Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AHU

Cryo-EM structure of human Ribonuclease P with mature tRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000172	cellular_component	ribonuclease MRP complex
B	0001682	biological_process	tRNA 5'-leader removal
B	0003723	molecular_function	RNA binding
B	0004526	molecular_function	ribonuclease P activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005655	cellular_component	nucleolar ribonuclease P complex
B	0005730	cellular_component	nucleolus
B	0006396	biological_process	RNA processing
B	0008033	biological_process	tRNA processing
B	0016078	biological_process	tRNA decay
B	0030681	cellular_component	multimeric ribonuclease P complex
B	0033204	molecular_function	ribonuclease P RNA binding
C	0000172	cellular_component	ribonuclease MRP complex
C	0001650	cellular_component	fibrillar center
C	0001682	biological_process	tRNA 5'-leader removal
C	0003723	molecular_function	RNA binding
C	0004526	molecular_function	ribonuclease P activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005655	cellular_component	nucleolar ribonuclease P complex
C	0005730	cellular_component	nucleolus
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0008033	biological_process	tRNA processing
C	0030681	cellular_component	multimeric ribonuclease P complex
C	0033204	molecular_function	ribonuclease P RNA binding
D	0000172	cellular_component	ribonuclease MRP complex
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0004526	molecular_function	ribonuclease P activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0008033	biological_process	tRNA processing
D	0030677	cellular_component	ribonuclease P complex
D	0030681	cellular_component	multimeric ribonuclease P complex
D	0033204	molecular_function	ribonuclease P RNA binding
E	0000172	cellular_component	ribonuclease MRP complex
E	0001682	biological_process	tRNA 5'-leader removal
E	0003723	molecular_function	RNA binding
E	0004526	molecular_function	ribonuclease P activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005655	cellular_component	nucleolar ribonuclease P complex
E	0005730	cellular_component	nucleolus
E	0006364	biological_process	rRNA processing
E	0006396	biological_process	RNA processing
E	0008033	biological_process	tRNA processing
E	0030677	cellular_component	ribonuclease P complex
E	0030681	cellular_component	multimeric ribonuclease P complex
E	0033204	molecular_function	ribonuclease P RNA binding
F	0000172	cellular_component	ribonuclease MRP complex
F	0001682	biological_process	tRNA 5'-leader removal
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0004526	molecular_function	ribonuclease P activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0006364	biological_process	rRNA processing
F	0006396	biological_process	RNA processing
F	0008033	biological_process	tRNA processing
F	0030681	cellular_component	multimeric ribonuclease P complex
F	0033204	molecular_function	ribonuclease P RNA binding
G	0000172	cellular_component	ribonuclease MRP complex
G	0001682	biological_process	tRNA 5'-leader removal
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0004526	molecular_function	ribonuclease P activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005655	cellular_component	nucleolar ribonuclease P complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0008033	biological_process	tRNA processing
G	0030681	cellular_component	multimeric ribonuclease P complex
G	0033204	molecular_function	ribonuclease P RNA binding
H	0001682	biological_process	tRNA 5'-leader removal
H	0003723	molecular_function	RNA binding
H	0004526	molecular_function	ribonuclease P activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0006396	biological_process	RNA processing
H	0008033	biological_process	tRNA processing
H	0030677	cellular_component	ribonuclease P complex
H	0030681	cellular_component	multimeric ribonuclease P complex
H	0033204	molecular_function	ribonuclease P RNA binding
H	1902555	cellular_component	endoribonuclease complex
H	1990904	cellular_component	ribonucleoprotein complex
I	0000172	cellular_component	ribonuclease MRP complex
I	0001682	biological_process	tRNA 5'-leader removal
I	0003723	molecular_function	RNA binding
I	0004526	molecular_function	ribonuclease P activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005655	cellular_component	nucleolar ribonuclease P complex
I	0005730	cellular_component	nucleolus
I	0006364	biological_process	rRNA processing
I	0006396	biological_process	RNA processing
I	0008033	biological_process	tRNA processing
I	0030681	cellular_component	multimeric ribonuclease P complex
I	0033204	molecular_function	ribonuclease P RNA binding
J	0000172	cellular_component	ribonuclease MRP complex
J	0001682	biological_process	tRNA 5'-leader removal
J	0003723	molecular_function	RNA binding
J	0004526	molecular_function	ribonuclease P activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005655	cellular_component	nucleolar ribonuclease P complex
J	0005730	cellular_component	nucleolus
J	0006364	biological_process	rRNA processing
J	0006396	biological_process	RNA processing
J	0008033	biological_process	tRNA processing
J	0030681	cellular_component	multimeric ribonuclease P complex
J	0033204	molecular_function	ribonuclease P RNA binding
K	0001682	biological_process	tRNA 5'-leader removal
K	0003723	molecular_function	RNA binding
K	0004526	molecular_function	ribonuclease P activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005655	cellular_component	nucleolar ribonuclease P complex
K	0005730	cellular_component	nucleolus
K	0006396	biological_process	RNA processing
K	0008033	biological_process	tRNA processing
K	0009410	biological_process	response to xenobiotic stimulus
K	0030681	cellular_component	multimeric ribonuclease P complex
K	0033204	molecular_function	ribonuclease P RNA binding
K	0046872	molecular_function	metal ion binding
K	1902555	cellular_component	endoribonuclease complex
K	1990904	cellular_component	ribonucleoprotein complex
L	0000171	molecular_function	ribonuclease MRP activity
L	0000172	cellular_component	ribonuclease MRP complex
L	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L	0001682	biological_process	tRNA 5'-leader removal
L	0003723	molecular_function	RNA binding
L	0004526	molecular_function	ribonuclease P activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005655	cellular_component	nucleolar ribonuclease P complex
L	0005730	cellular_component	nucleolus
L	0006364	biological_process	rRNA processing
L	0006396	biological_process	RNA processing
L	0008033	biological_process	tRNA processing
L	0030677	cellular_component	ribonuclease P complex
L	0030681	cellular_component	multimeric ribonuclease P complex
L	0033204	molecular_function	ribonuclease P RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN K 201

Chain	Residue
K	CYS92
K	THR94
K	CYS95

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"25489052","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lao L.","Ryan K.M."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)