6A0R
Homoserine dehydrogenase from Thermus thermophilus HB8 unliganded form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 401 |
| Chain | Residue |
| B | GLU121 |
| B | VAL124 |
| B | ALA126 |
| B | THR128 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue FMT B 402 |
| Chain | Residue |
| B | ALA192 |
| B | LEU238 |
| B | ALA240 |
| B | HOH501 |
| B | GLY147 |
| B | ILE148 |
| B | LEU149 |
| B | ASN150 |
| B | THR153 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 403 |
| Chain | Residue |
| A | ILE52 |
| A | PRO53 |
| A | HOH510 |
| B | ASN20 |
| B | HOH554 |
| B | HOH564 |
| B | HOH671 |
| B | HOH738 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 404 |
| Chain | Residue |
| A | GLU141 |
| A | ARG317 |
| A | ARG319 |
| B | ARG25 |
| B | GLU28 |
| B | HOH512 |
| B | HOH533 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue FMT B 405 |
| Chain | Residue |
| B | GLY10 |
| B | GLY11 |
| B | GLY12 |
| B | VAL43 |
| B | ARG44 |
| B | ARG50 |
| B | HOH507 |
| B | HOH585 |
| B | HOH665 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 406 |
| Chain | Residue |
| B | LEU39 |
| B | ARG58 |
| B | PHE62 |
| B | HOH656 |
| B | HOH702 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 407 |
| Chain | Residue |
| B | LEU81 |
| B | ALA105 |
| B | GLU107 |
| B | SER108 |
| B | HOH581 |
| B | HOH715 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 408 |
| Chain | Residue |
| A | ARG82 |
| B | TYR166 |
| B | PRO223 |
| B | HOH679 |
| B | HOH713 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 409 |
| Chain | Residue |
| B | ALA73 |
| B | MET74 |
| B | ALA97 |
| B | ASN98 |
| B | LYS99 |
| B | HOH516 |
| B | HOH519 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 410 |
| Chain | Residue |
| B | TRP106 |
| B | GLU107 |
| B | ARG110 |
| B | GLY207 |
| B | HOH530 |
| B | HOH602 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 411 |
| Chain | Residue |
| B | ALA103 |
| B | ARG201 |
| B | PRO209 |
| B | PHE210 |
| B | HOH530 |
| B | HOH531 |
| B | HOH577 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue CXS B 412 |
| Chain | Residue |
| B | GLU2 |
| B | VAL34 |
| B | PHE305 |
| B | LEU306 |
| B | SER307 |
| B | GLY308 |
| B | HOH734 |
| B | HOH767 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue CXS B 413 |
| Chain | Residue |
| A | GLU281 |
| B | GLY151 |
| B | TYR178 |
| B | ARG268 |
| B | GLY269 |
| B | ASN270 |
| B | PRO287 |
| B | GLY288 |
| B | ALA289 |
| B | HOH660 |
| B | HOH714 |
| B | HOH807 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue GOL B 414 |
| Chain | Residue |
| B | HOH532 |
| B | HOH598 |
| B | HOH709 |
| B | HOH745 |
| B | HOH823 |
| B | HOH851 |
| A | GLY292 |
| B | GLU55 |
| B | ALA276 |
| B | ARG277 |
| B | PRO278 |
| B | HOH509 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | GLU121 |
| A | VAL124 |
| A | ALA126 |
| A | THR128 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 402 |
| Chain | Residue |
| A | GLY147 |
| A | ILE148 |
| A | LEU149 |
| A | ASN150 |
| A | ALA192 |
| A | LEU238 |
| A | ALA240 |
| A | HOH528 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue FMT A 403 |
| Chain | Residue |
| A | GLY10 |
| A | GLY11 |
| A | GLY12 |
| A | LEU42 |
| A | VAL43 |
| A | ARG44 |
| A | HOH525 |
| A | HOH588 |
| A | HOH737 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 404 |
| Chain | Residue |
| A | TYR166 |
| A | PRO223 |
| A | HOH629 |
| B | ARG82 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 405 |
| Chain | Residue |
| A | SER16 |
| A | ARG50 |
| A | ALA51 |
| A | HOH555 |
| B | ARG50 |
| B | ILE52 |
| B | HOH728 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 406 |
| Chain | Residue |
| A | ARG110 |
| A | GLY207 |
| A | HOH563 |
| A | HOH565 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 407 |
| Chain | Residue |
| A | ALA3 |
| A | ARG37 |
| A | HOH570 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 408 |
| Chain | Residue |
| A | LEU81 |
| A | ALA105 |
| A | GLU107 |
| A | SER108 |
| A | HOH667 |
| A | HOH677 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 409 |
| Chain | Residue |
| A | PRO46 |
| A | LEU57 |
| A | ARG58 |
| A | ALA59 |
| A | GLU60 |
| A | HOH532 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
| Chain | Residue | Details |
| B | ALA173-LYS195 |
