6A2S

Mycobacterium tuberculosis LexA C-domain S160A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009432	biological_process	SOS response
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009432	biological_process	SOS response
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0009432	biological_process	SOS response
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0009432	biological_process	SOS response
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0009432	biological_process	SOS response
E	0045892	biological_process	negative regulation of DNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0009432	biological_process	SOS response
F	0045892	biological_process	negative regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0004252	molecular_function	serine-type endopeptidase activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0009432	biological_process	SOS response
G	0045892	biological_process	negative regulation of DNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0009432	biological_process	SOS response
H	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PEG A 301

Chain	Residue
A	PRO140
A	LEU151
A	PHE152
A	GLN176
A	LEU226
A	HOH421
C	ASN221

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site_id	AC2
Number of Residues	8
Details	binding site for residue PEG A 302

Chain	Residue
A	HOH419
C	VAL179
C	ALA180
C	PHE199
C	GLY220
C	ALA223
A	ASN178
A	VAL179

---

site_id	AC3
Number of Residues	9
Details	binding site for residue P6G A 303

Chain	Residue
A	VAL162
A	GLU163
B	VAL162
B	GLU163
C	VAL162
C	GLU163
C	CME167
D	VAL162
D	GLU163

---

site_id	AC4
Number of Residues	1
Details	binding site for residue PEG B 301

Chain	Residue
B	GLN176

---

site_id	AC5
Number of Residues	1
Details	binding site for residue PEG B 302

Chain	Residue
B	GLN176

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PEG C 301

Chain	Residue
A	ASN221
A	ASP222
C	GLN176
C	LEU226

---

site_id	AC7
Number of Residues	2
Details	binding site for residue P6G C 302

Chain	Residue
C	LYS235
D	LEU151

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PEG D 301

Chain	Residue
D	ASP168
F	GLY220
F	ASN221
F	ALA223

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PEG E 301

Chain	Residue
E	CME167
E	ARG234
F	ALA164
F	ILE166

---

site_id	AD1
Number of Residues	2
Details	binding site for residue PEG F 301

Chain	Residue
F	ARG143
F	GLU144

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: For autocatalytic cleavage activity => ECO:0000255|HAMAP-Rule:MF_00015

Chain	Residue	Details
A	ALA160
E	LYS197
F	ALA160
F	LYS197
G	ALA160
G	LYS197
H	ALA160
H	LYS197
A	LYS197
B	ALA160
B	LYS197
C	ALA160
C	LYS197
D	ALA160
D	LYS197
E	ALA160

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