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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6AHC

Cryo-EM structure of aldehyde-alcohol dehydrogenase reveals a high-order helical architecture critical for its activity

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006066biological_processalcohol metabolic process
A0006115biological_processethanol biosynthetic process
A0006979biological_processresponse to oxidative stress
A0008198molecular_functionferrous iron binding
A0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
A0015976biological_processcarbon utilization
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0019664biological_processmixed acid fermentation
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0120542molecular_functionethanol dehydrogenase (NAD+) activity
B0003824molecular_functioncatalytic activity
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006066biological_processalcohol metabolic process
B0006115biological_processethanol biosynthetic process
B0006979biological_processresponse to oxidative stress
B0008198molecular_functionferrous iron binding
B0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
B0015976biological_processcarbon utilization
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0019664biological_processmixed acid fermentation
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0120542molecular_functionethanol dehydrogenase (NAD+) activity
C0003824molecular_functioncatalytic activity
C0004022molecular_functionalcohol dehydrogenase (NAD+) activity
C0005515molecular_functionprotein binding
C0005829cellular_componentcytosol
C0006066biological_processalcohol metabolic process
C0006115biological_processethanol biosynthetic process
C0006979biological_processresponse to oxidative stress
C0008198molecular_functionferrous iron binding
C0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
C0015976biological_processcarbon utilization
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0019664biological_processmixed acid fermentation
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0120542molecular_functionethanol dehydrogenase (NAD+) activity
D0003824molecular_functioncatalytic activity
D0004022molecular_functionalcohol dehydrogenase (NAD+) activity
D0005515molecular_functionprotein binding
D0005829cellular_componentcytosol
D0006066biological_processalcohol metabolic process
D0006115biological_processethanol biosynthetic process
D0006979biological_processresponse to oxidative stress
D0008198molecular_functionferrous iron binding
D0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
D0015976biological_processcarbon utilization
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0019664biological_processmixed acid fermentation
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0120542molecular_functionethanol dehydrogenase (NAD+) activity
E0003824molecular_functioncatalytic activity
E0004022molecular_functionalcohol dehydrogenase (NAD+) activity
E0005515molecular_functionprotein binding
E0005829cellular_componentcytosol
E0006066biological_processalcohol metabolic process
E0006115biological_processethanol biosynthetic process
E0006979biological_processresponse to oxidative stress
E0008198molecular_functionferrous iron binding
E0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
E0015976biological_processcarbon utilization
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E0019664biological_processmixed acid fermentation
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0051260biological_processprotein homooligomerization
E0120542molecular_functionethanol dehydrogenase (NAD+) activity
F0003824molecular_functioncatalytic activity
F0004022molecular_functionalcohol dehydrogenase (NAD+) activity
F0005515molecular_functionprotein binding
F0005829cellular_componentcytosol
F0006066biological_processalcohol metabolic process
F0006115biological_processethanol biosynthetic process
F0006979biological_processresponse to oxidative stress
F0008198molecular_functionferrous iron binding
F0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
F0015976biological_processcarbon utilization
F0016020cellular_componentmembrane
F0016491molecular_functionoxidoreductase activity
F0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F0019664biological_processmixed acid fermentation
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
F0051260biological_processprotein homooligomerization
F0120542molecular_functionethanol dehydrogenase (NAD+) activity
G0003824molecular_functioncatalytic activity
G0004022molecular_functionalcohol dehydrogenase (NAD+) activity
G0005515molecular_functionprotein binding
G0005829cellular_componentcytosol
G0006066biological_processalcohol metabolic process
G0006115biological_processethanol biosynthetic process
G0006979biological_processresponse to oxidative stress
G0008198molecular_functionferrous iron binding
G0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
G0015976biological_processcarbon utilization
G0016020cellular_componentmembrane
G0016491molecular_functionoxidoreductase activity
G0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G0019664biological_processmixed acid fermentation
G0042802molecular_functionidentical protein binding
G0046872molecular_functionmetal ion binding
G0051260biological_processprotein homooligomerization
G0120542molecular_functionethanol dehydrogenase (NAD+) activity
H0003824molecular_functioncatalytic activity
H0004022molecular_functionalcohol dehydrogenase (NAD+) activity
H0005515molecular_functionprotein binding
H0005829cellular_componentcytosol
H0006066biological_processalcohol metabolic process
H0006115biological_processethanol biosynthetic process
H0006979biological_processresponse to oxidative stress
H0008198molecular_functionferrous iron binding
H0008774molecular_functionacetaldehyde dehydrogenase (acetylating) activity
H0015976biological_processcarbon utilization
H0016020cellular_componentmembrane
H0016491molecular_functionoxidoreductase activity
H0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H0019664biological_processmixed acid fermentation
H0042802molecular_functionidentical protein binding
H0046872molecular_functionmetal ion binding
H0051260biological_processprotein homooligomerization
H0120542molecular_functionethanol dehydrogenase (NAD+) activity
Functional Information from PROSITE/UniProt
site_idPS00060
Number of Residues21
DetailsADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. GvCHsmAHkLGSqfhIpHGlA
ChainResidueDetails
AGLY720-ALA740
site_idPS00913
Number of Residues29
DetailsADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AIvDanlvmdmPkslcAfGglDAVthamE
ChainResidueDetails
AALA632-GLU660
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues118
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32523125","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7BVP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32188856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32523125","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6TQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2628
DetailsRegion: {"description":"Aldehyde dehydrogenase","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues42
DetailsRegion: {"description":"Linker","evidences":[{"source":"PubMed","id":"31586059","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"Q9HTJ1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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