6AJ6

Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
A	0005739	cellular_component	mitochondrion
A	0006099	biological_process	tricarboxylic acid cycle
A	0006102	biological_process	isocitrate metabolic process
A	0006739	biological_process	NADP metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0020015	cellular_component	glycosome
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
C	0005739	cellular_component	mitochondrion
C	0006099	biological_process	tricarboxylic acid cycle
C	0006102	biological_process	isocitrate metabolic process
C	0006739	biological_process	NADP metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0020015	cellular_component	glycosome
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue NAP A 501

site_id	AC2
Number of Residues	15
Details	binding site for residue NAP C 501

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDslAqgf.GSLGM

Chain	Residue	Details
A	ASN270-MET289