6A0T
Homoserine dehydrogenase K99A mutant from Thermus thermophilus HB8 complexed with HSE and NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 401 |
| Chain | Residue |
| B | GLU121 |
| B | VAL124 |
| B | ALA126 |
| B | THR128 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue HSE B 402 |
| Chain | Residue |
| B | ASP186 |
| B | ASP191 |
| B | LYS195 |
| B | GLY288 |
| B | NAP403 |
| B | HOH629 |
| B | HOH741 |
| B | ASN150 |
| B | GLY151 |
| B | THR152 |
| B | TYR178 |
| B | GLU180 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | binding site for residue NAP B 403 |
| Chain | Residue |
| B | GLY10 |
| B | GLY11 |
| B | GLY12 |
| B | THR13 |
| B | VAL14 |
| B | LEU42 |
| B | VAL43 |
| B | ARG44 |
| B | ASP45 |
| B | LYS48 |
| B | ARG50 |
| B | ALA73 |
| B | MET74 |
| B | GLY75 |
| B | ALA79 |
| B | ALA97 |
| B | ASN98 |
| B | ALA122 |
| B | GLY177 |
| B | GLU180 |
| B | ALA289 |
| B | GLY290 |
| B | THR294 |
| B | HSE402 |
| B | HOH509 |
| B | HOH513 |
| B | HOH527 |
| B | HOH553 |
| B | HOH567 |
| B | HOH602 |
| B | HOH617 |
| B | HOH629 |
| B | HOH640 |
| B | HOH648 |
| B | HOH699 |
| B | HOH744 |
| B | HOH751 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue CXS B 404 |
| Chain | Residue |
| B | GLU2 |
| B | ALA3 |
| B | PHE305 |
| B | GLY308 |
| B | HOH502 |
| B | HOH612 |
| B | HOH694 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 405 |
| Chain | Residue |
| B | GLY147 |
| B | ILE148 |
| B | LEU149 |
| B | ASN150 |
| B | ALA192 |
| B | LEU238 |
| B | ALA240 |
| B | HOH528 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 406 |
| Chain | Residue |
| B | TRP106 |
| B | ARG110 |
| B | GLY207 |
| B | HOH610 |
| B | HOH626 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 407 |
| Chain | Residue |
| B | ALA105 |
| B | GLU107 |
| B | SER108 |
| B | HOH771 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 408 |
| Chain | Residue |
| B | GLY291 |
| B | GLY292 |
| B | HOH504 |
| B | HOH526 |
| B | HOH594 |
| B | HOH782 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 409 |
| Chain | Residue |
| A | GOL412 |
| B | GLY151 |
| B | TYR178 |
| B | ASN270 |
| B | PRO287 |
| B | GLY288 |
| B | ALA289 |
| B | HOH534 |
| B | HOH659 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 410 |
| Chain | Residue |
| B | HOH778 |
| B | GLU144 |
| B | SER326 |
| B | PRO327 |
| B | TRP328 |
| B | HOH505 |
| B | HOH540 |
| B | HOH686 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | GLU121 |
| A | VAL124 |
| A | MET125 |
| A | ALA126 |
| A | THR128 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue HSE A 402 |
| Chain | Residue |
| A | ASN150 |
| A | GLY151 |
| A | THR152 |
| A | TYR178 |
| A | GLU180 |
| A | ASP186 |
| A | ASP191 |
| A | LYS195 |
| A | GLY288 |
| A | ALA289 |
| A | NAP403 |
| A | HOH583 |
| A | HOH704 |
| site_id | AD4 |
| Number of Residues | 38 |
| Details | binding site for residue NAP A 403 |
| Chain | Residue |
| A | GLY10 |
| A | GLY11 |
| A | GLY12 |
| A | THR13 |
| A | VAL14 |
| A | LEU42 |
| A | VAL43 |
| A | ARG44 |
| A | ASP45 |
| A | ARG50 |
| A | ALA73 |
| A | MET74 |
| A | GLY75 |
| A | ALA97 |
| A | ASN98 |
| A | ALA122 |
| A | GLY177 |
| A | GLU180 |
| A | ALA289 |
| A | GLY290 |
| A | THR294 |
| A | HSE402 |
| A | HOH502 |
| A | HOH526 |
| A | HOH551 |
| A | HOH581 |
| A | HOH592 |
| A | HOH605 |
| A | HOH639 |
| A | HOH643 |
| A | HOH647 |
| A | HOH679 |
| A | HOH707 |
| A | HOH728 |
| A | HOH740 |
| B | LEU171 |
| B | GLN174 |
| B | HOH631 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 404 |
| Chain | Residue |
| A | GLY147 |
| A | ILE148 |
| A | LEU149 |
| A | ASN150 |
| A | ALA192 |
| A | LEU238 |
| A | ALA240 |
| A | HOH544 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 405 |
| Chain | Residue |
| A | GLU141 |
| A | ARG317 |
| A | ARG319 |
| A | HOH685 |
| B | ARG25 |
| B | GLU28 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 406 |
| Chain | Residue |
| A | SER16 |
| A | ARG50 |
| A | ALA51 |
| A | HOH510 |
| A | HOH596 |
| B | ARG50 |
| B | ILE52 |
| B | HOH732 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue FMT A 407 |
| Chain | Residue |
| A | ARG50 |
| A | ILE52 |
| A | PRO53 |
| A | HOH508 |
| A | HOH552 |
| A | HOH594 |
| A | HOH670 |
| A | HOH746 |
| B | ASN20 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 408 |
| Chain | Residue |
| A | VAL77 |
| A | GLU78 |
| A | ALA79 |
| A | HOH569 |
| A | HOH636 |
| B | TYR166 |
| B | LEU170 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 409 |
| Chain | Residue |
| A | LEU81 |
| A | ALA105 |
| A | GLU107 |
| A | SER108 |
| A | HOH541 |
| A | HOH615 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 410 |
| Chain | Residue |
| A | GLY151 |
| A | TYR155 |
| A | TYR178 |
| A | ASN270 |
| A | PRO287 |
| A | GLY288 |
| A | ALA289 |
| A | HOH520 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 411 |
| Chain | Residue |
| A | GLU144 |
| A | SER326 |
| A | PRO327 |
| A | TRP328 |
| A | HOH504 |
| A | HOH512 |
| A | HOH553 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 412 |
| Chain | Residue |
| A | GLU281 |
| A | HOH506 |
| B | ARG268 |
| B | GLY269 |
| B | PRO287 |
| B | GOL409 |
| B | HOH525 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
| Chain | Residue | Details |
| B | ALA173-LYS195 |
