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6A4J

Crystal structure of Thioredoxin reductase 2 from Staphylococcus aureus

Replaces:  5ZBV
Functional Information from GO Data
ChainGOidnamespacecontents
A0004324molecular_functionferredoxin-NADP+ reductase activity
A0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
A0016491molecular_functionoxidoreductase activity
A0045454biological_processcell redox homeostasis
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0098869biological_processcellular oxidant detoxification
B0004324molecular_functionferredoxin-NADP+ reductase activity
B0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
B0016491molecular_functionoxidoreductase activity
B0045454biological_processcell redox homeostasis
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue FAD A 401
ChainResidue
AGLY8
ATYR43
AILE48
AASP50
AVAL83
AALA112
AILE113
AGLY114
AGLY116
AILE117
AILE118
AGLY10
AVAL139
APHE245
ALEU251
AGLY284
AASP285
AILE296
BVAL324
BSER325
BSER326
BHIS327
APRO11
ASER12
AASP31
AVAL32
AGLN33
AGLY38
ALYS39

site_idAC2
Number of Residues26
Detailsbinding site for residue FAD B 401
ChainResidue
ASER325
ASER326
BGLY8
BPRO11
BSER12
BASP31
BVAL32
BGLN33
BGLY38
BLYS39
BTYR43
BILE48
BASP50
BVAL83
BALA112
BILE113
BGLY114
BGLY116
BILE117
BILE118
BVAL139
BLEU251
BASP285
BHIS294
BLEU295
BILE296

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01685
ChainResidueDetails
ASER12
BASP31
BLYS39
BTYR43
BVAL83
BILE118
BASP285
BSER326
AASP31
ALYS39
ATYR43
AVAL83
AILE118
AASP285
ASER326
BSER12

227344

PDB entries from 2024-11-13

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