BLYS366
BGLU417
CSER264
CLYS366
CGLU417

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250
ChainResidueDetails
AASN187
BASN187
CASN187
DASN187

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR168
BTYR168
CTYR168
DTYR168

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER351
BSER351
CSER351
DSER351

225946

PDB entries from 2024-10-09

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