6AGT
Crystal structure of PfKRS complexed with chromone inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 9X0 A 601 |
| Chain | Residue |
| A | GLU332 |
| A | ILE570 |
| A | LYS607 |
| A | HOH764 |
| A | HOH765 |
| A | THR337 |
| A | HIS338 |
| A | ASN339 |
| A | PHE342 |
| A | GLU500 |
| A | GLY554 |
| A | GLY556 |
| A | ARG559 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CO A 602 |
| Chain | Residue |
| A | HOH777 |
| A | HOH828 |
| A | HOH830 |
| A | HOH837 |
| A | HOH846 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 603 |
| Chain | Residue |
| A | ARG262 |
| A | ILE325 |
| B | ARG262 |
| B | GLU272 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 604 |
| Chain | Residue |
| A | ARG268 |
| A | HOH772 |
| D | ASP298 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 605 |
| Chain | Residue |
| A | ARG262 |
| A | GLU272 |
| B | ARG262 |
| B | ILE325 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue MLA A 606 |
| Chain | Residue |
| A | LYS321 |
| A | TRP349 |
| A | ALA350 |
| A | TYR351 |
| A | ALA352 |
| A | HOH701 |
| B | LYS105 |
| B | GLU107 |
| B | HOH727 |
| B | HOH810 |
| B | HOH819 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue LYS A 607 |
| Chain | Residue |
| A | GLY284 |
| A | GLU308 |
| A | ARG330 |
| A | GLU346 |
| A | TYR348 |
| A | ASN503 |
| A | TYR505 |
| A | GLU507 |
| A | GLY552 |
| A | GLY554 |
| A | 9X0601 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue 9X0 B 601 |
| Chain | Residue |
| B | GLU332 |
| B | THR337 |
| B | HIS338 |
| B | ASN339 |
| B | PHE342 |
| B | GLY554 |
| B | GLY556 |
| B | ARG559 |
| B | ILE570 |
| B | LYS603 |
| B | HOH778 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CO B 602 |
| Chain | Residue |
| B | HOH703 |
| B | HOH730 |
| B | HOH854 |
| B | HOH867 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue LYS B 603 |
| Chain | Residue |
| B | GLY284 |
| B | GLU308 |
| B | ARG330 |
| B | GLU346 |
| B | TYR348 |
| B | ASN503 |
| B | TYR505 |
| B | GLU507 |
| B | GLY552 |
| B | GLY554 |
| B | 9X0601 |
| B | HOH725 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for residue 9X0 C 601 |
| Chain | Residue |
| C | GLU332 |
| C | THR337 |
| C | HIS338 |
| C | ASN339 |
| C | PHE342 |
| C | GLU500 |
| C | GLY554 |
| C | LEU555 |
| C | GLY556 |
| C | ARG559 |
| C | ILE570 |
| C | LYS606 |
| C | HOH719 |
| C | HOH777 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CO C 602 |
| Chain | Residue |
| C | ASN583 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CO C 603 |
| Chain | Residue |
| C | HOH712 |
| C | HOH754 |
| C | HOH780 |
| C | HOH801 |
| C | HOH813 |
| C | HOH826 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 604 |
| Chain | Residue |
| C | ILE258 |
| C | ARG262 |
| C | ILE325 |
| D | ARG262 |
| D | GLU272 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 605 |
| Chain | Residue |
| C | ARG262 |
| C | GLU272 |
| D | ARG262 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue LYS C 606 |
| Chain | Residue |
| C | GLY284 |
| C | GLU308 |
| C | ARG330 |
| C | GLU346 |
| C | TYR348 |
| C | ASN503 |
| C | TYR505 |
| C | GLU507 |
| C | GLY552 |
| C | 9X0601 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue 9X0 D 601 |
| Chain | Residue |
| D | THR337 |
| D | HIS338 |
| D | ASN339 |
| D | PHE342 |
| D | GLU500 |
| D | GLY554 |
| D | GLY556 |
| D | ARG559 |
| D | ILE570 |
| D | HOH715 |
| D | HOH762 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue CO D 602 |
| Chain | Residue |
| D | HOH729 |
| D | HOH797 |
| D | HOH800 |
| D | HOH801 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MLA D 603 |
| Chain | Residue |
| C | LYS105 |
| C | GLU107 |
| C | ARG108 |
| D | TRP349 |
| D | ALA350 |
| D | TYR351 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue LYS D 604 |
| Chain | Residue |
| D | GLY284 |
| D | GLU308 |
| D | ARG330 |
| D | GLU346 |
| D | TYR348 |
| D | ASN503 |
| D | TYR505 |
| D | GLU507 |
| D | GLY552 |
| D | GLY554 |
