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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ALA

Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) in complex with citrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0005507	molecular_function	copper ion binding
A	0006518	biological_process	peptide metabolic process
A	0016020	cellular_component	membrane
A	0016715	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
C	0003824	molecular_function	catalytic activity
C	0004497	molecular_function	monooxygenase activity
C	0005507	molecular_function	copper ion binding
C	0006518	biological_process	peptide metabolic process
C	0016020	cellular_component	membrane
C	0016715	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CU A 1001

Chain	Residue
A	HIS107
A	HIS242
A	HIS244
A	FLC1002

site_id	AC2
Number of Residues	15
Details	binding site for residue FLC A 1002

Chain	Residue
A	HIS172
A	ARG240
A	HIS242
A	HIS244
A	MET314
A	ASN316
A	TYR318
A	CU1001
A	GOL1006
A	HOH1140
A	TYR79
A	HIS107
A	ALA108
A	LEU110
A	GLN170

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 1003

Chain	Residue
A	TYR205
A	GLN228
A	TYR229
A	LYS230
A	MET231
A	MET332
A	THR333

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 1004

Chain	Residue
A	VAL255
A	ASN257
A	GLY258
A	GLY286

site_id	AC5
Number of Residues	10
Details	binding site for residue GOL A 1005

Chain	Residue
A	ARG143
A	ASN144
A	GLN269
A	LEU270
A	PRO271
C	MET103
C	ARG143
C	ASN144
C	GLN269
C	PRO271

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 1006

Chain	Residue
A	LEU110
A	ASN316
A	TYR318
A	FLC1002
A	HOH1166

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL A 1007

Chain	Residue
A	GLY113
A	ASN136
A	LEU138
A	ARG157
A	SER164
A	ALA202
A	SER330

site_id	AC8
Number of Residues	10
Details	binding site for residue GOL A 1008

Chain	Residue
A	VAL210
A	THR212
A	LYS230
A	MET231
A	TYR232
A	PRO233
A	HIS305
A	ILE306
A	HOH1102
A	HOH1122

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL A 1009

Chain	Residue
A	HOH1111
A	HOH1127

site_id	AD1
Number of Residues	4
Details	binding site for residue CU C 1001

Chain	Residue
C	HIS107
C	HIS242
C	HIS244
C	FLC1002

site_id	AD2
Number of Residues	14
Details	binding site for residue FLC C 1002

Chain	Residue
C	TYR79
C	ALA108
C	LEU110
C	GLN170
C	HIS172
C	ARG240
C	HIS242
C	HIS244
C	GLY307
C	MET314
C	TYR318
C	CU1001
C	GOL1003
C	HOH1109

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL C 1003

Chain	Residue
C	MET208
C	MET314
C	ASN316
C	TYR318
C	FLC1002

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL C 1004

Chain	Residue
C	ARG292
C	PRO340
C	PHE343
C	HOH1107

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL C 1005

Chain	Residue
C	TYR205
C	GLN228
C	LYS230
C	MET231
C	THR333
C	GOL1006

site_id	AD6
Number of Residues	3
Details	binding site for residue GOL C 1006

Chain	Residue
C	GOL1005
C	MET332
C	THR333

site_id	AD7
Number of Residues	3
Details	binding site for residue GOL C 1007

Chain	Residue
C	ARG254
C	VAL281
C	ASP282

site_id	AD8
Number of Residues	8
Details	binding site for residue GOL C 1008

Chain	Residue
C	VAL210
C	THR212
C	VAL213
C	MET231
C	TYR232
C	HIS305
C	ILE306
C	HOH1115

Functional Information from PROSITE/UniProt

site_id	PS00085
Number of Residues	13
Details	CU2_MONOOXYGENASE_2 Copper type II, ascorbate-dependent monooxygenases signature 2. HvFayrvHTHhlG

Chain	Residue	Details
A	HIS235-GLY247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:10504734, ECO:0007744\|PDB:1OPM, ECO:0007744\|PDB:3PHM

Chain	Residue	Details
A	HIS107
C	HIS242
C	HIS244
C	MET314
A	ALA108
A	HIS172
A	HIS242
A	HIS244
A	MET314
C	HIS107
C	ALA108
C	HIS172

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 135

Chain	Residue	Details
A	HIS107	metal ligand
A	ALA108	hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay
A	GLN170	hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay
A	HIS172	metal ligand
A	HIS242	metal ligand
A	HIS244	metal ligand
A	MET314	metal ligand

site_id	MCSA2
Number of Residues	7
Details	M-CSA 135

Chain	Residue	Details
C	HIS107	metal ligand
C	ALA108	hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay
C	GLN170	hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay
C	HIS172	metal ligand
C	HIS242	metal ligand
C	HIS244	metal ligand
C	MET314	metal ligand

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PDB entries from 2024-07-17

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