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6AJU

Rat Xanthine oxidoreductase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000255biological_processallantoin metabolic process
A0001933biological_processnegative regulation of protein phosphorylation
A0001937biological_processnegative regulation of endothelial cell proliferation
A0004854molecular_functionxanthine dehydrogenase activity
A0004855molecular_functionxanthine oxidase activity
A0005506molecular_functioniron ion binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0006147biological_processguanine catabolic process
A0006148biological_processinosine catabolic process
A0006149biological_processdeoxyinosine catabolic process
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006161biological_processdeoxyguanosine catabolic process
A0006196biological_processAMP catabolic process
A0006204biological_processIMP catabolic process
A0007595biological_processlactation
A0009114biological_processhypoxanthine catabolic process
A0009115biological_processxanthine catabolic process
A0010044biological_processresponse to aluminum ion
A0010629biological_processnegative regulation of gene expression
A0016226biological_processiron-sulfur cluster assembly
A0016491molecular_functionoxidoreductase activity
A0016529cellular_componentsarcoplasmic reticulum
A0030856biological_processregulation of epithelial cell differentiation
A0032496biological_processresponse to lipopolysaccharide
A0034465biological_processresponse to carbon monoxide
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043546molecular_functionmolybdopterin cofactor binding
A0043605biological_processamide catabolic process
A0045602biological_processnegative regulation of endothelial cell differentiation
A0046038biological_processGMP catabolic process
A0046055biological_processdGMP catabolic process
A0046059biological_processdAMP catabolic process
A0046872molecular_functionmetal ion binding
A0050421molecular_functionnitrite reductase (NO-forming) activity
A0050660molecular_functionflavin adenine dinucleotide binding
A0051536molecular_functioniron-sulfur cluster binding
A0051537molecular_function2 iron, 2 sulfur cluster binding
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070674molecular_functionhypoxanthine dehydrogenase activity
A0070675molecular_functionhypoxanthine oxidase activity
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071949molecular_functionFAD binding
A0097184biological_processresponse to azide
A1900745biological_processpositive regulation of p38MAPK cascade
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001213biological_processnegative regulation of vasculogenesis
F0000255biological_processallantoin metabolic process
F0001933biological_processnegative regulation of protein phosphorylation
F0001937biological_processnegative regulation of endothelial cell proliferation
F0004854molecular_functionxanthine dehydrogenase activity
F0004855molecular_functionxanthine oxidase activity
F0005506molecular_functioniron ion binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005737cellular_componentcytoplasm
F0005777cellular_componentperoxisome
F0005829cellular_componentcytosol
F0006147biological_processguanine catabolic process
F0006148biological_processinosine catabolic process
F0006149biological_processdeoxyinosine catabolic process
F0006154biological_processadenosine catabolic process
F0006157biological_processdeoxyadenosine catabolic process
F0006161biological_processdeoxyguanosine catabolic process
F0006196biological_processAMP catabolic process
F0006204biological_processIMP catabolic process
F0007595biological_processlactation
F0009114biological_processhypoxanthine catabolic process
F0009115biological_processxanthine catabolic process
F0010044biological_processresponse to aluminum ion
F0010629biological_processnegative regulation of gene expression
F0016226biological_processiron-sulfur cluster assembly
F0016491molecular_functionoxidoreductase activity
F0016529cellular_componentsarcoplasmic reticulum
F0030856biological_processregulation of epithelial cell differentiation
F0032496biological_processresponse to lipopolysaccharide
F0034465biological_processresponse to carbon monoxide
F0042542biological_processresponse to hydrogen peroxide
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043546molecular_functionmolybdopterin cofactor binding
F0043605biological_processamide catabolic process
F0045602biological_processnegative regulation of endothelial cell differentiation
F0046038biological_processGMP catabolic process
F0046055biological_processdGMP catabolic process
F0046059biological_processdAMP catabolic process
F0046872molecular_functionmetal ion binding
F0050421molecular_functionnitrite reductase (NO-forming) activity
F0050660molecular_functionflavin adenine dinucleotide binding
F0051536molecular_functioniron-sulfur cluster binding
F0051537molecular_function2 iron, 2 sulfur cluster binding
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070674molecular_functionhypoxanthine dehydrogenase activity
F0070675molecular_functionhypoxanthine oxidase activity
F0071347biological_processcellular response to interleukin-1
F0071356biological_processcellular response to tumor necrosis factor
F0071949molecular_functionFAD binding
F0097184biological_processresponse to azide
F1900745biological_processpositive regulation of p38MAPK cascade
F1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
F2000379biological_processpositive regulation of reactive oxygen species metabolic process
F2001213biological_processnegative regulation of vasculogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue FES A 3001
ChainResidue
AGLN111
ACYS112
AGLY113
ACYS115
ACYS147
AARG148
ACYS149
ALEU744

site_idAC2
Number of Residues10
Detailsbinding site for residue FES A 3002
ChainResidue
ACYS43
AGLY44
AGLY46
AGLY47
ACYS48
AGLY49
ACYS51
AASN71
ACYS73
AGLY42

site_idAC3
Number of Residues13
Detailsbinding site for residue URC A 3003
ChainResidue
AGLU802
AARG880
APHE914
ASER1008
APHE1009
ATHR1010
AALA1078
AALA1079
AGLU1261
AHOH3103
AHOH3247
AHOH3285
AHOH3318

site_idAC4
Number of Residues9
Detailsbinding site for residue BCT A 3004
ChainResidue
AARG839
AHIS840
AILE877
ATHR909
AALA910
APHE911
APHE914
AGLY915
AGLN918

site_idAC5
Number of Residues32
Detailsbinding site for residue FAD A 3005
ChainResidue
AGLU45
AGLY46
ALYS255
ALEU256
AVAL257
AVAL258
AGLY259
AASN260
ATHR261
AGLU262
AILE263
AALA300
APHE336
AALA337
ASER346
AGLY349
AASN350
AILE352
ATHR353
ASER358
AASP359
AILE402
ALEU403
ALYS421
AASP428
AASP429
AHOH3201
AHOH3252
AHOH3332
AHOH3443
AHOH3623
AHOH3668

site_idAC6
Number of Residues7
Detailsbinding site for residue FES F 3001
ChainResidue
FGLN111
FCYS112
FGLY113
FCYS115
FCYS147
FARG148
FCYS149

site_idAC7
Number of Residues10
Detailsbinding site for residue FES F 3002
ChainResidue
FGLY42
FCYS43
FGLY44
FGLY46
FGLY47
FCYS48
FGLY49
FCYS51
FASN71
FCYS73

site_idAC8
Number of Residues13
Detailsbinding site for residue URC F 3003
ChainResidue
FHOH3185
FHOH3319
FHOH3433
FGLU802
FARG880
FPHE914
FSER1008
FPHE1009
FTHR1010
FALA1078
FALA1079
FGLU1261
FHOH3111

site_idAC9
Number of Residues9
Detailsbinding site for residue BCT F 3004
ChainResidue
FARG839
FHIS840
FILE877
FTHR909
FALA910
FPHE911
FPHE914
FGLY915
FGLN918

site_idAD1
Number of Residues30
Detailsbinding site for residue FAD F 3005
ChainResidue
FGLU45
FGLY46
FLYS255
FLEU256
FVAL257
FVAL258
FGLY259
FASN260
FTHR261
FGLU262
FILE263
FALA300
FPHE336
FALA337
FALA345
FSER346
FGLY349
FASN350
FILE352
FTHR353
FSER358
FASP359
FLEU403
FLYS421
FASP428
FASP429
FHOH3313
FHOH3416
FHOH3585
FHOH3611

Functional Information from PROSITE/UniProt
site_idPS00197
Number of Residues9
Details2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CGEGGCGAC
ChainResidueDetails
ACYS43-CYS51

site_idPS00559
Number of Residues36
DetailsMOLYBDOPTERIN_EUK Eukaryotic molybdopterin oxidoreductases signature. GFggKetrstvvstala..LaahKTgrpVrCmlDRdeD
ChainResidueDetails
AGLY797-ASP832

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AGLU1261
FGLU1261

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:17301076, ECO:0007744|PDB:2E3T
ChainResidueDetails
ACYS43
FCYS48
FCYS51
FCYS73
FCYS112
FCYS115
FCYS147
FCYS149
ACYS48
ACYS51
ACYS73
ACYS112
ACYS115
ACYS147
ACYS149
FCYS43

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:15878860, ECO:0000269|PubMed:17301076
ChainResidueDetails
ALEU256
ASER346
AASP359
ALEU403
FLEU256
FSER346
FASP359
FLEU403

site_idSWS_FT_FI4
Number of Residues14
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
APHE336
FGLN767
FPHE798
FARG912
FPHE914
FALA1079
ALYS421
AGLN767
APHE798
AARG912
APHE914
AALA1079
FPHE336
FLYS421

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AGLU802
AARG880
ATHR1010
FGLU802
FARG880
FTHR1010

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PDB entries from 2024-07-24

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