5ZY6
catechol methyltransferase spCOMT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0010340 | molecular_function | carboxyl-O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990748 | biological_process | cellular detoxification |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0010340 | molecular_function | carboxyl-O-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue SAM A 301 |
| Chain | Residue |
| A | MET54 |
| A | VAL107 |
| A | TYR111 |
| A | ALA135 |
| A | ASP162 |
| A | HIS163 |
| A | TRP164 |
| A | LEU167 |
| A | HOH417 |
| A | HOH456 |
| A | ILE56 |
| A | GLY80 |
| A | GLY81 |
| A | TYR82 |
| A | TYR85 |
| A | SER86 |
| A | LEU105 |
| A | GLU106 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue SAM B 301 |
| Chain | Residue |
| B | MET54 |
| B | ILE56 |
| B | GLY80 |
| B | GLY81 |
| B | TYR82 |
| B | TYR85 |
| B | SER86 |
| B | LEU105 |
| B | GLU106 |
| B | VAL107 |
| B | TYR111 |
| B | ALA135 |
| B | ASP162 |
| B | HIS163 |
| B | TRP164 |
| B | LEU167 |
| B | HOH457 |
| B | HOH486 |
| B | HOH513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
