5ZY6
catechol methyltransferase spCOMT
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006584 | biological_process | catecholamine metabolic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008171 | molecular_function | O-methyltransferase activity |
A | 0010340 | molecular_function | carboxyl-O-methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0046872 | molecular_function | metal ion binding |
A | 1990748 | biological_process | cellular detoxification |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006584 | biological_process | catecholamine metabolic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0008171 | molecular_function | O-methyltransferase activity |
B | 0010340 | molecular_function | carboxyl-O-methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0046872 | molecular_function | metal ion binding |
B | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue SAM A 301 |
Chain | Residue |
A | MET54 |
A | VAL107 |
A | TYR111 |
A | ALA135 |
A | ASP162 |
A | HIS163 |
A | TRP164 |
A | LEU167 |
A | HOH417 |
A | HOH456 |
A | ILE56 |
A | GLY80 |
A | GLY81 |
A | TYR82 |
A | TYR85 |
A | SER86 |
A | LEU105 |
A | GLU106 |
site_id | AC2 |
Number of Residues | 19 |
Details | binding site for residue SAM B 301 |
Chain | Residue |
B | MET54 |
B | ILE56 |
B | GLY80 |
B | GLY81 |
B | TYR82 |
B | TYR85 |
B | SER86 |
B | LEU105 |
B | GLU106 |
B | VAL107 |
B | TYR111 |
B | ALA135 |
B | ASP162 |
B | HIS163 |
B | TRP164 |
B | LEU167 |
B | HOH457 |
B | HOH486 |
B | HOH513 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 |
Chain | Residue | Details |
A | ILE56 | |
B | SER86 | |
B | GLU106 | |
B | VAL107 | |
B | ALA135 | |
B | ASP162 | |
A | GLU78 | |
A | SER86 | |
A | GLU106 | |
A | VAL107 | |
A | ALA135 | |
A | ASP162 | |
B | ILE56 | |
B | GLU78 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LYS165 | |
A | ASP190 | |
A | ASN191 | |
B | LYS165 | |
B | ASP190 | |
B | ASN191 |