6A69
Cryo-EM structure of a P-type ATPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001772 | cellular_component | immunological synapse |
| A | 0001818 | biological_process | negative regulation of cytokine production |
| A | 0003056 | biological_process | regulation of vascular associated smooth muscle contraction |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005388 | molecular_function | P-type calcium transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0008217 | biological_process | regulation of blood pressure |
| A | 0015085 | molecular_function | calcium ion transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030165 | molecular_function | PDZ domain binding |
| A | 0030501 | biological_process | positive regulation of bone mineralization |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0042995 | cellular_component | cell projection |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| A | 0051481 | biological_process | negative regulation of cytosolic calcium ion concentration |
| A | 0051928 | biological_process | positive regulation of calcium ion transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098684 | cellular_component | photoreceptor ribbon synapse |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 1900076 | biological_process | regulation of cellular response to insulin stimulus |
| A | 1903779 | biological_process | regulation of cardiac conduction |
| A | 1990034 | biological_process | calcium ion export across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP475-THR481 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30190470 |
| Chain | Residue | Details |
| B | LEU224-TYR244 | |
| A | SER176-LEU366 | |
| A | THR440-PHE855 | |
| A | THR904-THR927 | |
| A | LYS992-ASN1005 | |
| A | ILE1061-SER1220 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | GLU245-ASN282 | |
| A | GLU155-TRP175 | |
| A | THR367-ILE386 | |
| A | MET928-PHE948 | |
| A | TYR972-ARG991 | |
| A | ASN1006-GLY1027 | |
| A | GLN1040-THR1060 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN55 | |
| B | ASN81 | |
| B | ASN201 | |
| A | ALA949-HIS971 | |
| A | GLY1028-GLU1039 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| B | ASN113 | |
| A | LEU856-ILE876 | |
| A | LYS883-ALA903 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN168 | |
| B | ASN180 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q5ZWR1 |
| Chain | Residue | Details |
| A | ASP475 | |
| A | THR477 | |
| A | ASP797 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylglycine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER8 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER17 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:G5E829 |
| Chain | Residue | Details |
| A | SER338 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:1827443 |
| Chain | Residue | Details |
| A | THR1116 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11505 |
| Chain | Residue | Details |
| A | SER1178 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER1193 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR1203 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER1216 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER1220 |
