6A0S
Homoserine dehydrogenase from Thermus thermophilus HB8 complexed with HSE and NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 401 |
| Chain | Residue |
| B | GLU121 |
| B | VAL124 |
| B | ALA126 |
| B | THR128 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue HSE B 402 |
| Chain | Residue |
| B | GLU180 |
| B | ASP186 |
| B | ASP191 |
| B | LYS195 |
| B | GLY288 |
| B | NDP403 |
| B | HOH609 |
| B | LYS99 |
| B | ASN150 |
| B | GLY151 |
| B | THR152 |
| B | TYR178 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | binding site for residue NDP B 403 |
| Chain | Residue |
| A | LEU171 |
| A | GLN174 |
| B | GLY10 |
| B | GLY11 |
| B | GLY12 |
| B | THR13 |
| B | VAL14 |
| B | VAL43 |
| B | ARG44 |
| B | ASP45 |
| B | ARG50 |
| B | ALA73 |
| B | MET74 |
| B | GLY75 |
| B | ALA97 |
| B | ASN98 |
| B | LYS99 |
| B | GLY177 |
| B | GLU180 |
| B | ALA289 |
| B | GLY290 |
| B | THR294 |
| B | HSE402 |
| B | HOH508 |
| B | HOH512 |
| B | HOH544 |
| B | HOH546 |
| B | HOH575 |
| B | HOH662 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CXS B 404 |
| Chain | Residue |
| B | PHE305 |
| B | GLY308 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 405 |
| Chain | Residue |
| A | GLU141 |
| A | ARG317 |
| A | ARG319 |
| B | ARG25 |
| B | GLU28 |
| B | HOH526 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 406 |
| Chain | Residue |
| B | ALA103 |
| B | ARG201 |
| B | PRO209 |
| B | PHE210 |
| B | HOH567 |
| B | HOH599 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 407 |
| Chain | Residue |
| B | GLY147 |
| B | LEU149 |
| B | ASN150 |
| B | ALA192 |
| B | LEU238 |
| B | ALA240 |
| B | HOH511 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 408 |
| Chain | Residue |
| B | ALA105 |
| B | GLU107 |
| B | SER108 |
| B | HOH566 |
| B | HOH616 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 409 |
| Chain | Residue |
| A | ARG82 |
| B | THR165 |
| B | TYR166 |
| B | PRO223 |
| B | HOH610 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 410 |
| Chain | Residue |
| B | LEU39 |
| B | ARG58 |
| B | PHE62 |
| B | HOH675 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 411 |
| Chain | Residue |
| A | GLU141 |
| A | HOH577 |
| B | GLU24 |
| B | HOH655 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | GLU121 |
| A | VAL124 |
| A | MET125 |
| A | ALA126 |
| A | THR128 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue HSE A 402 |
| Chain | Residue |
| A | GLY288 |
| A | NDP403 |
| A | HOH584 |
| A | LYS99 |
| A | ASN150 |
| A | GLY151 |
| A | THR152 |
| A | TYR178 |
| A | ALA179 |
| A | GLU180 |
| A | ASP186 |
| A | ASP191 |
| A | LYS195 |
| site_id | AD5 |
| Number of Residues | 30 |
| Details | binding site for residue NDP A 403 |
| Chain | Residue |
| A | GLY10 |
| A | GLY11 |
| A | GLY12 |
| A | THR13 |
| A | VAL14 |
| A | VAL43 |
| A | ARG44 |
| A | ASP45 |
| A | LYS48 |
| A | ARG50 |
| A | ALA73 |
| A | MET74 |
| A | GLY75 |
| A | ALA97 |
| A | ASN98 |
| A | LYS99 |
| A | GLY177 |
| A | GLU180 |
| A | ALA289 |
| A | GLY290 |
| A | THR294 |
| A | HSE402 |
| A | HOH518 |
| A | HOH531 |
| A | HOH562 |
| A | HOH582 |
| A | HOH658 |
| B | LEU170 |
| B | LEU171 |
| B | GLN174 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 404 |
| Chain | Residue |
| A | GLU107 |
| A | ARG110 |
| A | GLY207 |
| A | HOH555 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 405 |
| Chain | Residue |
| A | GLY147 |
| A | LEU149 |
| A | ASN150 |
| A | ALA192 |
| A | LEU238 |
| A | ALA240 |
| A | HOH506 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 406 |
| Chain | Residue |
| A | THR165 |
| A | TYR166 |
| A | PRO223 |
| A | HOH523 |
| B | ARG82 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 407 |
| Chain | Residue |
| A | LEU81 |
| A | ALA105 |
| A | GLU107 |
| A | SER108 |
| A | HOH537 |
| A | HOH639 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 408 |
| Chain | Residue |
| A | SER16 |
| A | ARG50 |
| A | ALA51 |
| A | HOH514 |
| A | HOH524 |
| A | HOH672 |
| B | ARG50 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 409 |
| Chain | Residue |
| A | ARG58 |
| A | ALA59 |
| A | GLU60 |
| A | HOH630 |
| A | HOH702 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 410 |
| Chain | Residue |
| A | ALA3 |
| A | ARG37 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
| Chain | Residue | Details |
| B | ALA173-LYS195 |
