6A0R
Homoserine dehydrogenase from Thermus thermophilus HB8 unliganded form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004412 | molecular_function | homoserine dehydrogenase activity |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004412 | molecular_function | homoserine dehydrogenase activity |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0009088 | biological_process | threonine biosynthetic process |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue NA B 401 |
Chain | Residue |
B | GLU121 |
B | VAL124 |
B | ALA126 |
B | THR128 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue FMT B 402 |
Chain | Residue |
B | ALA192 |
B | LEU238 |
B | ALA240 |
B | HOH501 |
B | GLY147 |
B | ILE148 |
B | LEU149 |
B | ASN150 |
B | THR153 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue FMT B 403 |
Chain | Residue |
A | ILE52 |
A | PRO53 |
A | HOH510 |
B | ASN20 |
B | HOH554 |
B | HOH564 |
B | HOH671 |
B | HOH738 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue FMT B 404 |
Chain | Residue |
A | GLU141 |
A | ARG317 |
A | ARG319 |
B | ARG25 |
B | GLU28 |
B | HOH512 |
B | HOH533 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue FMT B 405 |
Chain | Residue |
B | GLY10 |
B | GLY11 |
B | GLY12 |
B | VAL43 |
B | ARG44 |
B | ARG50 |
B | HOH507 |
B | HOH585 |
B | HOH665 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue FMT B 406 |
Chain | Residue |
B | LEU39 |
B | ARG58 |
B | PHE62 |
B | HOH656 |
B | HOH702 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue FMT B 407 |
Chain | Residue |
B | LEU81 |
B | ALA105 |
B | GLU107 |
B | SER108 |
B | HOH581 |
B | HOH715 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue FMT B 408 |
Chain | Residue |
A | ARG82 |
B | TYR166 |
B | PRO223 |
B | HOH679 |
B | HOH713 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue FMT B 409 |
Chain | Residue |
B | ALA73 |
B | MET74 |
B | ALA97 |
B | ASN98 |
B | LYS99 |
B | HOH516 |
B | HOH519 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue FMT B 410 |
Chain | Residue |
B | TRP106 |
B | GLU107 |
B | ARG110 |
B | GLY207 |
B | HOH530 |
B | HOH602 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue FMT B 411 |
Chain | Residue |
B | ALA103 |
B | ARG201 |
B | PRO209 |
B | PHE210 |
B | HOH530 |
B | HOH531 |
B | HOH577 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue CXS B 412 |
Chain | Residue |
B | GLU2 |
B | VAL34 |
B | PHE305 |
B | LEU306 |
B | SER307 |
B | GLY308 |
B | HOH734 |
B | HOH767 |
site_id | AD4 |
Number of Residues | 12 |
Details | binding site for residue CXS B 413 |
Chain | Residue |
A | GLU281 |
B | GLY151 |
B | TYR178 |
B | ARG268 |
B | GLY269 |
B | ASN270 |
B | PRO287 |
B | GLY288 |
B | ALA289 |
B | HOH660 |
B | HOH714 |
B | HOH807 |
site_id | AD5 |
Number of Residues | 12 |
Details | binding site for residue GOL B 414 |
Chain | Residue |
B | HOH532 |
B | HOH598 |
B | HOH709 |
B | HOH745 |
B | HOH823 |
B | HOH851 |
A | GLY292 |
B | GLU55 |
B | ALA276 |
B | ARG277 |
B | PRO278 |
B | HOH509 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue NA A 401 |
Chain | Residue |
A | GLU121 |
A | VAL124 |
A | ALA126 |
A | THR128 |
site_id | AD7 |
Number of Residues | 8 |
Details | binding site for residue FMT A 402 |
Chain | Residue |
A | GLY147 |
A | ILE148 |
A | LEU149 |
A | ASN150 |
A | ALA192 |
A | LEU238 |
A | ALA240 |
A | HOH528 |
site_id | AD8 |
Number of Residues | 9 |
Details | binding site for residue FMT A 403 |
Chain | Residue |
A | GLY10 |
A | GLY11 |
A | GLY12 |
A | LEU42 |
A | VAL43 |
A | ARG44 |
A | HOH525 |
A | HOH588 |
A | HOH737 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue FMT A 404 |
Chain | Residue |
A | TYR166 |
A | PRO223 |
A | HOH629 |
B | ARG82 |
site_id | AE1 |
Number of Residues | 7 |
Details | binding site for residue FMT A 405 |
Chain | Residue |
A | SER16 |
A | ARG50 |
A | ALA51 |
A | HOH555 |
B | ARG50 |
B | ILE52 |
B | HOH728 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue FMT A 406 |
Chain | Residue |
A | ARG110 |
A | GLY207 |
A | HOH563 |
A | HOH565 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue FMT A 407 |
Chain | Residue |
A | ALA3 |
A | ARG37 |
A | HOH570 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue FMT A 408 |
Chain | Residue |
A | LEU81 |
A | ALA105 |
A | GLU107 |
A | SER108 |
A | HOH667 |
A | HOH677 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 409 |
Chain | Residue |
A | PRO46 |
A | LEU57 |
A | ARG58 |
A | ALA59 |
A | GLU60 |
A | HOH532 |
Functional Information from PROSITE/UniProt
site_id | PS01042 |
Number of Residues | 23 |
Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
Chain | Residue | Details |
B | ALA173-LYS195 |