6ACH
Structure of NAD+-bound leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
D | 0006520 | biological_process | amino acid metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
E | 0006520 | biological_process | amino acid metabolic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
F | 0006520 | biological_process | amino acid metabolic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
G | 0006520 | biological_process | amino acid metabolic process |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
H | 0006520 | biological_process | amino acid metabolic process |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue NAD A 400 |
Chain | Residue |
A | SER147 |
A | LEU239 |
A | SER259 |
A | ASN261 |
A | THR150 |
A | GLY180 |
A | GLY182 |
A | VAL184 |
A | ASP203 |
A | ILE204 |
A | CYS237 |
A | ALA238 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue NAD B 400 |
Chain | Residue |
B | SER147 |
B | THR150 |
B | GLY180 |
B | GLY182 |
B | VAL184 |
B | ASP203 |
B | ILE204 |
B | CYS237 |
B | ALA238 |
B | LEU239 |
B | SER259 |
B | ASN261 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue NAD C 400 |
Chain | Residue |
C | SER147 |
C | THR150 |
C | GLY180 |
C | GLY182 |
C | VAL184 |
C | ASP203 |
C | ILE204 |
C | CYS237 |
C | ALA238 |
C | LEU239 |
C | SER259 |
C | ASN261 |
site_id | AC4 |
Number of Residues | 12 |
Details | binding site for residue NAD D 400 |
Chain | Residue |
D | SER147 |
D | THR150 |
D | GLY180 |
D | GLY182 |
D | VAL184 |
D | ASP203 |
D | ILE204 |
D | CYS237 |
D | ALA238 |
D | LEU239 |
D | SER259 |
D | ASN261 |
site_id | AC5 |
Number of Residues | 12 |
Details | binding site for residue NAD E 400 |
Chain | Residue |
E | SER147 |
E | THR150 |
E | GLY180 |
E | GLY182 |
E | VAL184 |
E | ASP203 |
E | ILE204 |
E | CYS237 |
E | ALA238 |
E | LEU239 |
E | SER259 |
E | ASN261 |
site_id | AC6 |
Number of Residues | 12 |
Details | binding site for residue NAD F 400 |
Chain | Residue |
F | SER147 |
F | THR150 |
F | GLY180 |
F | GLY182 |
F | VAL184 |
F | ASP203 |
F | ILE204 |
F | CYS237 |
F | ALA238 |
F | LEU239 |
F | SER259 |
F | ASN261 |
site_id | AC7 |
Number of Residues | 12 |
Details | binding site for residue NAD G 400 |
Chain | Residue |
G | SER147 |
G | THR150 |
G | GLY180 |
G | GLY182 |
G | VAL184 |
G | ASP203 |
G | ILE204 |
G | CYS237 |
G | ALA238 |
G | LEU239 |
G | SER259 |
G | ASN261 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residue NAD H 400 |
Chain | Residue |
H | SER147 |
H | THR150 |
H | GLY180 |
H | GLY182 |
H | VAL184 |
H | ASP203 |
H | ILE204 |
H | CYS237 |
H | ALA238 |
H | LEU239 |
H | SER259 |
H | ASN261 |
Functional Information from PROSITE/UniProt
site_id | PS00074 |
Number of Residues | 14 |
Details | GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnlGGGKtViigDP |
Chain | Residue | Details |
A | LEU74-PRO87 |