6AAX
Crystal structure of TFB1M and h45 with SAM in homo sapiens
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000154 | biological_process | rRNA modification |
| A | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006391 | biological_process | transcription initiation at mitochondrial promoter |
| A | 0031167 | biological_process | rRNA methylation |
| A | 0034246 | molecular_function | mitochondrial transcription factor activity |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0180026 | biological_process | mitochondrial small ribosomal subunit assembly |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| C | 0000154 | biological_process | rRNA modification |
| C | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006364 | biological_process | rRNA processing |
| C | 0006391 | biological_process | transcription initiation at mitochondrial promoter |
| C | 0031167 | biological_process | rRNA methylation |
| C | 0034246 | molecular_function | mitochondrial transcription factor activity |
| C | 0042645 | cellular_component | mitochondrial nucleoid |
| C | 0180026 | biological_process | mitochondrial small ribosomal subunit assembly |
| C | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue SAM A 401 |
| Chain | Residue |
| A | ASN36 |
| A | GLY110 |
| A | ASP111 |
| A | VAL112 |
| A | ASN141 |
| A | LEU142 |
| A | PRO143 |
| A | VAL146 |
| A | PHE37 |
| A | LEU38 |
| A | GLY63 |
| A | PRO64 |
| A | GLY65 |
| A | GLU85 |
| A | LYS86 |
| A | PHE90 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| A | PRO66 |
| A | ARG71 |
| A | GLY93 |
| C | LEU39 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue SAM C 401 |
| Chain | Residue |
| C | ASN36 |
| C | PHE37 |
| C | LEU38 |
| C | GLY63 |
| C | PRO64 |
| C | PRO66 |
| C | GLY68 |
| C | ILE69 |
| C | GLU85 |
| C | LYS86 |
| C | PHE90 |
| C | GLY110 |
| C | ASP111 |
| C | VAL112 |
| C | ASN141 |
| C | PRO143 |
| C | VAL146 |
Functional Information from PROSITE/UniProt
| site_id | PS01131 |
| Number of Residues | 29 |
| Details | RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VYEvGPGpGgITrsiLnadvae..LlVVEkD |
| Chain | Residue | Details |
| A | VAL59-ASP87 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31251801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AAX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8JZM0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
