6AAX

Crystal structure of TFB1M and h45 with SAM in homo sapiens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000154	biological_process	rRNA modification
A	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006364	biological_process	rRNA processing
A	0006391	biological_process	transcription initiation at mitochondrial promoter
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0034246	molecular_function	mitochondrial transcription factor activity
A	0042645	cellular_component	mitochondrial nucleoid
A	0180026	biological_process	mitochondrial small ribosomal subunit assembly
A	1904047	molecular_function	S-adenosyl-L-methionine binding
C	0000154	biological_process	rRNA modification
C	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006364	biological_process	rRNA processing
C	0006391	biological_process	transcription initiation at mitochondrial promoter
C	0008168	molecular_function	methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0031167	biological_process	rRNA methylation
C	0032259	biological_process	methylation
C	0034246	molecular_function	mitochondrial transcription factor activity
C	0042645	cellular_component	mitochondrial nucleoid
C	0180026	biological_process	mitochondrial small ribosomal subunit assembly
C	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SAM A 401

Chain	Residue
A	ASN36
A	GLY110
A	ASP111
A	VAL112
A	ASN141
A	LEU142
A	PRO143
A	VAL146
A	PHE37
A	LEU38
A	GLY63
A	PRO64
A	GLY65
A	GLU85
A	LYS86
A	PHE90

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site_id	AC2
Number of Residues	4
Details	binding site for residue PEG A 402

Chain	Residue
A	PRO66
A	ARG71
A	GLY93
C	LEU39

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site_id	AC3
Number of Residues	17
Details	binding site for residue SAM C 401

Chain	Residue
C	ASN36
C	PHE37
C	LEU38
C	GLY63
C	PRO64
C	PRO66
C	GLY68
C	ILE69
C	GLU85
C	LYS86
C	PHE90
C	GLY110
C	ASP111
C	VAL112
C	ASN141
C	PRO143
C	VAL146

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Functional Information from PROSITE/UniProt

site_id	PS01131
Number of Residues	29
Details	RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VYEvGPGpGgITrsiLnadvae..LlVVEkD

Chain	Residue	Details
A	VAL59-ASP87

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31251801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AAX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8JZM0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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