6A91
Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001518 | cellular_component | voltage-gated sodium channel complex |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005248 | molecular_function | voltage-gated sodium channel activity |
A | 0005261 | molecular_function | monoatomic cation channel activity |
A | 0005272 | molecular_function | sodium channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0016020 | cellular_component | membrane |
A | 0019228 | biological_process | neuronal action potential |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0034702 | cellular_component | monoatomic ion channel complex |
A | 0035725 | biological_process | sodium ion transmembrane transport |
A | 0055085 | biological_process | transmembrane transport |
A | 0086010 | biological_process | membrane depolarization during action potential |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 7 |
Details | SITE: Interacts with insect Nav channel => ECO:0000269|PubMed:30049784 |
Chain | Residue | Details |
B | ASP21 | |
A | CYS1109-LYS1171 | |
A | LYS1220-ASP1231 | |
A | GLN1280-THR1298 | |
A | LEU1411-ASN1553 | |
B | TYR33 | |
B | ARG41 | |
B | LYS44 | |
B | PHE48 | |
B | SER49 | |
B | ASP56 | |
A | MET908-LYS921 | |
A | VAL965-HIS981 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE141-MET159 |
site_id | SWS_FT_FI3 |
Number of Residues | 289 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PRO160-THR165 | |
A | CYS941-GLU945 | |
A | GLN1002-VAL1047 | |
A | ALA1070-ILE1086 | |
A | ASP1190-GLU1200 | |
A | LEU1250-THR1262 | |
A | GLY1317-THR1338 | |
A | ILE1362-GLY1387 | |
A | ASP219-TYR224 | |
A | MET281-THR360 | |
A | ARG386-HIS392 | |
A | ASP539-ARG549 | |
A | GLN604-GLY605 | |
A | GLY659-ASP686 | |
A | ASP708-PRO719 | |
A | GLU876-ASN888 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | TYR166-ALA186 |
site_id | SWS_FT_FI5 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | TRP201-VAL218 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ALA225-VAL241 |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | LEU261-TYR280 |
site_id | SWS_FT_FI8 |
Number of Residues | 87 |
Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PHE361-LEU385 | |
A | PHE687-TRP707 | |
A | GLY1048-ASP1069 | |
A | PHE1339-ALA1361 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE393-ALA413 |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PHE520-LEU538 |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE550-LYS569 |
site_id | SWS_FT_FI12 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ASN584-VAL603 |
site_id | SWS_FT_FI13 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | LEU606-PHE623 |
site_id | SWS_FT_FI14 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ALA640-ILE658 |
site_id | SWS_FT_FI15 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PHE720-LEU740 |
site_id | SWS_FT_FI16 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PHE858-LEU875 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE889-ILE907 |
site_id | SWS_FT_FI18 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | TRP922-MET940 |
site_id | SWS_FT_FI19 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ALA946-LYS964 |
site_id | SWS_FT_FI20 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE982-VAL1001 |
site_id | SWS_FT_FI21 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | TYR1087-VAL1108 |
site_id | SWS_FT_FI22 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PHE1172-ILE1189 |
site_id | SWS_FT_FI23 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | VAL1201-ILE1219 |
site_id | SWS_FT_FI24 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | PRO1232-MET1249 |
site_id | SWS_FT_FI25 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | LEU1263-PHE1279 |
site_id | SWS_FT_FI26 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | LEU1299-PHE1316 |
site_id | SWS_FT_FI27 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ILE1388-ILE1410 |
site_id | SWS_FT_FI28 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91 |
Chain | Residue | Details |
A | GLU378 | |
A | TRP1063 |
site_id | SWS_FT_FI29 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95 |
Chain | Residue | Details |
A | GLU701 | |
A | GLU704 | |
A | GLY1062 | |
A | GLY1354 | |
A | ASP1356 |
site_id | SWS_FT_FI30 |
Number of Residues | 7 |
Details | SITE: Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784 |
Chain | Residue | Details |
A | ASP539 | |
A | ASP542 | |
A | ARG549 | |
A | ARG613 | |
A | GLN1002 | |
A | ARG1027 | |
A | HIS1032 |
site_id | SWS_FT_FI31 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ASN300 |
site_id | SWS_FT_FI32 |
Number of Residues | 5 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95 |
Chain | Residue | Details |
A | ASN308 | |
A | ASN312 | |
A | ASN330 | |
A | ASN1015 | |
A | ASN1034 |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
Chain | Residue | Details |
A | ASN683 |
site_id | SWS_FT_FI34 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
Chain | Residue | Details |
A | ASN1028 |