6ACH

Structure of NAD+-bound leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0006520	biological_process	amino acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0006520	biological_process	amino acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
D	0006520	biological_process	amino acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
E	0006520	biological_process	amino acid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
F	0006520	biological_process	amino acid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
G	0006520	biological_process	amino acid metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
H	0006520	biological_process	amino acid metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue NAD A 400

Chain	Residue
A	SER147
A	LEU239
A	SER259
A	ASN261
A	THR150
A	GLY180
A	GLY182
A	VAL184
A	ASP203
A	ILE204
A	CYS237
A	ALA238

---

site_id	AC2
Number of Residues	12
Details	binding site for residue NAD B 400

Chain	Residue
B	SER147
B	THR150
B	GLY180
B	GLY182
B	VAL184
B	ASP203
B	ILE204
B	CYS237
B	ALA238
B	LEU239
B	SER259
B	ASN261

---

site_id	AC3
Number of Residues	12
Details	binding site for residue NAD C 400

Chain	Residue
C	SER147
C	THR150
C	GLY180
C	GLY182
C	VAL184
C	ASP203
C	ILE204
C	CYS237
C	ALA238
C	LEU239
C	SER259
C	ASN261

---

site_id	AC4
Number of Residues	12
Details	binding site for residue NAD D 400

Chain	Residue
D	SER147
D	THR150
D	GLY180
D	GLY182
D	VAL184
D	ASP203
D	ILE204
D	CYS237
D	ALA238
D	LEU239
D	SER259
D	ASN261

---

site_id	AC5
Number of Residues	12
Details	binding site for residue NAD E 400

Chain	Residue
E	SER147
E	THR150
E	GLY180
E	GLY182
E	VAL184
E	ASP203
E	ILE204
E	CYS237
E	ALA238
E	LEU239
E	SER259
E	ASN261

---

site_id	AC6
Number of Residues	12
Details	binding site for residue NAD F 400

Chain	Residue
F	SER147
F	THR150
F	GLY180
F	GLY182
F	VAL184
F	ASP203
F	ILE204
F	CYS237
F	ALA238
F	LEU239
F	SER259
F	ASN261

---

site_id	AC7
Number of Residues	12
Details	binding site for residue NAD G 400

Chain	Residue
G	SER147
G	THR150
G	GLY180
G	GLY182
G	VAL184
G	ASP203
G	ILE204
G	CYS237
G	ALA238
G	LEU239
G	SER259
G	ASN261

---

site_id	AC8
Number of Residues	12
Details	binding site for residue NAD H 400

Chain	Residue
H	SER147
H	THR150
H	GLY180
H	GLY182
H	VAL184
H	ASP203
H	ILE204
H	CYS237
H	ALA238
H	LEU239
H	SER259
H	ASN261

---

Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnlGGGKtViigDP

Chain	Residue	Details
A	LEU74-PRO87

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