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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6ALJ

ALDH1A2 liganded with NAD and compound WIN18,446

Functional Information from GO Data
ChainGOidnamespacecontents
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0001822biological_processkidney development
A0001889biological_processliver development
A0002138biological_processretinoic acid biosynthetic process
A0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006081biological_processaldehyde metabolic process
A0006629biological_processlipid metabolic process
A0006776biological_processvitamin A metabolic process
A0007494biological_processmidgut development
A0008285biological_processnegative regulation of cell population proliferation
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0016918molecular_functionretinal binding
A0021915biological_processneural tube development
A0021983biological_processpituitary gland development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0048471cellular_componentperinuclear region of cytoplasm
A0051289biological_processprotein homotetramerization
A0071300biological_processcellular response to retinoic acid
B0001758molecular_functionretinal dehydrogenase (NAD+) activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0002138biological_processretinoic acid biosynthetic process
B0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006081biological_processaldehyde metabolic process
B0006629biological_processlipid metabolic process
B0006776biological_processvitamin A metabolic process
B0007494biological_processmidgut development
B0008285biological_processnegative regulation of cell population proliferation
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0016918molecular_functionretinal binding
B0021915biological_processneural tube development
B0021983biological_processpituitary gland development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0048471cellular_componentperinuclear region of cytoplasm
B0051289biological_processprotein homotetramerization
B0071300biological_processcellular response to retinoic acid
C0001758molecular_functionretinal dehydrogenase (NAD+) activity
C0001822biological_processkidney development
C0001889biological_processliver development
C0002138biological_processretinoic acid biosynthetic process
C0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006081biological_processaldehyde metabolic process
C0006629biological_processlipid metabolic process
C0006776biological_processvitamin A metabolic process
C0007494biological_processmidgut development
C0008285biological_processnegative regulation of cell population proliferation
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0016918molecular_functionretinal binding
C0021915biological_processneural tube development
C0021983biological_processpituitary gland development
C0032355biological_processresponse to estradiol
C0032526biological_processresponse to retinoic acid
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0042572biological_processretinol metabolic process
C0042573biological_processretinoic acid metabolic process
C0048471cellular_componentperinuclear region of cytoplasm
C0051289biological_processprotein homotetramerization
C0071300biological_processcellular response to retinoic acid
D0001758molecular_functionretinal dehydrogenase (NAD+) activity
D0001822biological_processkidney development
D0001889biological_processliver development
D0002138biological_processretinoic acid biosynthetic process
D0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006081biological_processaldehyde metabolic process
D0006629biological_processlipid metabolic process
D0006776biological_processvitamin A metabolic process
D0007494biological_processmidgut development
D0008285biological_processnegative regulation of cell population proliferation
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0016918molecular_functionretinal binding
D0021915biological_processneural tube development
D0021983biological_processpituitary gland development
D0032355biological_processresponse to estradiol
D0032526biological_processresponse to retinoic acid
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0042572biological_processretinol metabolic process
D0042573biological_processretinoic acid metabolic process
D0048471cellular_componentperinuclear region of cytoplasm
D0051289biological_processprotein homotetramerization
D0071300biological_processcellular response to retinoic acid
Functional Information from PDB Data
site_idAC1
Number of Residues26
Detailsbinding site for residue NAD A 601
ChainResidue
AILE183
AGLY247
AALA248
APHE261
AGLY263
ASER264
AVAL267
AGLU286
ALEU287
ALYS366
AGLN367
AILE184
ALYS370
AGLU417
APHE419
ACW2602
AHOH729
AHOH745
AHOH880
APRO185
ATRP186
AASN187
ALYS210
AALA212
AGLU213
AGLY243
site_idAC2
Number of Residues13
Detailsbinding site for residue CW2 A 602
ChainResidue
ATHR146
AASN187
APHE188
ALEU191
AMET192
ATRP195
AGLU286
ACYS319
ACYS320
ALEU477
AASN478
AALA479
ANAD601
site_idAC3
Number of Residues31
Detailsbinding site for residue NAD C 601
ChainResidue
CILE183
CILE184
CPRO185
CTRP186
CASN187
CMET192
CLYS210
CALA212
CGLU213
CGLY243
CGLY247
CALA248
CPHE261
CGLY263
CSER264
CVAL267
CGLU286
CLEU287
CCYS320
CLYS366
CGLN367
CLYS370
CGLU417
CPHE419
CCW2602
CHOH719
CHOH772
CHOH924
CHOH1002
CHOH1003
CHOH1043
site_idAC4
Number of Residues25
Detailsbinding site for residue NAD D 602
ChainResidue
DILE183
DILE184
DPRO185
DTRP186
DASN187
DLYS210
DALA212
DGLU213
DGLY243
DGLY247
DALA248
DPHE261
DGLY263
DSER264
DVAL267
DGLU286
DLEU287
DLYS366
DGLN367
DLYS370
DGLU417
DPHE419
DCW2601
DHOH736
DHOH841
site_idAC5
Number of Residues38
Detailsbinding site for residue NAD B 601
ChainResidue
BASN187
BMET192
BLYS210
BALA212
BGLU213
BGLY243
BGLY247
BALA248
BPHE261
BGLY263
BSER264
BVAL267
BGLU286
BLEU287
BLYS366
BGLN367
BTYR368
BASN369
BILE371
BLEU372
BGLU373
BLEU374
BGLU417
BILE418
BPHE419
BCW2602
BHOH742
BHOH838
BHOH940
BHOH985
BHOH1000
BHOH1014
BHOH1015
BHOH1020
BILE183
BILE184
BPRO185
BTRP186
site_idAC6
Number of Residues19
Detailsbinding site for residue CW2 B 602
ChainResidue
BVAL138
BTHR146
BASN187
BPHE188
BLEU191
BMET192
BTRP195
BCYS319
BTHR321
BALA322
BPHE419
BLEU445
BLEU477
BASN478
BALA479
BNAD601
BHOH741
BHOH749
BHOH1017
site_idAC7
Number of Residues20
Detailsbinding site for residue CW2 C 602
ChainResidue
CGLY142
CTHR146
CASN187
CPHE188
CLEU191
CMET192
CTRP195
CGLU286
CPHE314
CCYS319
CTHR321
CALA322
CPHE419
CLEU445
CLEU477
CASN478
CALA479
CNAD601
CHOH759
CHOH924
site_idAC8
Number of Residues17
Detailsbinding site for residue CW2 D 601
ChainResidue
DGLY142
DTHR146
DASN187
DPHE188
DLEU191
DMET192
DTRP195
DGLU286
DCYS319
DTHR321
DALA322
DPHE419
DLEU445
DASN478
DALA479
DNAD602
DHOH823
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCTAGS
ChainResidueDetails
APHE313-SER324
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU285-PRO292
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29240402","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29240402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ALJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B5H","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29240402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ALJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B5H","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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