6ACH
Structure of NAD+-bound leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| G | 0006520 | biological_process | amino acid metabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| H | 0006520 | biological_process | amino acid metabolic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue NAD A 400 |
| Chain | Residue |
| A | SER147 |
| A | LEU239 |
| A | SER259 |
| A | ASN261 |
| A | THR150 |
| A | GLY180 |
| A | GLY182 |
| A | VAL184 |
| A | ASP203 |
| A | ILE204 |
| A | CYS237 |
| A | ALA238 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue NAD B 400 |
| Chain | Residue |
| B | SER147 |
| B | THR150 |
| B | GLY180 |
| B | GLY182 |
| B | VAL184 |
| B | ASP203 |
| B | ILE204 |
| B | CYS237 |
| B | ALA238 |
| B | LEU239 |
| B | SER259 |
| B | ASN261 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue NAD C 400 |
| Chain | Residue |
| C | SER147 |
| C | THR150 |
| C | GLY180 |
| C | GLY182 |
| C | VAL184 |
| C | ASP203 |
| C | ILE204 |
| C | CYS237 |
| C | ALA238 |
| C | LEU239 |
| C | SER259 |
| C | ASN261 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue NAD D 400 |
| Chain | Residue |
| D | SER147 |
| D | THR150 |
| D | GLY180 |
| D | GLY182 |
| D | VAL184 |
| D | ASP203 |
| D | ILE204 |
| D | CYS237 |
| D | ALA238 |
| D | LEU239 |
| D | SER259 |
| D | ASN261 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue NAD E 400 |
| Chain | Residue |
| E | SER147 |
| E | THR150 |
| E | GLY180 |
| E | GLY182 |
| E | VAL184 |
| E | ASP203 |
| E | ILE204 |
| E | CYS237 |
| E | ALA238 |
| E | LEU239 |
| E | SER259 |
| E | ASN261 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue NAD F 400 |
| Chain | Residue |
| F | SER147 |
| F | THR150 |
| F | GLY180 |
| F | GLY182 |
| F | VAL184 |
| F | ASP203 |
| F | ILE204 |
| F | CYS237 |
| F | ALA238 |
| F | LEU239 |
| F | SER259 |
| F | ASN261 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue NAD G 400 |
| Chain | Residue |
| G | SER147 |
| G | THR150 |
| G | GLY180 |
| G | GLY182 |
| G | VAL184 |
| G | ASP203 |
| G | ILE204 |
| G | CYS237 |
| G | ALA238 |
| G | LEU239 |
| G | SER259 |
| G | ASN261 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue NAD H 400 |
| Chain | Residue |
| H | SER147 |
| H | THR150 |
| H | GLY180 |
| H | GLY182 |
| H | VAL184 |
| H | ASP203 |
| H | ILE204 |
| H | CYS237 |
| H | ALA238 |
| H | LEU239 |
| H | SER259 |
| H | ASN261 |
Functional Information from PROSITE/UniProt
| site_id | PS00074 |
| Number of Residues | 14 |
| Details | GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnlGGGKtViigDP |
| Chain | Residue | Details |
| A | LEU74-PRO87 |
