6ACJ
Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0055036 | cellular_component | virion membrane |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| C | 0016020 | cellular_component | membrane |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| D | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| D | GLU375 | |
| B | SER14-PRO1195 | |
| C | SER14-PRO1195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS505 | |
| A | ARG797 | |
| B | ARG667 | |
| B | ARG797 | |
| C | ARG667 | |
| C | ARG797 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| D | ARG169 | |
| A | ASN318 | |
| A | ASN330 | |
| A | ASN357 | |
| A | ASN589 | |
| A | ASN602 | |
| A | ASN691 | |
| A | ASN699 | |
| A | ASN783 | |
| A | ASN1056 | |
| A | ASN1080 | |
| D | TRP477 | |
| A | ASN1116 | |
| A | ASN1140 | |
| A | ASN1155 | |
| A | ASN1176 | |
| B | ASN29 | |
| B | ASN65 | |
| B | ASN73 | |
| B | ASN109 | |
| B | ASN118 | |
| B | ASN119 | |
| D | LYS481 | |
| B | ASN158 | |
| B | ASN227 | |
| B | ASN269 | |
| B | ASN318 | |
| B | ASN330 | |
| B | ASN357 | |
| B | ASN589 | |
| B | ASN602 | |
| B | ASN691 | |
| B | ASN699 | |
| A | ASN109 | |
| B | ASN783 | |
| B | ASN1056 | |
| B | ASN1080 | |
| B | ASN1116 | |
| B | ASN1140 | |
| B | ASN1155 | |
| B | ASN1176 | |
| C | ASN29 | |
| C | ASN65 | |
| C | ASN73 | |
| A | ASN118 | |
| C | ASN109 | |
| C | ASN118 | |
| C | ASN119 | |
| C | ASN158 | |
| C | ASN227 | |
| C | ASN269 | |
| C | ASN318 | |
| C | ASN330 | |
| C | ASN357 | |
| C | ASN589 | |
| A | ASN119 | |
| C | ASN602 | |
| C | ASN691 | |
| C | ASN699 | |
| C | ASN783 | |
| C | ASN1056 | |
| C | ASN1080 | |
| C | ASN1116 | |
| C | ASN1140 | |
| C | ASN1155 | |
| C | ASN1176 | |
| A | ASN158 | |
| A | ASN227 | |
| A | ASN269 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | ARG273 | |
| D | HIS345 | |
| D | TYR515 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS374 | |
| D | HIS378 | |
| D | GLU402 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN53 | |
| D | ASN322 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN90 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN103 | |
| D | ASN432 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN546 |
